Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Indonesia Journal Physical Medicine and Rehabilitation

Moderate Intensity Physical Exercise Decreases Gastrocnemius Caspase-3 Expression on Mus musculus with Statin Treatment Junita Jeanne Paliman; Ratna Darjanti Haryadi; Rwahita Satyawati Darmanta; Willy Sandhika; Martha Kurnia Kusumawardani
Indonesian Journal of Physical Medicine & Rehabilitation Vol 10 No 01 (2021): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1685.19 KB) | DOI: 10.36803/ijpmr.v10i1.281

Abstract

ABSTRACTIntroduction: Dyslipidemia is a lipid metabolism abnormality marked by increase or decrease of lipid fraction in the plasma. Statin or 3-Hydroxy-3-Methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor is an important dyslipidemia medication that may induce apoptosis of the skeletal muscle.Decrease of Bcl-2 and Bax ratio causing caspase-9 activation followed by caspase-3 activation occur in apoptosis. Moderate intensity physical exercise (MIPE) decreases DNA fragmentation, increases Bcl-2 protein level and decreases Bax transcript level.Methods: Thirty healthy BALB/C strain Mus musculus divided into 3 groups: first intervention group with statin only treatment (S), second intervention group with statin treatment plus MIPE using motorized treadmill (ST), and control (C) group with no statin and nor exercise. The duration of treatmentwas 28 days. Statin treatment dose was 2.06mg/kg bodyweight. Measurement caspase-3 was done by immunohistochemistry evaluation and the expression of capase-3 was calculated by cells count which expressing caspase-3.Results: There were more muscle cells expressing caspase-3 in the S group (47.00±12.92cells) than the C group (2.70±1.94 cells); p=0.000, the ST group (21.44±10.13 cells) than the C group (p=0.001), as well as S group and the ST group (p=0.000).Conclusion: Moderate intensity physical exercise can decrease caspase-3 expression in statin treated subject.Keywords: apoptosis, caspase-3, dyslipidemia, moderate intensity physical exercise, statin.
Co-Authors A.A. Ketut Agung Cahyawan W Agung Dwi Wahyu Widodo Agustin Nurliani Alief Yudo Astuti Aries Sasongko Astindari Astindari Astindari Astindari, Astindari Ayu Tyasmara Azarya Ibrahim Baiq Ratna Kumaladewi betty Agustina Tambunan, betty Agustina Brama Rachmantyo Budiono Budipramana, Vicky Sumarki Cita Rosita Sigit Prakoeswa Densy Violina Harnanti Desak Gede Agung Suprabawati Dian Eskaningrum Djoni Susanto Dwi Murtiastutik Endi Prilansa Mahadi Erlina Erlina Faizah, Zakiyatul Fanny Gunawan Firda Azizah Grace Ariani Hartecia, Gilda Heny Arwati Heryawati Heryawati I Wayan Yudiana Ida Septika Wulansari INDROPO AGUSNI Irene Lingkan Parengkuan Iswinarno Doso Saputro iwan Syarif Jimmy Hadi Widjaja Jonan, Bernadetta Junita Jeanne Paliman Kartika Arum Wardani Kholida Nur Aini Kintan Putri LaleMaulin Prihatina Linda Astari M. Yulianto Listiawan Marina Rimadhani Marina Rimadhani Martha Kurnia Kusumawardani Maylita Sari Maylita Sari, Maylita Meita Ardini Pratamasari Muhammad Miftahussurur Nanda Amalia Ramadhanti Navisa, Claudia Clary Novia Indriyani Adisty Nurina Hasanatuludhhiyah Nurul Wiqoyah, Nurul Poernomo, Adinda Sandya Priangga Adi Wiratama PUNGKY MULAWARDHANA, PUNGKY Purwati Purwati Purwati Puteri, Agnes Ilene Suprapto R. Heru Prasetyo R.A. Astrid Putri Wandhita Rahel Yuana Sadikim Ratna Darjanti Haryadi Regina Martina Cilik Rizaldi, Fikri Rulisiana Widodo Rusdamayanti Rusdamayanti Rwahita Satyawati Dharmanta Ryski Meilia Novarina, Ryski Meilia Sabilal Alif Sari, Festi Artika savitri, Lisa Sawitri Sawitri Sawitri Sawitri Soilia Fertilita Sunarso Suyoso Sunaryo Hardjowijoto Tessy Badriyah, Tessy Theresia Fifi Judikristiani Tri Hartini Yuliawati Trisniartami Setyaningrum Tyasmara, Ayu Ummi Maimunah Vinna Chrisdianti Widati Fatmaningrum Wilda Fitria Rachmadina Windya Tri Hapsari Winona May Hendrata Wiratama, Priangga Adi Yusfita Evi Rosdiana