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All Journal Tropical Medicine Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Jurnal Teknosains Program Kreativitas Mahasiswa - Penelitian Indonesian Journal of Biotechnology Majalah Obat Tradisional Indonesian Journal of Chemistry Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Molluca Journal of Chemistry Education (MJoCE) Indonesian Journal of Pharmacology and Therapy Occupational and Environmental Medicine Journal of Indonesia
Eti Nurwening Sholikhah
Departement Of Pharmacology And Therapy, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Majalah Obat Tradisional

 1 
Effects of Poly-herbal Tablet as Herbal Medicine on Lipid Level Woro Rukmi Pratiwi; Eti Nurwening Sholikhah; Dwi Aris Agung Nugrahaningsih; Mia Munawaroh Yuniyanti; Mustofa Mustofa; Ngatidjan Ngatidjan
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.299 KB) | DOI: 10.22146/mot.43108

Abstract

Dyslipidemia is one of the high-risk factors that cause cardiovascular disease and the prevalence is increasing all the time. Garlic (Alii sativi) has been suggested to reduce serum lipid level. Poly-herbal is herbal medicine that has been widely used in Indonesia, and it contains Alii sativi, Belericae fructus, Curcumae aeroginosae, and Amomi fructus extract. This study aimed to evaluate the effects of poly-herbal tablet on lipid levels in dylipidemia subjects. The study was conducted for 6 weeks on 58 dyslipidemic subjects. The subject was divided into 2 groups. Group 1 was given Poly-herbal with the dose 2x1200 mg, and group 2 was not given anti-dyslipidemic drugs (control group). Serum lipid level (total cholesterol, LDL, HDL, and triglycerides) were checked before the treatment (H0) and after the treatment (M6). There was a significant difference on the reduction of serum lipids level between the group that given Poly-herbal vs control group, respectively total cholesterol (-12.04±3.2 vs 8.38±4.3; p=.000),  LDL (-4.42±2.8 vs 6.93±4.7; p=.049) and HDL (-2.62+1.0 vs 3.31+1.4; p=.005). Triglyceride level on Poly-herbal group is not significantly decreased. In Poly-herbal group there was also a decrease in HDL levels which was not statistically significant (-2.62±1, p=.015). This is probably due to the HDL baseline in the control group included in the normal HDL category (57.38 ± 14.9) so that the HDL levels after being given treatment did not increase. This study suggests that using Poly-herbal in dyslipidemia subjects can reduce the level of total cholesterol and LDL.
Effects of Polyherbal Tablet for Hypertensive Patients Woro Rukmi Pratiwi; Eti Nurwening Sholikhah; Dwi Aris Agung Nugrahaningsih; Mia Munawaroh Yuniyanti; Mustofa Mustofa; Setyo Purwono
Majalah Obat Tradisional Vol 25, No 3 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.62363

Abstract

Hypertension is a degenerative disease whose prevalence is high and continues to increase over time. Polyherbal tablet have long been used by Indonesian people for hypertension drugs containing garlic (Alium sativum), jelawe (Belericae fructus), temu ireng rhizomes (Curcumae aeruginosae) and kapulaga (Amomi fructus) extracts. This study aims to determine the effect of polyherbal tablet on hypertensive patients. The subjects of 29 hypertensive patients participated in a open-randomized-without comparison-study for 6 weeks. Subjects were divided into 3 groups, each subject received polyherbal tablet with a dose of 2x600 mg (group 1), 2x1200 mg (group 2) and 2x2400 mg (group 3). Blood pressure was monitored on D-0, D-3, D-5, D-7, W-2, W-3, W-4, W-5 and W-6. There was a significant decrease in systolic and diastolic blood pressure at the sixth week in all three treatment groups. The highest decrease in systolic blood pressure was in group 1 while diastolic blood pressure was in group 2 (-22.94 ± 5.871 and 13.13 ± 4.324 respectively). The lowest reduction in systolic and diastolic blood pressure occurred in the third group (-15.07 ± 3,519 and 8.98 ± 3,394 respectively). This study suggests that polyherbal tablet contains garlic (Alii sativi), jelawe (Belericae Fructus), temu ireng rhizome (Curcumae aeruginosae) and cardamom (Amomi Fructus) can reduce blood pressure in patients with hypertension. 
Co-Authors . Mustofa . Mustofa Achmad Djunaidi Achmad Djunaidi Adisty Ridha Damasuri Aditya Nugraha Anak Agung Ayu Niti Wedayani Anak Agung Ngurah Nata Baskara Andi Hairil Alimuddin Bayu Putra Chairil Anwar Chairil Anwar Danang Setia Budi Demianus Tafor Demianus Tafor Dian Permata Sari Dwi Utami Ema Damayanti Erna Kristin Erwin Astha Triyono Faris Hermawan Faris Hermawan Gandes Retno Rahayu Harno Dwi Pranowo Harno Dwi Pranowo Hera Nirwati Iin Narwanti Ikhsan Nur Salim Iqmal Tahir JAKA WIDADA Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Jumina Laela Hayu Nurani Mae Sri Hartati Wahyuningsih Mahardika Agus Widjayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Mahardika Agus Wijayanti Masriani . Maulina Diah Maya Dian Rakhmawatie Mega Pandu Arfiyanti Muhammad Idham Darussalam Mardjan Muhammad Kusumawan Herliansyah Mujur Mujur Mustafa Mustafa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Muthia Rahayu Iresha Muthia Rahayu Iresha Nendrowati Nendrowati Ngatidjan Ngatidjan Nugrahaningsih, Dwi Aris Agung Pramana Pananja Putra Prasetyo, Yacobus Christian Priska Ernestina Tenda Ratna Sari Rul Afiyah Syarif Ruslin Hadanu Sabirin Mastjeh Sabirin Mastjeh Sabirin Mastjeh Sabirin Mastjeh Sabirin Matsjeh Sabirin Matsjeh Samekto Wibowo Setyo Purwono Sitarina Widyarini Susi Iravati Wahyu Nitari Wahyu Widyaningsih Widya Wasityastuti Winarto Haryadi Woro Rukmi Pratiwi Woro Rukmi Pratiwi Yuniyanti, Mia Munawaroh Zulfa Faiqoh