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Molekul: Jurnal Ilmiah Kimia

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Published by Universitas Jenderal Soedirman

ISSN : 19079761 EISSN : 25030310 DOI : -

Core Subject : Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry

MOLEKUL is a peer-reviewed journal of chemistry published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Jenderal Soedirman University, Indonesia. Publishing frequency 2 issues per year, on May and November. This Journal encompasses all branches of chemistry and its sub-disciplines including Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry.

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Articles 12 Documents

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Search results for , issue "Vol 13, No 1 (2018)" : 12 Documents clear

Interactions Between Environmental Factors and Zinc Concentrations in Porewater and Roots of Rhizophora sp. in Ampallas, Mamuju, West Sulawesi, Indonesia Rantih Isyrini; Shinta Werorilangi; Supriadi Mashoreng; Ahmad Faizal; Rastina Rachim; Akbar Tahir
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

The study was to determine the concentrations of Zn in porewater and fine roots of Rhizophora sp., and to examine their interactions with mangrove densities and physico-chemical. Porewater samples, fine roots, and sediments were collected in a 100 m2 plot at each site with different mangrove densities. The average Zn concentrations in mangrove roots in the study area were 0 – 58.21 mg/kg, suggested the capability of mangrove roots in retaining Zn. The average dissolved Zn concentrations in porewater were 0.63 mg/L – 3.50 mg/L, illustrated the amount of Zn bioavailable form and its potential release to the adjacent environment. The Zn concentrations in porewater did not correlate significantly with the densities of mangroves. The concentrations of Zn in roots increased as the densities were higher, which is possibly caused by the absence of mangrove at Site 1. The study discovered the important roles of organic content and silt/clay in Zn sorption thus affect Zn levels in porewater. The concentrations of Zn in mangrove roots increased as the pH of sediment and porewater decreased.

An Electrochemical Immunosensor for the Detection of B-Type Natriuretic Peptide (BNP) Based on Sandwich ELISA Using Screen Printed Carbon Electrodes Yeni Wahyuni Hartati; Muhammad Hilman Daniswara; Ratna Nurmalasari; Shabarni Gaffar; Toto Subroto
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

B-type natriuretic peptide (BNP) is a 32-amino acid polypeptide, a cardiac neuro hormone that specifically secreted from heart ventricle as a response towards the increase of volume and pressure in the heart. The determination of BNP concentration in patients blood is one of the method used to diagnose heart failure. An electrochemical immunosensor modified with the streptavidin/biotin system on screen printed carbon electrodes for the detection of the BNP antigen was developed in this study. Monoclonal anti-BNP capture antibody was immobilized on streptavidin-modified SPCEs to give a well oriented of antibody. Furthermore, a biotinylated anti-BNP that conjugated with horseradish peroxidase (HRP) was used as secondary antibody. The electrochemical signal produced by redox activity of substrate 3,3,5,5'-tetramethybezidine dihydrochloride (TMB/H2O2) was measured by differential pulse voltammetry. The BNP immunosensor showed a linear response between 1.0×10-2 and 1.0×102 ng/mL, and the limit of detection was 3.3 ng/mL. BNP immunosensor is a promising technology for the rapid and convenient detection of heart failure.

Flavon Compound from The Ethyl Acetate Extract of The Stem of Supit (Tetracera indica Merr.) Muharni Muharni; Elfita Elfita; Riska Adillah; Heni Yohandini; Julinar Julinar
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Tetracera indica Merr. in Musi Banyuasin, is one of the traditional medicine used by the community for the treatment of kidney stone disease and gout, but this claim is not recorded in the treatment of kidney stones and gout in Indonesia. In this study, isolation of antioxidant compound from ethyl acetate extracts of supit (Tetracera indica) was done. The isolation was carried out through step gradient polarity extraction, and separated and purified by chromatography technique. The determination of the structure of the isolated compound was performed by spectroscopy method including UV, IR, and NMR 1D and 2D, and antoxidant activity was determined by DPPH method. An active antioxidant compound was isolated from ethyl acetate extract in form of yellow solid (15 mg). Based on spectroscopic analysis the isolated compound was 5,8-dihydroxy-7-methoxyflavone. The compound showed strong antioxidant activity (IC50 8.25 μg/mL) higher than standard ascorbic acid (IC50 11.3 μg/mL). This data concluded that efficacy of supit (Tetracera indica) for the treatment related to antioxidant activity (uric acid) is proven by the identification of one antioxidant compound of this plant.

Ethanol Extract of Tithonia diversifolia (Hemsley) A Gray Standardized Ameliorates Hyperglycemia, Polyphagia, and Weight Loss in Diabetic Rats Yulia Fauziyah; Sunarti Sunarti; Ita Fauzia Hanoum; Mae Sri Hartati Wahyuningsih
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Diabetes mellitus is a state of chronic hyperglycemia which causes various complications. Traditionally, The Tithonia diversifolia (Hemsley) A Gray leaf has long been used for the treatment of diabetes. The aim of this study is to investigate the effect of the T. diversifolia leaf on blood glucose, polyphagia, and weight loss in a diabetic rat model. Rats were made diabetic with intraperitonial injection of Nicotinamide and Streptozotocin and divided into 5 groups. Group 1 were healthy rats, group 2 were diabetic rats, while groups 3, 4, and 5 were diabetic rats treated with 25, 50, and 100 mg/kg body weight of 70% ethanol extract of Tithonia diversifolia leaf respectively for 28 days. Blood was taken after treatment for measuring glucose. The ethanol extract of T. diversifolia leaf decreased blood glucose in diabetic rats (P<0.05). The ethanol extract of T. diversifolia leaf significantly suppresses polyphagia and improves diabetic rat weight (P <0.05). In conclusion, Tithonia diversifolia ethanolic extract has anti-hyperglycemic effect and ameliorated the effect of diabetes mellitus symptoms, namely polyphagia and weight loss.

Sesquiterpenoid Compounds from The Stembark of Aglaia minahassae (Meliaceae) Nunung Kurniasih; Hersa Milawati; Mohamad Fajar; Ace Tatang Hidayat; Rizky Abdulah; Desi Harneti; Unang Supratman; Mohamad Nurul Azmi
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Two sesquiterpenoid compounds, 4(15)-eudesmen-1b,6a-diol (1) and spathulenol (2) have been isolated from the stembark of Aglaia minahassae belong to Meliaceae family. The chemical structures of 1 and 2 were identified on the basis of spectroscopic evidence including UV, IR, NMR 1D, NMR 2D as well as mass spectra and by comparison with those previously reported spectra data. This compounds were isolated from this plant for the first time.

The Age Dependent Activities of Digestive Enzymes in Rasbora, Rasbora lateristriata Blkr., (Pisces: Cyprinidae) Untung Susilo; Purnama Sukardi; Ridwan Affandi
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

This study was to evaluate the digestive enzyme activity included a total protease, trypsin, chymotrypsin, lipase, amylase, cellulase and alkaline phosphatase in Rasbora. This research was carried out using three different ages (2, 4 and 6 months) and in each age consisted of six groups (replicates). In this study 150 fish (±2 months age), 120 fish (± 4 months age) and 90 fish (± 6 months age) were used. All digestion enzyme activity was measured by the spectrophotometric method, except the lipase activity was by the titration method. The results showed that the distinctness of age resulted in a significant difference on total protease, trypsin, lipase, cellulase and alkaline phosphatase (P <0.05), but no significant difference in amylase activity (P> 0.05). Total protease and trypsin activities were higher in fish of age two months than fish age four and six months, but the activity of lipase, cellulase and alkaline phosphatase were higher in fish age of four months compared to two months age fish. Fish, with distinct age has the different nutrient digestion capacity as expressed by differences in the activity of the enzyme digestion, except amylase. These results contribute to the future development of digestive physiology, especially in Rasbora.Key Words: alkaline phosphatase, carbohydrase, lipase, protease, Rasbora

Studies on Synthesis, Characterization, and Adsorption of Cationic Dyes from Aqueous Solutions Using Magnetic Composite Material from Natural Clay in Central Kalimantan, Indonesia I Made Sadiana; Karelius Karelius; Retno Agnestisia; Abdul Hadjranul Fatah
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Clay is a natural material from crystalline silicate with layered structures, has high cation exchange capacity, and large surface area. These advantages can be used as an adsorbent for the removal of contaminants in aqueous solutions, such as heavy metals and dyes. In Indonesia, clays from Java, Sulawesi, and Sumatra islands have been used as adsorbent, furniture, and construction materials. Due to limited information about basic characteristics of clay from Kalimantan, this clay has not been utilized well. Therefore, natural clay from Kalimantan, especially in Central Kalimantan, was used as adsorbent of cationic dyes in this present study. However, the clay has difficulty for separating the solid phase from aqueous solution after adsorption process. To solve this problem, combining clay with magnetic material was opted. The objectives of this study are to synthesize the magnetic composite material from natural clay by coprecipitation method and to characterize the synthesized magnetic composite material using an x-ray diffraction method, transmission electron microscopy, and vibrating sample magnetometer. The adsorption properties of the synthesized magnetic composite material were evaluated using rhodamine B and methylene blue dyes in aqueous solution. Before magnetic composite material was synthesized, the clay was previously being activated for removing impurities. The magnetic material formed in the structure of clay had magnetite with particle size of 2.75 nm and the magnetization value of 24.91emu/g. The adsorption capacities of natural clay, activated clay, and magnetic composite of clay in rhodamine B were 34.29, 76.27, and 81.46 mg/g, respectively, while in methylene blue were 30.25, 83.92, and 133.90 mg/g, respectively. These results suggested that magnetic composite of clay can increase the adsorption capacities against dyes and accelerate the separation of the adsorbent solid phase from aqueous solution with largest adsorption capacity on methylene blue dye.

Surface-enhanced Raman Scattering (SERS) Substrate of Colloidal Ag Nanoparticles Prepared by Laser Ablation for Ascorbic Acid Detection Teguh Endah Saraswati; Yudha Pratama Putra; Mohammad Rifqi Ihsan; Isnaeni Isnaeni; Yuliati Herbani
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Ag nanoparticles were synthesized by laser ablation using an Ag plate in distilled water. This method was performed using a laser with a wavelength of 532 nm and energy of 30 mJ for 60 min. Ag nanoparticles successfully formed, confirmed by the selected area electron diffraction (SAED) which revealed four principal crystal planes of (111), (200), (220) and (311). The size distribution of Ag nanoparticles ranged from 5 to 40 nm, as estimated from electron imaging observed by transmission electron microscope (TEM). Ascorbic acid was used as the analyte to test the characteristics of surface-enhanced Raman scattering (SERS) of colloidal Ag nanoparticles. The concentration of ascorbic acid (1.0, 0.5 and 0.25 wt%) and incubation time (0 and 6 h) were varied to determine the limit of detection and the effect of incubation time. The Raman scattering spectroscopy results showed that the colloidal Ag nanoparticle substrate improved the signals for detection of ascorbic acid.

Two Phenolic Compounds from Chloroform Fraction of Syzygium Polycephalum MIQ. Stem Bark (Myrtaceae) Tukiran Tukiran; Andika Pramudya Wardhana; Nurul Hidajati; Kuniyoshi Shimizu
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Syzygium polycephalum (Kupa) is a plant of the Myrtaceae family which is one of the endemic plants in Indonesia, commonly called as Gowok. The chemical components of the plant have not been reported so far. This study is intended to know the molecular structures of isolated compounds of chloroform fraction from S. polycephalum stem bark.The steam bark of the plant is dried, powdered and macerated with methanol to yield methanolic extract. The methanolic extract was then conducted to fractionation using hexane and chloroform to obtain hexane and chloroform fractions. The chloroform fraction was further subjected to separation using column chromatography to obtain pure isolates and followed by measuring of their spectroscopic evidences. The isolation of chloroform fraction had led to the findings of two pure isolates. Their structures of isolates were elucidated by extensive spectroscopic methods and by comparison with the literature data to gain two phenolic compounds that are gallic acid and 3,4,3’-tri-O-methylellagic acid.

The Interaction of Air Pollutant Molecules with Germanene and Silicene: a Density Functional Theory Study Muhammad Rifqi Al Fauzan; Wijayanti Dwi Astuti; Ghorby Al Fauzan; Sholihun Sholihun
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

We investigate the adsorption of atmospheric pollutants on germanene and silicene using density functional theory (DFT) calculations. In this study, we use carbon monoxide (CO) and nitric oxide (NO) as the pollutant molecules. Electronic properties of germanene and silicene are explored to obtain a good understanding in the adsorption process. Our calculation results show both germanene and silicene provide an identical mechanism of adsorption. Germanene and silicene adsorb CO and NO spontaneously with physisorption and chemisorption types for CO and NO molecules, respectively. We also conduct the Mulliken charges calculations to evaluate the transformation of atomic charges due to the adsorption process. From Mulliken charge calculation results we can confirm the existence of charge transfer between the adsorbent materials and the pollutant molecules. This phenomenon lies behind the occurrence of the adsorption process.

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Amin Fatoni

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Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

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Abstract

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Amin Fatoni

Contact Email aminfatoni@unsoed.ac.id

Phone -

Journal Mail Official j.molekul@gmail.com

Editorial Address Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location Kab. banyumas, Jawa tengah INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Amin Fatoni

Contact Email
aminfatoni@unsoed.ac.id

Phone
-

Journal Mail Official
j.molekul@gmail.com

Editorial Address
Jl. Dr. Soeparno No.61 Karangwangkal, Purwokerto, Jawa Tengah 53

Location
Kab. banyumas,

Jawa tengah

INDONESIA