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All Journal Jurnal Veteriner Indonesia Medicus Veterinus Jurnal Ilmu Ternak Jurnal Agripet International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Perikanan dan Kelautan Jurnal Farmasi Klinik Indonesia Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan The Indonesian Biomedical Journal Creative Research Journal Majalah Farmasetika Jurnal Kedokteran Hewan
Mas Rizky A.A. Syamsunarno
Fakultas Kedokteran Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Veterinary Other

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Journal : Althea Medical Journal

 1 
Effects of Morinda citrifolia Leaf Extract on Glucose Absorption through Intestinal Epithelial Membrane in Wistar Rat Models Rikho Melga Shalim; Mas Rizky A. A. Syamsunarno; Muhammad Nurhalim Shahib
Althea Medical Journal Vol 4, No 4 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (732.495 KB) | DOI: 10.15850/amj.v4n4.1266

Abstract

Background: Noni fruit (Morinda citrifolia) has been used as herbal medicine by Indonesian people. However, the effect of noni leaves as an antihyperglycemic agent is still unknown. This study was conducted to find out the effect of Morinda citrifolia leaves on glucose absorption through intestinal epithelial membrane in wistar rat models.Methods: The study was conducted in November 2015 at the Biochemistry and Molecular Biology Laboratory Faculty of Medicine, Universitas Padjadjaran. We used in situ perfusion and rats were divided into 2 groups. The first group used glucose solution as a control. The second group used glucose with extracts. Specimens were taken before and after perfusion to check the amount of glucose with spectrophotometer. Statistical analysis using t-test was conducted to compare the total absorbed concentration of glucose from each group. Results: From calculation we found the kinetic value (Km) of glucose absorption without extract (Km=17.24) and with extract (Km=16.67). Statistical test showed there was no significant in results (p>0.05).Conclusions: There is no effect of Morinda citrifolia leaf extract on glucose absorption. However, kinetics of glucose absorption suggested a non-competitive inhibition by Morinda citrifolia leaf extract. 
Co-Authors Ahmad Kurniawan Aida Riyanti Alif Bagus Rakhimullah Alkaustariyah Lubis Alkaustariyah Lubis Alkaustariyah Lubis Alvin Yusuf Anisah Dahlan Arief Boediono Ariefqi, Muhammad Naufal Aziiz Mardanarian Rosdianto Aziiz Mardanarian Rosdianto Deru Indika Deru R Indika Dinar F. Agustin Djunaedi, Diah Dhianawaty Dwi Cipto Budinuryanto Dwi Wahyudha Wira Erick Khristian Fauziah, Nisa Gita Widya Pradini Grace Angelica Hanna Goenawan Henhen Heryaman Irma M. Puspitasari Irma Melyani Puspitasari Isa Mahendra Iwan Setiawan Jaqueline Sudiman Jeri Nobia Purnama Julia Windi Gunadi Julius Pangayoman Kikin Winangun Kikin Winangun Madeline Priscilla Maratul Mahdiyyah Masahiko Kurabayasi Mohammad Ghozali Mohammad Ghozali, Mohammad Muhammad Nurhalim Shahib Muhammad Rosyid Ridhlo Neni Anggraeni Nia Kania Norisca A. Putriana Norisca Aliza Putriana Nova Sylviana Ramdan Panigoro Rangga Setiawan Ratu Safitri Ratu Safitri Rikho Melga Shalim Rini Widyastuti Ronny Lesmana Roro Wahyudianingsih Rosdianto, Aziiz Mardanarian Sigit Prastowo Sony Heru Sumarsono Sony Heru Sumarsono Sony Heru Sumarsono TAKDIR SAILI Tatsuya Iso Tyagita Hartady Tyagita Tyagita Unang Supratman Uni Gamayani Winangun, Kikin Yulin Prisdiany Yuni Susanti Pratiwi