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Suspension Stability and Characterization of Chitosan Nanoparticle–Coated Ketoprofen Based on Surfactants Oleic Acid and Poloxamer 188 Nur Qadri Rasyid; Purwantiningsih Sugita; Laksmi Ambarsari; Gustini Syahbirin
Makara Journal of Science Vol 18, No 3 (2014): September
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

In this research, ketoprofen was used as a drug model in the preparation of chitosan nanoparticles as a potential drug delivery system through the ionic gelation process with tripolyphosphate (TPP). The particle size analysis (PSA) revealed that the average particle size, polydispersity index (PI), and entrapment efficiency of chitosan nanoparticles prepared with oleic acid were 253.7 nm and 0.375 with drug entrapment efficiency of 73.30%. Those prepared with poloxamer 188 were 242.94 nm and 0.302 with drug entrapment efficiency of 87.89%. Scanning electron microscopy (SEM) analysis showed that the shapes of the nanoparticles, both prepared with oleic acid and poloxamer 188, were intact and spherical. Fourier transform infrared spectroscopy (FTIR) indicated several differences between the spectra of chitosan- and ketoprofen-loaded chitosan nanoparticles; for example, a new peak at the wavenumber 1409/cm indicated the presence of electrostatic interaction between the carboxyl group of ketoprofen and the amino group of chitosan. The chitosan nanoparticle suspension prepared with poloxamer 188 showed smaller increases in turbidity and viscosity than that prepared with oleic acid after 34 d of storage.
In Silico Screening Anticancer of Six Triterpenoids toward miR-494 and TNF-α Targets Zaini, Vikra Ardiansyah; Sugita, Purwantiningsih; Irfana, Luthfan; Achmadi, Suminar Setiati
Jurnal Kimia Sains dan Aplikasi Vol 23, No 4 (2020): Volume 23 Issue 4 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3049.44 KB) | DOI: 10.14710/jksa.23.4.117-123

Abstract

Hepatocellular carcinoma (HCC) accounts for up to 90% of all primary liver cancers worldwide. Cinobufagin is recognized to inhibit miR-494 as the HCC target. Increased expression of TNF-α results in an inadequate response to liver anticancer drugs. The models in this study were cinobufagin, cycloartenol, and ethyl acetate fractions of Ganoderma lucidum, 2–5. Seven docking targets in this study were Akt, ERK1, ERK2, PI3K, TNF-α, TNFR1, and TNFR2. Cycloartenol and compound 4 comply with Veber’s rules, Lipinski’s rule of 5, and demonstrate moderate toxicity. The action implies a potential docking target since it produces bond affinities with the compound 2–5 that agree with the IC50 in the literature, which is based on in vitro experiments. Akt as a receptor target is AZD5363. Cycloartenol shows a low ability to inhibit Akt. Conversely, compound 4 inhibits the Akt better than that of cycloartenol, although it is not as good as cinobufagin and AZD5363. Therefore, compound 4, a triterpenoid with a basic framework of lanostane has the potential to be an anticancer candidate for the liver.
Komposit Polianilina/Kitosan/Perak Nanowires Sebagai Elektrokatalis Reaksi Evolusi Hidrogen dalam Medium Netral Fakhrullah, Fadli; Sugita, Purwantiningsih; Khotib, Mohammad; Akiyoshi, Takeno; Takahashi, Shinya
ALCHEMY Jurnal Penelitian Kimia Vol 15, No 2 (2019): Vol 15, No 2 (2019) Alchemy Jurnal Penelitian Kimia
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (380.355 KB) | DOI: 10.20961/alchemy.15.2.30460.190-202

Abstract

Studi mengenai elektrokatalis untuk reaksi evolusi hidrogen (HER) dan evolusi oksigen (OER) sangat diperlukan terkait aplikasinya dalam pengembangan energi terbarukan berbasis hidrogen. Komposit perak nanowires (AgNWs) dengan polianilina (PANI) disiapkan dengan metode polimerisasi radikal dalam larutan matriks kitosan untuk menurunkan ukuran partikel PANI. Komposit disintesis dengan 3 perlakuan yang berbeda, yaitu perlakuan suhu ruang, suhu rendah, dan sonikasi. Aktivitas elektrokatalisis diukur dengan voltammetri sapuan linear (LSV). Informasi tentang densitas arus pertukaran dan overpotensial sebagai variabel utama pengukuran aktivitas elektrokatalisis diperoleh dari plot Tafel pada LSV. Semua komposit dengan perlakuan suhu dan sonikasi menunjukkan karakter katodik berdasarkan nilai overpotensialnya yang negatif (aktivitas HER), sedangkan komposit dengan perlakuan suhu rendah memiliki karakter anodik (aktivitas OER).A Composite of   Polyaniline/Chitosan/Silver Nanowires as Hydrogen Evolution Electrocatalyst in Neutral Medium. Study on electrocatalyst for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is urgently needed related to its application in hydrogen-based renewable energy development. A composite of silver nanowires (AgNWs) with polyaniline (PANI) was prepared by radical polymerization method in chitosan matrix solution to reduce the PANI particle size. Each composite was synthesized under three different treatment conditions, which are room temperature, low temperature, and sonication. Linear sweeping voltammetry (LSV) was conducted to measure electrocatalytic activity of the composites. Information about exchange current density and overpotential as important variables in this field were obtained from Tafel plot in the LSV. The temperature and sonication-treated composites have cathodic character due to its negative overpotential (HER activity), while low temperature-treated composites have anodic character (OER activity).
Synthesis and Application of Jatropha Oil based Polyurethane as Paint Coating Material Harjono .; Purwantiningsih Sugita; Zainal Alim Mas’ud
Makara Journal of Science Vol 16, No 2 (2012): Agustus
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

Recently, the use of renewable sources in the preparation of various industrial materials has been revitalized in response to environmental concerns. Natural oils are considered to be the most important genre of renewable sources. Jatropha curcas oil (JPO) based polyol is an alternative material that may possibly replace petrochemical-based polyol for polyurethane coating material. Polyurethane was synthesized by reacting JPO-based polyol with isocyanate. To produce JPO-based polyol, JPO was first epoxidized to form epoxidized J. curcas oil (EJP), subsequently it was converted to polyol by the opening ring reaction with acrylic acid (AA) using triethylamine (TEA) as a catalyst. The JPO-based polyurethane film resulting from this study is compared with polyurethane film from commercial polyol for gloss, hardness, and adhesion quality. The result showed that the source of polyol has an influence on gloss, hardness, and adhesion of polyurethane film, but the differences with using isocyanate has less influence. Using visual observation, polyurethane film produced from L.OHV polyol, H.OHV polyol and commercial polyol have similar qualities.Keywords: coating material, JPO-based polyol, polyurethane
Perilaku Disolusi Ketoprofen Tersalut Gel Kitosan-Karboksimetilselulosa (CMC) Sugita, Purwantiningsih; Achmadi, Suminar Setiati; Yundhana, Yuyu
Jurnal Natur Indonesia Vol 13, No 1 (2010)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.958 KB) | DOI: 10.31258/jnat.13.1.21-26

Abstract

Study dissolution behaviour of ketoprofen through optimum chitosan-CMC microcapsule has been carried out. Into228.6 ml of 1.0% (w/v) chitosan solution in 1% (v/v) acetic acid, 38.1 ml of CMC solution was added with concentrationvariation of 0.075; 0.0875; and 0.10% (w/v). Afterwards, 7.62 mL of glu was added slowly under stirring, withconcentrations varied: 3; 4.5; and 6% (v/v). All mixtures were shaked for 20 minutes for homogenization. Into eachmicrocapsule mixture for ketoprofen, a solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added. Everymixture was then added with 5 ml of 2% Tween-80 and stirred with magnetic stirrer for an hour at room temperature.Conversion of suspension into fine powders/granules (microcapsules) was done by using spray dryer. Thedissolution behaviour of optimum ketoprofen microcapsules were investigated in gastric and intestinal medium.Microcapsule morphology before and after dissolution as well as empty microcapsule (blank) were observed withSEM. Spray drying process had successfully coated ketoprofen in chitosan-CMC microcapsule. Optimization byusing Minitab Release 14 software showed that among the microcapsule compositions studied, CMC and glu of0.0925% (w/v) and 3.01% (v/v), respectively, optimum to coat ketoprofen at constant chitosan concentration 1.0%(w/v). Result of SEM morphology and In vitro dissolution profile showed that ketoprofen in chitosan-CMCmicrocapsule was relatively well than chitosan-guar gum microcapsule. Kinetically, dissolution of ketoprofen frommicrocapsule in intestinal pH condition was first order with release rate constant, k, of 7.285 ï‚´ 10-4 % min-1 andrelease half-time, t1/2, of approximately 15 hours.
Adsorption of Waste Metal Cr(VI) with Composite Membranes (Chitosan-Silica Rice Husks) Fifia Zulti; Kiagus Dahlan; Purwantiningsih Sugita
Makara Journal of Science Vol 16, No 3 (2012): Desember
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

Chromium compounds are widely used in modern industry. Many of these compounds are dumped into the surrounding environment. Membrane technology is more efficient and effective than conventional methods for waste treatment. The research objective is to make a membrane separation process that can be applied to Cr(VI). Membranes are made from chitosan and silica rice husks. Variations of chitosan and silica rice husk used (g) are 2:1 (A1), 2:2 (A2), 3:1 (B1), and 3:2 (B2). The membrane is made by using an inverted phase technique. Results of SEM characterization of membranes show that B2 has the largest pores at 2.58 mm. The FTIR characterization results indicate the presence of crosslinking between chitosan with silica rice husk with the appearance of Si-O adsorption band at wavelength 1122-980/cm. A1 membrane, with the smallest pore size has the greatest rejection value towards Cr(VI) which is 70%. Research shows that the composite membrane of silica rice husk is effective enough to adsorb metal Cr(VI) with an average adsorption capacity of 1665.85 mg/g. Keywords: chitosan, Cr(VI), membrane, silica rice husk
ENKAPSULASI KETOPROFEN DENGAN KITOSAN-ALGINAT BERDASARKAN JENIS DAN RAGAM KONSENTRASI TWEEN 80 DAN SPAN 80 Purwantiningsih Purwantiningsih; Napthaleni ,; Mersi Kurniati; Tuti Wukirsari
Makara Journal of Science Vol 14, No 2 (2010): November
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

Encapsulated Ketoprofen by Chitosan-Alginat based on Type and Variation of Tween 80 and Span 80 Concentration. Ketoprofen has been encapsulated by chitosan-alginate based on types of surfactant and it’s concentration. The variations of concentration either Tween 80 (polietilena sorbitanmonooleat) or Span 80 (sorbitanmonooleat) that used were around (1- 3)% concentrations with stirring around (15-60) minutes. The using of Tween 80 resulted efficiency of encapsulated ketoprofen and nano particle size (100-1000) nm are higher than Span 80.Keywords: encapsulated ketoprofen, chitosan-alginate, Span 80, Tween 80
DISOLUSI MIKROENKAPSULASI KURKUMIN TERSALUT GEL KITOSAN-ALGINAT-GLUTARALDEHIDA Herdini .; Latifah K. Darusman; Purwantiningsih Sugita
Makara Journal of Science Vol 14, No 1 (2010): April
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

Dissolution of Curcumin Microencapsulation Coated by Chitosan-Alginate-Glutaraldehide. In vitro dissolution of curcumin coated by chitosan-alginate gel in its optimum condition was studied. The maceration process using 17.08% ethanol yields and the content of the curcumin in the extract detected by visible spectrophotometry λ 430 nm is found to be 10.30 %. Its optimum condition was obtained using response surface method at concentrations ratio of alginate 0.62% (b/v) and glutaraldehide 4.63% (v/v) , respectively, where the chitosan concentration was fixed (1.75% [b/v]). The dissolution assay was done at 37 oC, at 100 rpm of stirring rate in 8 hours. Aliquots were taken at 15, 30, 45, 60, 90, 120, 150, 180, 240, 300, 360, 420, 480 minutes. Absorbance of the Aliquots was measured at λ 430 nm. The curcumin released has the best linear correlation to the first order reaction with released constant, k = 2.24 10-3 minute-1 while it’s half live is t1/2 = 5.16 hours. Release curcumin was determined mainly by diffusion mechanism. Compared to the result based on Fick model, the one of Higuchi model is better in agreement in reproducing the released data. Keywords: chitosan-alginate-glutaraldehide, curcumin, diffusion-dissolution, microencapsulation
PENGARUH IRADIASI GAMMA TERHADAP DEGRADASI ZAT WARNA DIRECT ORANGE 34 DALAM AIR Sugita, Purwantiningsih; Winarno, Ermin Katrin; Anriani, Lia
Jurnal Teknologi Lingkungan Vol. 1 No. 2 (2000): JURNAL TEKNOLOGI LINGKUNGAN
Publisher : Center for Environmental Technology - Agency for Assessment and Application of Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.851 KB) | DOI: 10.29122/jtl.v1i2.170

Abstract

The aim of this experiment is study on technique of gamma irradiaton in analyzing dying agent direct orange 34 in waste water. Direct orange 34 was dispersed to oxalic and malic acids when the 60Co irradiated. The result showed that dose and dose rate of 60Co were less than 10 kGy and 7.57 kGy/hour, respectively. While, the pH of the first solution was 7.0. The technique showed that the chemical oxygen demand of dye solution was decreased from 60.38 to 4.90 ppm.
Characterization and Bioactive Compound Analysis of Meretrix meretrix Linnaeus Apriandi, Azwin; Tarman, Kustiariyah; Sugita, Purwantiningsih
Marinade Vol 1 No 01 (2018): Marinade
Publisher : Fisheries Product Technology Department, Faculty of Marine Science and Fisheries, Universitas Maritim Raja Ali Haji

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3345/marinade.v1i01.784

Abstract

Meretrix meretrix was one of gastropods seawater has been used by people as a food. These shells are still categorized of bycatch and have not explored the benefits. This study aimed to characterize and analyze the content of bioactive Meretrix meretrix. This research was conducted morphological characterization shellfish sensory, measurement of yield, the content of the proximate analysis, heavy metals, and analysis of bioactive compounds from the extracts of water and methanol. Observation found that the Meretrix meretrix has a yellowish white color with black bars at the end of the shell and the white meat and chewy with a yield of meat and shells of 11.09% and 69.85%. Analysis of water content, ash, fat, protein, and carbohydrates respectively by 79.99%, 1.50%, 0.22%, 9.42% and 8.81%. Heavy metal obtained  8x10-4 ppm Hg content, 13x10-4 ppm Pb, Cd, and Cu 45x10-4 and 88x10-4 ppm. Bioactive compounds in water and methanol extract of shellfish Lamis including alkaloids, steroids, and saponins.