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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Marinade Creative Research Journal JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Jamu Indonesia Pharmaceutical Sciences and Research (PSR)
Effionora Anwar
Universitas Indonesia
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Other

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Pembuatan Matriks dari Kompleks Polielektrolit Kitosan Pektin untuk Sediaan Tablet Mengapung Sagita, Erny; Anwar, Effionora; Surini, Silvia
Majalah Ilmu Kefarmasian Vol. 7, No. 3
Publisher : UI Scholars Hub

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Chitosan is a natural cationic polymer. That cationic property makes chitosan can form polyelectrolite complex (PEC) with anionic polymer. In this research, pectin was used as anionic polymer that interact ionically with chitosan. The aim of this research is to produce and characterize chitosan-pectin PEC that would be used as matrix in floating tablet. The solutions of chitosan and pectin 0,3% w/v were mixed in ratio 1:9, 3:7, 1:1, 7:3 and 9:1 with pH of the solution 4,5 and 5,0. The best condition to produce PEC was in pH 5,0 with ratio of chitosan and pectin = 3:7. The differences between chitosan-pectin PEC characteristic and its origin polymer were shown by functional group analysis, thermal analysis, swelling capacity and gel strength. The PEC was then used as matrix in floating tablet.
Pembuatan Niosom Berbasis Maltodekstrin DE 5-10 Dari Pati Singkong (Manihot utilissima) Jufri, Mahdi; Anwar, Effionora; Djajadisastra, Joshita
Majalah Ilmu Kefarmasian
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Niosomes are non ionic surfactant vesicles that have potential application in the delivery of hydrophobic or amphilic drugs. We developed proniosomes, a dry formulation using a maltodextrin as a carrier coated with non ionic surfactant, which can be used to produce niosomes within a minutes by addition of hot water followed by agitation. A novel method is reported here for rapid preparation of proniosomes with wide range of surfactant loading. Maltodextrin DE 5-10 was hidrolyzed from tapioca starch using Thermamyl L 120 da Novo at 85ºC. The result from SEM analyses shown that proniosomes appear very similar to the maltodextrin, but the surface was more smooth. Niosome suspensions which was observed under the optical microscopy and particle size analyzer were evaluated as drug carrier using ibuprofen as a model. The result provide an indication of maltodextrin DE 5-10 from tapioca starch are potentialy carrier in the proniosome preparation which can be used for producing niosomes.
Pemanfaatan Maltodekstrin Pati Terigu Sebagai Eksipien Dalam Formula Sediaan Tablet dan Niosom Anwar, Effionora; Djajadisastra, Joshita; Yanuar, Arry; Bahtiar, Anton
Majalah Ilmu Kefarmasian Vol. 1, No. 1
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The Use of Maltodextrin from Wheat Starch as an Exipient in Formula Tablet and Niosom dosage form. Wheat starch normally can be used as a tablet filler only, because the flow rate and binding capacity are not good enough. The wheat starch should be treated as follows : protein and amine free Bogasari wheat flour starch were hydrolyzed by α-amylase enzyme (Liquezym EX®) at variable temperature and time incubation to produce maltodextrin with different Dextrose Equivalent (DE) value. The maltodextrin could be used as tablet binder on wet granulation, tablet filler and binder on direct compress, a proniosom carrier to prepare niosom, a tablet filler, binder and disintegrator on direct compress tablet, a sugar coated tablet material. All of the product used active compound as amodel and the quality were evaluated according to the 4thed. of Indonesian Pharmacopeae and other valid references. The result shows that maltodextrin DE 1–5 could be used as a tablet binder which was processed by wet granulation on 2-5% concentration, as a tablet binder and filler which was processed by direct compress on 30-35%; maltodextrin DE 10-15 could be used as a proniosom carrier then continued to niosom preparation with surfactant composition of 2 mmol (1 mmol for span 60 and 1 mmol for cholesterol). The surfactant and drug concentration of 100 mmol/lt and 5 mmol/lt subsequently was proved to loading the drug as much as 81.28%. Maltodextrin DE 15-20 could be used as a tablet filler, binder and disintegrator at 84%, and starch hydrolyzed of DE 35-40 as a sugar coating which was more economical than sugar.
Pembuatan Sediaan Tablet Mengapung Famotidin Menggunakan Kompleks Polielektrolit Kitosan-Pektin Sebagai Bahan Matriks Sagita, Erny; Anwar, Effionora; Surini, Silvia
Majalah Ilmu Kefarmasian Vol. 8, No. 1
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Floating tablet is one of the drug delivery system retained in the stomach which aims to prolong the lag time of the drug in the stomach. This principle can be used to improve the efficacy of famotidine in treating diseases in the stomach The purpose of this research is to develop dosage form afloat by using Chitosan Pectin Electrolytes (PEC) as matrix then used as the matrix in tablet dosage form with famotidine as a drug model. PEC also combined with hydroxypropylmethylcellulose (HPMC) with different. PEC was also combined with hydroxypropilmethylcellulose (HPMC) in different concentrations. The results of the dissolution study showed that PEC could retard the release of famotidin for 10 hours. PEC in combination with HPMC could retard the release of famotidin for 20 hours. Tablet that only contains PEC as matrix could remain buoyant for 12 hours while tablet with combination of PEC and HPMC could remain buoyant for 24 hours.
Uji Stabilitas Fisik Formula Krim yang Mengandung Ekstrak Kacang Kedelai (Glycine max) Dewi, Rosmala; Anwar, Effionora; KS, Yunita
Pharmaceutical Sciences and Research
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Soybean extract has known for its antiaging potential. The addition of soybean extract was predicted can influence the physical stability of the cream. Therefore, this research was aimed to test the physical stability of cream contained soybean extract in different concentration (2%, 4%, 6%, and 8%). The physical stability test including the storage for eight weeks at room temperature, high temperature (40°±2°C), and low temperature (4°±2°C). Stability parameters were the organoleptic observation, pH, globul size, viscosity, and cycling test. Those four cream formula showed good stability in organoleptic, pH, globul size, viscosity, and cycling test.
Co-Authors . Chaidir . Harianto . Iskandarsyah, . Abdul Munim ABDUL MUN’IM Animar J Aswin Anisa Amalia Antokalina SV Antokalina SV, Antokalina ANTON BAHTIAR Anton Bahtiar Anton Bahtiar Arry Yanuar Ayun Erwina Arifianti Bahtiar, Anton Berna Elya Cahyaningsih, Umi Chaidir Chaidir Chaidir Chaidir DEVI RATNASARI DINA RAHMAWANTY Engkom Komariah Erny Sagita Erny Sagita Erny Sagita, Erny FADLINA CHANY Fadlina Chany Saputri FAUZIAH MAPPAMASING Firda Wery Ginanjar Pratama Harianto Harianto Henry . Joshita D Joshita Djajadisastra Joshita Djajadisastra Joshita Djajadisastra, Joshita Junaedi Junaedi Junaedi, . Junaedi, . KS, Yunita L B S.Kardono Liza Ariantina Mahdi Jufri Mahdi Jufri Mahdi Jufri Mala Nurilmala Nurjanah - - Nursanti Nursanti Nursanti Nursanti Putri Margaining Utami Putri Margaining Utami, Putri Margaining Raditya Iswandana Rahmawanty, Dina Rangga Pradana Rangga Pradana Rangga Pradana, Rangga Rizky Clarinta Putri Rosmala Dewi Rosmala Dewi Sabrina Dahlizar Salsabiela Haz Ekaputri Silvia Surini Silvia Surini Silvia Surini SITI MARDIYANTI Siti Sa’diah Taufik Hidayat Wanda Nisrina Aqilah Yanuarti, Rini Yoga Yuniadi Yunita K S Yunita K S Yunita K S