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All Journal UNEJ e-Proceeding JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Journal of Tropical Pharmacy and Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline
Dewi Melani Hariyadi
Department Of Pharmaceutical Sciences, Faculty Of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Effect of Total Amount of Metformin HCl on the Characteristics of Metformin-Ca Alginate Microspheres Dewi Melani Hariyadi; Noorma Rosita; Tiara Jeni Rosadi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 5 No. 1 (2018): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (636.823 KB) | DOI: 10.20473/jfiki.v5i12018.13-19

Abstract

Introduction: Metformin hydrochloride (metformin HCl) is an antidiabetic drug that is specifically used for type 2 diabetes mellitus (DM) and belongs to the biguanide antidiabetic drugs. Objective: The aim of this research was to determine the effect of total amount of metformin HCl on the characteristics of metformin HCl-Ca alginate microspheres using aerosolization technique. Methods: The total amount of metformin were 0.5 g (F1); 1 g (F2); 1.5 g (F3) and 2 g (F4). Drug was encapsulated into alginate and was crosslinked using CaCl2. Results: The results showed that drug loadings were 5.09%; 9.61%; 13.11%; and 15.09% respectively, while the entrapment efficiencies were 48.35%; 41.99%; 38.67%; and 30.53%. The yields were 80.92%; 74.12%; 68.27%; and 59.11% respectively. Based on the statistical analysis, it was found that there were significant differences between formulas. Particles of formulas decreased as the amount of drug increased. The resulting sizes were 1.82 μm (F1); 1.96 μm (F2); 2.1 μm (F3); and  2.97 μm (F4). Conclusion: It can be concluded that amount of drug significantly affected the characteristics of metformin-alginate microspheres.
Effect of Sodium Alginate Concentration on Characteristics, Stability and Drug Release of Inhalation Quercetin Microspheres Tekla Kalalo; Andang Miatmoko; Hanafi Tanojo; Tristiana Erawati; Dewi Melani Hariyadi; Noorma Rosita
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.107-114

Abstract

Background: Quercetin is a flavonoid compound that has anti-inflammation activity. However, poor stability presents significant problems for the formulation into dosage forms. Microspheres are one of the potential lung delivery systems because of their ability to encapsulate various types of drugs, protect drugs from environmental effects and can release drugs in a sustained release. Objective: In the present study, the microsphere inhalation system of the anti-inflammation drug, quercetin was developed and evaluated to achieving the targeted delivery of these drugs to the lung. Method: The drug-loaded ca-alginate microspheres were prepared by aerosolization ionic gelation technique followed by freeze-drying. Result: The result of this study showed that particle size was less than 2 µm, the yield ranged from 41.33-76.14%, drug loading was less than 6%, entrapment efficiency ranged from 74.153% - 93.805% and flow properties showed that all formula had an excellent flow. Spherical microspheres were demonstrated by formulations containing 1 and 1.5% sodium alginate. A drug release study showed that the highest drug release of 30.649% was from the formulation with 2.5% sodium alginate, and the lowest drug release of 26.625% was from the formulation with 2% sodium alginate. , A stability study at temperatures of 25ᵒC and 40ᵒC for 28 days showed a decrease in drug loading and entrapment efficiency but an increase in particle size. The formulation containing 1.5% sodium alginate showed the optimal formula. Conclusion: These findings indicated that quercetin ca-alginate microspheres are the potential for inhalation to be delivered to the lung.
Co-Authors Abhimata Paramanandana Andang Miatmoko Ardhani Dwi Lestari1 Bambang Tri Purwanto Dewi Isadiartuti Dini Retnowati Dwi Setiawan Esti Hendradi Fauzia Azzahra Hanafi Tanojo I NYOMAN WIJAYA Idha Kusumawati Imamatin Nufus Melania Irawan, Mukhlis Bayu Irawan, Mukhlis Bayu Juni Ekowati Melanny Ika Sulistyowaty Mohammad Agus Sjamsur Rijal Mohammad Rizki Fadhil Pratama Muhamad Ilham Royyan Nafi’ Muhammad Faris Adrianto Noorma Rosita Praditapuspa, Ersanda Nurma Putri Hamidah Khairunnisa Rahmi Annisa Regia Nada Asshafa Retno Sari Rosita Handayani Rossa Auli Tasha Siti Rahmah Sugiyartono1 Suzana Tekla Kalalo Tiara Jeni Rosadi Tristiana Erawati Tutiek Purwanti Yusuf, Helmy