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All Journal Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication Jurnal Media Gizi Indonesia (MGI) Molecular and Cellular Biomedical Sciences (MCBS) AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Health Sains Jurnal Ilmu Faal Olahraga Indonesia
Gaga Irawan Nugraha
Fakultas Kedokteran Universitas Padjadjaran
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Molecular and Cellular Biomedical Sciences (MCBS)

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Antioxidant Effects of Red Fruit Oil on MMP-1 Gene Expression and Malondialdehyde Levels on Skin Exposed to UVB Rays Monita Sugianto; Achadiyani Achadiyani; Gaga Irawan Nugraha
Molecular and Cellular Biomedical Sciences Vol 3, No 2 (2019)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v3i2.68

Abstract

Background: Chronic exposure ultraviolet (UV)-B radiation causes reactive oxygen species (ROS) formation. Furthermore, ROS will induce the formation of malondialdehyde and increase matrix metalloproteinase (MMP)-1 expression. One strategy against the free radicals effects is by consuming antioxidants. This study aims to analyze the antioxidants effect of red fruit oil (RFO) on MMP-1 expression and malondialdehyde levels due to exposure to UVB rays.Materials and Methods: Thirty male Wistar rats were divided into 5 groups. The P0 group was not given treatment, the P1 group was only exposed to UVB light, the P2 group was exposed to UVB light and given 0.5 mL/200 g body weight (BW) of RFO, the P3 group was exposed to UVB light and given 1 mL/200 g BW of RFO, and group P4 exposed to UVB rays and given 2 mL/200 g BW of RFO. Experimental animals would be examined for MMP-1 expression and malondialdehyde level. RFO would be identified with β-carotene and tocopherol content.Results: Beta-carotene and tocopherol were detected in RFO. RFO reduced significantly MMP-1 expression (p<0.05) in P2 group (0.73±1.27), P3 group (0.63±0.95), P4 group (9.56±20.97) compared group P1 (48.07±65.58). However, RFO did not reduce malondialdehyde levels (p>0.05).Conclusion: Our research demonstrates RFO containing tocopherol and β-carotene can reduce the MMP-1 expression, but does not affect malondialdehyde levels due to exposure to UVB rays. An effective dose that can reduce malondialdehyde levels and MMP-1 expression is 1 mL/200 g BW.Keywords: red fruit oil, antioxidant, skin, MMP-1 expression, malondialdehyde, UVB rays, photoaging 
Co-Authors - Yusnita, - Achadiyani Ambrosius Purba Ambrosius Purba Armijn Firman Armijn Firman, Armijn Bellia Loranthifolia Martasari Budi Setiabudiawan Cafrina, Gabriella Cahyadi, Wisnu Dany Hilmanto Dewi, Ni Wayan Eka Rahayu Dida Akhmad Gurnida Dida Akhmad Gurnida Dwi Agustian Elissa Evanti Widjaja Farid Husin Farid Husin Firman Fuad Wirakusumah Gabriella Cafrina Gloria Kartika Gurid PE Mulyo Henni Djuhaeni Hikmat Permana Hikmat Permana I Made Jawi Irma Ruslina Defi Kartika, Gloria Kasmanto, Hendro Kavita Arumugam Kavita Arumugam, Kavita Kusnandi Rusmil Kusnandi Rusmil Lasiyati Yuswo Yani Lisda Amalia Lola Ilona Lukman Pura Lynna Lidyana Lynna Lidyana Mieke Hemiawati Satari Monita Sugianto Oki Suwarsa Rachmat Soelaeman Rezah Andriani Ria Bandiara Rudi Supriyadi Sefti Atletika Asiani Sefti Atletika Asiani Seni Rahayu Setiawan Setiawan Siti Nur Fatimah Siti Nur Fatimah Sri Hartini K. S. Kariadi Stephanus Kristianto Witono Sudigdo Adi Sunarjati Sudidgo Adi Sunarjati Sudigdoadi Sunarjati Sudigdoadi Sunarjati Sudigdoadi Susiarno, Hadi Tiara Aulia Maisyarah Tiara Aulia Maisyarah Titing Nurhayati Vita Murniati Tarawan Vitriana Vitriana Yenni Zuhairini Yesi Herawati Yudi Mulyana Hidayat Zulmansyah , Zulmansyah