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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Higea Majalah Farmasetika Medical Sains : Jurnal Ilmiah Kefarmasian
Erizal Zaini
Departemen Farmasetik, Fakultas Farmasi, Universitas Andalas, Padang 25163
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Journal : Jurnal Sains dan Teknologi Farmasi

 1 
UJI BIODEGRADASI FILEM PLASTIK CAMPURAN POLISTIREN DENGAN POLI(3 HIDROKSIBUTIRAT-KO-3-HIDROKSIVALERAT) DALAM LUMPUR Dewi, Asiska Permata; Octaviani, Melzi; Rustini, Rustini; Zaini, Erizal; Djamaan, Akmal
Jurnal Sains dan Teknologi Farmasi Vol 17, No 1 (2012)
Publisher : Universitas Andalas

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Abstract

An assay of biodegradation of plastic film combination of polystyrene (PS) and poli (3-hydroxy butyrate-ko-3-hydroxyvalerate) [P(3HB-ko-3HV)] has been conducted. The assay was done by using soil burial test method. The plastic film was made by blending technique of various composition of PS/P(3HB-ko-3HV) in to the mud. The remaining weight of plastic film was determined gravimentically time intervals 1,2,3,4 and 5 weeks of burial. Result showed that the P(3HB-ko-3HV) had an influence on the degradation rate of plastic film. The biodegradation rate increased with an increase in P(3HB-ko-3HV) content in the mixture. The rate was derived from linear regression equation and parameters such as biodegradation rate constant (k), t 50 % and t 95% were obtained. It was found that for combination of  PS/P(3HB-ko-3HV) 95:5 k= 1,26% b/b per week , t 50 % = 39,07 weeks and t 95 % = 74,783 week for the mixture of PS/P(3HB-ko-3HV) 90:10  k = 1,604 % b/b per week, t 50 % = 30,57 week and t 95 % = 58,62 week. For the mixture of PS/P(3HB-ko-3HV), 85:15 k = 2,663 % b/b per week, t 50 % = 17,95 week and t 95 % = 34,85 week. While those of pure PS plastic film k = 0,24 % b/b per week, t 50 % = 201,85 week and t 95 % = 354,55 week which indicated a very slow biodegradation. Analysis by SEM showed that the surface of plastic film was eroded and damaged during the burial. The amount of bacterial colony per 1 gram of mud was 2,31x107.
Uji Dissolusi Terbanding Tablet Metilprednisolon Generik Bermerek dan Generik Berlogo Dibandingkan Dengan Tablet Metilprednisolon Paten Nasif, Hansen; Zaini, Erizal; S, Agnes
Jurnal Sains dan Teknologi Farmasi Vol 19 No Supl1 (2017): Vol 19 Supplement 1, December 2017
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Obat generik adalah obat yang telah habis masa patennya dan kemudian dapat diproduksi oleh industri yang berbeda dari perusahaan inovatornya. Kontroversi tentang penggunaan obat Paten/ obat original dan obat generik/ obat copyan telah berlangsung lama di masyarakat, termasuk pada praktisi kesehatan walaupun penelitian pada fase biofarmasetik dan farmakokinetik telah banyak dilakukan. Pada studi biofarmasetik, perbedaan formulasi dan proses produksi obat dapat mempengaruhi ketersediaan obat dalam darah yang pada tahap selanjutnya akan mempengaruhi efek obat. Penelitian ini bertujuan mempelajari disolusi metilprednisolon 4 mg tablet generik bermerek dari produsen obat PT.B , generik berlogo dari PT.I dan obat paten dari PT.P. Kadar terdisolusi diukur menggunakan spektrofotometer UV-Vis pada panjang gelombang 200-400nm. Profil disolusi menunjukkan tidak adanya perbedaan bermakna untuk jenis obat paten/ inovator, generik bermerek dan generik berlogo diatas dengan similarity factor (F2 ) produk paten dengan generik bermerek adalah 86,9 dan produk paten dengan generik berlogo adalah 81,2,sehingga dapat disimpulkan bahwa profil disolusi ketiga jenis obat ini adalah sama.
Kajian Biodegradasi Filem Plastik Campuran Polimer Sintetik dengan Biopolimer dalam Larutan Air Octaviani, Melzi; Dewi, Asiska Permata; Boestari, Agusri; Zaini, Erizal; Djamaan, Akmal
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

A study on degradation of plastic film of the mixture of polystyrene sintetic polymers (PS) with poli(3-hidroxyibutirat) [P(3HB)] dan poli(3-hidroksibutirat-ko-3-hidroxyvalerat) [P(3HB-ko-3HV)] biopolymers in-vitro and in-vivo has been done. The assay was done by immersion test method in aquadest, river water at various pH of 4,6,8, and 10 respectively. Degradation rate was determined by linear regression with parameters including : t 50%, t 95% and rate constant (k). Degradation rate of plastic film of 1 PS/P(3HB) 95:5 at pH 6 was the fastest with k = 0,79 % week, t 50 % = 63,06 week and t 95 % = 119,84 week, followed by PS/P(3HB) 90 : 10 with k = 1,22 % / week, t 50 % = 41,25 week and t 95 % = 78,21 week and PS/P(3HB) 80 : 20 with k = 3,16 % week, t 50 % = 15,81 week and t 95 % = 30,05 week while pure PS plastic film (100 : 0 ) did not degraded at all. The degradation rate of a mixture of plastic film in river water, PS/P(3HB-ko-3HV) 95:5 showed k= 0,64 % week, t 50 % = 82,63 week and t 95 % = 157,17 week, PS/P(3HB-ko-3HV) 90:10 with k = 0,69 % week, t 50 % = 72,16 week and t 95 % = 137,4 week ; PS/P(3HB-ko-3HV) 85:15 with k = 0,74 %/week, t 50% = 66,79 week and t 95% = 127,32 week, while the pure PS plastic film (100:0) did not degrade.
Uji Biodegradasi Filem Plastik Campuran Polistiren dengan Poli(3 Hidroksibutirat-Ko-3-Hidroksivalerat) dalam Lumpur Dewi, Asiska Permata; Octaviani, Melzi; Rustini, Rustini; Zaini, Erizal; Djamaan, Akmal
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

An assay of biodegradation of plastic film combination of polystyrene (PS) and poli (3-hydroxy butyrate-ko-3-hydroxyvalerate) [P(3HB-ko-3HV)] has been conducted. The assay was done by using soil burial test method. The plastic film was made by blending technique of various composition of PS/P(3HB-ko-3HV) in to the mud. The remaining weight of plastic film was determined gravimentically time intervals 1,2,3,4 and 5 weeks of burial. Result showed that the P(3HB-ko-3HV) had an influence on the degradation rate of plastic film. The biodegradation rate increased with an increase in P(3HB-ko-3HV) content in the mixture. The rate was derived from linear regression equation and parameters such as biodegradation rate constant (k), t 50 % and t 95% were obtained. It was found that for combination of  PS/P(3HB-ko-3HV) 95:5 k= 1,26% b/b per week , t 50 % = 39,07 weeks and t 95 % = 74,783 week for the mixture of PS/P(3HB-ko-3HV) 90:10  k = 1,604 % b/b per week, t 50 % = 30,57 week and t 95 % = 58,62 week. For the mixture of PS/P(3HB-ko-3HV), 85:15 k = 2,663 % b/b per week, t 50 % = 17,95 week and t 95 % = 34,85 week. While those of pure PS plastic film k = 0,24 % b/b per week, t 50 % = 201,85 week and t 95 % = 354,55 week which indicated a very slow biodegradation. Analysis by SEM showed that the surface of plastic film was eroded and damaged during the burial. The amount of bacterial colony per 1 gram of mud was 2,31x107.
Co-Authors -, Salman Adhitya Jessica Agusri Boestari Akmal Djamaan Amri Bakhtiar Annisa Agustina Asiska Permata Dewi Asiska Permata Dewi Asiska Permatadewi Auzal Halim Auzal Halim Ben, Elfi Sahlan Deni Anggraini Deni Noviza Dhea Sultana Lutfiyah Dwi Setyawan Ellyza Nasrul Elvi Rahma Yulisman Elvita Sari Fauzi Saputra Fifi Harmely Friardi Ismed Gaesari, Sherly Rahmah Habibie Deswilyaz Ghiffari Hansen Nasif Helen Sonita Helen Sonita Henny Lucida Hulwa Salsabila Ima Kurniati Irna Kurniati Kiki Rizky Wirza Kurniati, Irna Lili Fitriani Mai Efdi Maria Dona Octavia Melisa Melisa Melzi Octaviani Muhammad Taher Muthia Fadhila Najmi Hilaliyati Netty Novitasari Novica Sari Rahmadevi Rahmi Nofita Resva Meinisasti, Resva Rifka Naura Rini Agustin Rose Intan Perma Sari Rustini Rustini Rustini Rustini S, Agnes Salman - Salman - Salman Salman Salman Umar Salman Umar Sundani N. Soewandhi Sundani N. Soewandhi, Sundani N. Syofyan Syofyan SYUKRAN HAMDENI Syukriati Chaira Trisfa Augia Uswatul Hasanah Verlia Nisrina Putri Vike Zulia Putri Vina Oktavia Yeni Novita Sari Yeyet C. Sumirtapura Yufri Aldi Yuska Noviyanty Zahara Gayo Zulhadjri Zulhadjri