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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Higea Majalah Farmasetika Medical Sains : Jurnal Ilmiah Kefarmasian
Erizal Zaini
Departemen Farmasetik, Fakultas Farmasi, Universitas Andalas, Padang 25163
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Journal : Jurnal Farmasi Higea

 1 
Studi Sistem Dispersi Padat Asam Mefenamat Menggunakan Polivinilpirolidon K-30 Maria Dona Octavia; Erizal Zaini; Vina Oktavia
Jurnal Farmasi Higea Vol 7, No 2 (2015)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (670.647 KB) | DOI: 10.52689/higea.v7i2.128

Abstract

Mefenamic acid was categorized as Non-Steroidal Anti-Inflamatory Drugs (NSAIDs) which has useful as analgesic, anti inflammatory, and antypiretic effect but it has poor solubility in water. The aim of this study was to increase the dissolution rate of mefenamic acid in a solid dispersion system which made by solvent method. Solid dispersion and physical mixture prepared with ratio 1:1, 1:3, and 1:5. Solid dispersion was prepared by solvent method Preparation of solid dispersion mefenamat acid – PVP-K30 in formula 1:3 was increased of dissolution significantly.  Characterization of Solid dispersion Mefenamic Acid with Polyvinylpyrrolidone used Scanning Electron Microscopy (SEM), X-Ray, Spectroscopy IR, Differentyal Thermal Analysis (DTA). The result of X-ray diffraction characterization the dissolution Mefenamic Acid-Polyvinylpyrrolidone in which the intensity is visible. The characterization with DTA showed a change in the peak of Mefenamic Acid where the endoterm, the characterization using infrared spectroscopy shows no functional group interaction between Mefenamic Acid and Polyvinylpyrrolidone.
Studi Sistem Dispersi Padat Meloksikam Menggunakan Hiroksipropil Metilselulosa (HPMC) 6 Centipoise (CPS) Erizal Zaini; Maria Dona Octavia; Kiki Rizky Wirza
Jurnal Farmasi Higea Vol 4, No 2 (2012)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (574.196 KB) | DOI: 10.52689/higea.v4i2.63

Abstract

The solid dispersion system of meloxicam-hydroxypropyl methylcelluloce (HPMC) 6 centipoise (cps) had been studied. The solid dispersion system was prepared by solvation method with several combination of meloxicam and HPMC were 1:1, 1:3 and 1:5. The physical mixture of meloxicam and HPMC with similar composition were used as standard. The powder of solid dispersion system and physical mixture were evaluated by X-ray powder diffraction, thermal (DTA), SEM and FT-IR spectroscopy analysis. The dissolution studies were carried out in USP type II apparatus. The result of X-ray powder diffraction analysis showed that the solid dispersion of  meloxicam with HPMC decreased the drug crystallinity. The endothermic peak of meloxicam from solid dispersion products shifted to lower temperature and peak intensity decreased significantly. X-ray powder diffraction and DTA indicated transformation of crystalline state of meloxicam to amorphous one by solid dispersion with HPMC. SEM results showed the solid dispersion of meloxicam and HPMC has agglomerates form. FT-IR spectra indicated no chemical interaction between meloxicam and HPMC in the solid dispersion. The highest in dissolution rate was observed with solid dispersion products of meloxicam and HPMC with ratio 1:5 (94,083 %) compared to pure meloxicam and its physical mixture.
Peningkatan Laju Disolusi Sistem Dispersi Padat Ibuprofen – PEG 6000 Auzal Halim; Elvi Rahma Yulisman; Erizal Zaini
Jurnal Farmasi Higea Vol 5, No 2 (2013)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (786.399 KB) | DOI: 10.52689/higea.v5i2.83

Abstract

It has done research on increasing the dissolution rate of solid dispersion system Ibuprofen with polymer Polyethylenglycols 6000 (PEG 6000). Solid dispersion system prepared by melting method with a ratio of raw materials Ibuprofen - PEG 6000, namely : 6:4, 7:3, 8:2, and 9:1. As a comparison was made with the physical mixture of the same composition. The powder mixture of physics and solid dispersion system properties of solids characterized by spectroscopic analysis, SEM analysis, DTA analysis, and X-ray diffraction analysis. Dissolution test method is determined by a basket. The results showed that the powder solid dispersion system can improve the physicochemical properties of Ibuprofen. Dissolution profiles showed that the 7:3 solid dispersion system powder in the 45th minute to increase the dissolution rate compared to the powder mixture of physics.
Co-Authors -, Salman Adhitya Jessica Agusri Boestari Akmal Djamaan Amri Bakhtiar Annisa Agustina Asiska Permata Dewi Asiska Permata Dewi Asiska Permatadewi Auzal Halim Auzal Halim Ben, Elfi Sahlan Deni Anggraini Deni Noviza Dhea Sultana Lutfiyah Dwi Setyawan Ellyza Nasrul Elvi Rahma Yulisman Elvita Sari Fauzi Saputra Fifi Harmely Friardi Ismed Gaesari, Sherly Rahmah Habibie Deswilyaz Ghiffari Hansen Nasif Helen Sonita Helen Sonita Henny Lucida Hulwa Salsabila Ima Kurniati Irna Kurniati Kiki Rizky Wirza Kurniati, Irna Lili Fitriani Mai Efdi Maria Dona Octavia Melisa Melisa Melzi Octaviani Muhammad Taher Muthia Fadhila Najmi Hilaliyati Netty Novitasari Novica Sari Rahmadevi Rahmi Nofita Resva Meinisasti, Resva Rifka Naura Rini Agustin Rose Intan Perma Sari Rustini Rustini Rustini Rustini S, Agnes Salman - Salman - Salman Salman Salman Umar Salman Umar Sundani N. Soewandhi Sundani N. Soewandhi, Sundani N. Syofyan Syofyan SYUKRAN HAMDENI Syukriati Chaira Trisfa Augia Uswatul Hasanah Verlia Nisrina Putri Vike Zulia Putri Vina Oktavia Yeni Novita Sari Yeyet C. Sumirtapura Yufri Aldi Yuska Noviyanty Zahara Gayo Zulhadjri Zulhadjri