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All Journal Jurnal Kedokteran Syiah Kuala Folia Medica Indonesiana Transformasi: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Ilmiah Universitas Batanghari Jambi Journal Of Vocational Health Studies Jurnal Medik Veteriner JURNAL ILMU KEFARMASIAN INDONESIA Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology KESANS : International Journal of Health and Science

Danti Nur Indiastuti

Universitas Airlangga

Author-ID : 2617774

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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Resistance Patterns of Escherichia coli and Klebsiella pneumoniae Bacteria Against Amikacin, Ceftazidime, Meropenem, Nitrofurantoin Antibiotics in Elderly Patients with UTI in RSUD Dr. Soetomo Herdiyanti Herdiyanti; Lindawati Alimsardjono; Danti Nur Indiastuti
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 10 No. 1 (2019): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: Urinary tract infection (UTI) is an infection that involves the urinary tract, including the urethra, bladder, ureter, and kidneys. UTI is caused by microorganisms that breed in the urinary tract which are supposed to be free of microorganisms. Two bacterias that cause UTI in general are Escherichia coli and Klebsiella pneumoniae. UTI can occur at any age but generally occurs in the elderly. UTI caused by gram-negative bacteria can be killed with several examples of antibiotics namely amikacin, ceftazidime, meropenem and nitrofurantoin. These antibiotics found resistance to the bacteria that cause the UTI. This research is to determine the resistance patterns of Escherichia coli and Klebsiella pneumoniae bacteria against amikacin, ceftazidime, meropenem, nitrofurantoin antibiotics in elderly patients with UTI in Dr. Soetomo Surabaya January-June 2017 period.Methods: A descriptive retrospective study in accordance with the logbook data of Clinical Microbiology Installation at Dr. RSUD. Soetomo Surabaya. Data from this study were taken from all populations that met the inclusion criteria. The results are presented by tables. Results: There are 163 elderly patient data which diagnosed with urinary tract infection. Escherichia coli resistance pattern against ceftazidime (75.6%), nitrofurantoin (12.6%) and meropenem (2.4%). Meanwhile, Klebsiella pneumoniae against ceftazidime (72.2%), nitrofurantoin (55.6%), meropenem (11.1%) and amikacin (2.8%). Conclusion: There were resistance number of Escherichia coli and Klebsiella pneumoniae bacteria against antibiotics amikacin, ceftazidime, meropenem, nitrofurantoin in elderly patients with UTI.

Knowledge level of the Society about Fear of Missing Out Through Webinar in COVID-19 Pandemic Hersati Prasetyo; I Putu Agus Arsana; Mahrumi Dewi Tri Utami; Danti Nur Indiastuti
Jurnal KESANS : Kesehatan dan Sains Vol 1 No 5 (2022): KESANS : International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v1i5.44

The COVID-19 pandemic situation causes many people to be confined at home and triggers people to tend to spend more time accessing social media. Social media basically shows activities carried out by other people and this can trigger the phenomenon of Fear of Missing Out (FoMO). The purpose of this study is to know the level of knowledge of the Indonesian society about the FoMO and how to overcome it in the era of the COVID-19 pandemic. This study is a type of descriptive survey study; it describes the level of society knowledge about FoMO through webinars during the COVID-19 pandemic. The sample is 779 people who have met the inclusion and exclusion criteria. The data was obtained through a google form which was distributed to webinar participants, then processed and described in the form of a distribution table of respondents along with the average post-test results on a scale of 7 and 100 for the age group. The collected data were 779 respondents from different age groups (12-55 years). All existing age groups can answer more than half of the questions correctly. The average of questions answered correctly was almost the same in all age groups, with the 41–45-year-old group being in the top position. The average post-test result from all age ranges was 69.57. The average level of society knowledge about the FoMO phenomenon and how to solve it through webinar in the COVID-19 pandemic which was known from the post-test scores did not show much different results between each age range. This shows that all age ranges have the same susceptibility to experiencing FoMO.

PENGEMBANGAN KADER SEKOLAH MENENGAH UNTUK MENURUNKAN INSIDEN THALASSEMIA DI KABUPATEN BULAK, SURABAYA Annette d’Arqom; Danti Nur Indiastuti; Zamal Nasution; Rezi Ramawan Melbiarta
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 5 No. 2 (2021): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v5i2.2021.267-273

AbstrakThalaasemia merupakan penyakit genetik yang menyebabkan penurunan atau ketiadaan hemoglobin, yang disebabkan oleh mutasi genetik pada gen α dan/atau gen β globin. Gejala utamanya adalah anemia yang bervariasi dari sedang hingga berat yang memerlukan transfusi rutin setiap bulan. Memutus mata rantai atau pencegahan thalassemia adalah satu-satunya cara dalam menangani penyakit genetik ini. Selain itu, karena perkawinan usia muda (10-24 tahun) merupakan hal yang umum di Indonesia, maka diperlukan edukasi mengenai pengenalan status dan risiko penyakit ini sejak usia dini, sebelum menikah, untuk menghentikan bayi baru lahir penderita thalassemia mayor. Mengatasi masalah di atas membutuhkan penyebaran informasi dan pelatihan yang berkelanjutan. Salah satunya adalah SAHABAT THALER, yaitu: gerakan kader mahasiswa yang paham dan siap menyebarkan ilmu ke lingkungan dan sesama. Memanfaatkan kegiatan ekstrakurikuler seperti OSIS, PMR, Rohis, dll, diharapkan pengetahuan tentang Thalasemia dapat disebarluaskan secara efektif dan efisien, terutama kepada individu usia subur. Kegiatan inisiasi ini diawali dengan pelatihan online untuk 20 kader mahasiswa dan 1 dosen pembimbing. Pelatihan diberikan oleh para ahli Farmakologi Molekuler, Patologi Klinik, Psikiatri, dan orang tua penderita Thalassemia. Pelatihan tersebut meliputi mengenal dasar-dasar Thalassemia, terapi dan skrining Thalassemia, pentingnya donor darah, aspek psikososial Thalassemia, dan berbagi pengalaman orang tua penderita Thalassemia. Para kader kemudian dibagi menjadi 4 kelompok kecil dan dipandu oleh fasilitator untuk kemudian menonton film dokumenter tentang Thalassemia dan membuat proyek mandiri yang selanjutnya disebarluaskan kepada 83 rekan sejawat. Respon lengkap yang diterima berjumlah 17 dari 20 kader, dengan 35,29% responden pernah mendengar tentang Thalassemia dan tidak ada yang memiliki keluarga atau teman dengan Thalassamia. Namun mereka memiliki pengetahuan yang baik tentang Thalassemia sebelum pelatihan baik (rata-rata 90,16%, kisaran 66,67-100%) dan meningkat setelah pelatihan (rata-rata 91,67%, kisaran 83,33-100%). Usai pelatihan, empat produk yang terdiri dari dua video, satu Instagram, dan satu poster dibuat dan disebarluaskan kepada rekan sebaya. Pembinaan kader kelompok sebaya diperlukan untuk meningkatkan kesadaran penyakit genetik dan pentingnya skrining pranikah.Kata Kunci: kader SMU, Thalassemia, Teman SebayaAbstractThalassemia is a genetic disease that causes decreasing or absence of hemoglobin, caused by a genetic mutation in the alpha gene or/and beta-globin gene. The main symptom is anemia which varies from moderate to severe which requires regular transfusions every month. Breaking the chain of Thalassemia or prevention is the only way in dealing with this genetic disease. Moreover, since young marriage (10-24 years) is common in Indonesia, education is needed regarding the recognition of the status and risk of this disease from an early age, before marriage, to stop the newborn with Thalassemia major. Addressing the above problems requires continuous information dissemination and training. One of these efforts is SAHABAT THALER, which is the movement of student cadres who understand and are ready to spread knowledge to the environment and peers. Taking advantage of extracurricular activities, knowledge of Thalassemia is expected to be effectively and efficiently disseminated, especially to individuals of childbearing age. This initiation activity began with online training for 20 student cadres and 1 supervisor. Training is provided by experts in Molecular Pharmacology, Clinical Pathology, Psychiatry, and parents of Thalassemia patients. The training includes getting to know the basics of Thalassemia, therapy, and screening for Thalassemia, the importance of blood donation, psychosocial aspects of Thalassemia, and sharing experiences of parents with Thalassemia. The cadres were then divided into 4 small groups and guided by the facilitator to then watch a documentary film about Thalassemia and create an independent project which was further disseminated to 83 peers. From 20 cadres, 17 complete response was received. From the response, 35.29% ever hear about Thalassemia and no one has family or friends with Thalassemia. However, they have a good knowledge of Thalassemia before the training is good (mean 90.16%, range 66.67-100%) and increase after the training (mean 91.67%, range 83.33-100%). After the training, four products which are two videos, one Instagram, and one poster were created and disseminated to the peers. The development of peer group cadres is necessary to increase the awareness of the genetic disease and the importance of pre-marital screening.Keyword: High School cadre, Peers, Thalassemia

Skrining Pendahuluan Toksisitas Beberapa Tumbuhan Benalu terhadap Larva Udang Artemia Salina Leach DANTI NUR INDIASTUTI; SRI PURWANINGSIH; YUANI SETIAWATI; NOOR CHOLIES
JURNAL ILMU KEFARMASIAN INDONESIA Vol 6 No 2 (2008): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1138.28 KB)

The brine shrimp lethality test (BSLT) is considered as a useful tool for preliminary assessment of toxicity. It has also been suggested for screening of pharmacological activities of plant extracts. The bioactivity of eight methanol extracts of four parasite plants and two host plants were evaluated using the brine shrimp lethality assay. The results showed that all methanol extracts of the host plants did not have any indication of toxicity The LC50 of methanol extract of Moringa pterygosperma stem was 1085.44±84.32 µg/ml, and of Ficus refusal stem was 1240.86±50.71 µg/ml. But methanol extracts of whole parts of parasite plants showed toxicity to Artemia Salina Leach. The LC50 of methanol extract of Loranthus peretandrus herb parasite was 175.66±29,24 µg/ml while that of Elytranthe evenia leaf parasite was 327.15±38.66 µg/ml; of Elytranthe evenia stem parasite was 320.39±39.57 µg/ml; of Elytranthe evenia flower parasite was 456.79±15.69 µg/ml; of Scurulla atropurpurea herb parasite was 176.44±28.46 µg/ml; and of Viscum articulatum parasite was 53.79±10.83 µg/ml.

Efek Analgesik Ekstrak Etanol Zingiber cassumunar Roxb. pada Mencit dengan Metode Writhing Test Qonita Bajuber; Danti Nur Indiastuti; Edward Kusuma
Jurnal Medik Veteriner Vol. 3 No. 1 (2020): April
Publisher : Faculty of Veterinary Medicine, Universitas Airlangga

Penelitian bertujuan untuk menguji efek analgesik ekstrak etanol Zingiber cassumunar Roxb. pada mencit yang diinduksi dengan asam asetat. Penelitian ini merupakan penelitian eksperiment posttest only control design, menggunakan metode writhing test. Sampel penelitian terdiri dari 25 mencit terbagi dalam tiga kelompok perlakuan ekstrak Zingiber cassumunar Roxb.; P1, P2, dan P3, dengan masing-masing dosis 100 mg/kgBB, 200 mg/kgBB, 400 mg/kgBB, kelompok kontrol negatif aquades (K-), serta kelompok kontrol positif aspirin (K+). Hasil penelitian menunjukkan bahwa (P1) dan (P2) signifikan menurunkan jumlah geliat pada mencit dibandingkan (K-) (p < 0,05), dengan persentase penurunan jumlah geliat sebesar 49,53% dan 57,01%, sedangkan (P3) tidak menunjukkan aktivitas analgesik. Ekstrak Zingiber cassumunar Roxb. dosis 100 mg/kgBB dan 200 mg/kgBB tidak memiliki perbedaan yang signifikan terhadap (K+) untuk mengurangi rasa nyeri.

INHIBITORY ACTIVITY OF ALLIUM SATIVUM L. EXTRACT AGAINST STREPTOCOCCUS PYOGENES AND PSEUDOMONAS AERUGINOSA Natasha Hana Savitri; Danti Nur Indiastuti; Manik Retno Wahyunitasari
Journal of Vocational Health Studies Vol. 3 No. 2 (2019): November 2019 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Background: One of the most common health problems is infectious diseases. Infectious disease can be caused by bacteria. There were two groups of bacteria based on the staining, Gram-positive and Gram-negative bacteria. Purpose: Antibiotics are the main therapy used in the incidence of bacterial infections. But over time, some antibiotics became resistance. Several studies have shown that garlic has an antibacterial effect. The content of allicin, ajoene, saponins, and flavonoids is found in garlic which has antibacterial properties. The antibiotic activity test of garlic was carried out on the bacteria Streptococcus pyogenes and Pseudomonas aeruginosa. The goal of this study is to investigate the antibacterial effect of Allium sativum L. extract against Streptococcus pyogenes and Pseudomonas aeruginosa. Methods: Garlic extract was made using the maceration method using 96% alcohol as the solvent. Tube dilution method elected to observe garlic antibiotic activity. This test aims to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). There were eight different concentration used, i.e. 2 grams/ml, 1 gram/ml, 0.5 gram/ml, 0.25 gram/ml, 0.125 gram/ml, 0.0625 gram/ml, 0.03125 gram/ml, and 0.015625 gram/ml. Replication is done three times. Results: In this experiment, the extract produced was turbid that MIC could not be determined and there was no momentous differentiation between before and after treatment. There was no growth of Streptococcus pyogenes in 1 gram/ml and Pseudomonas aeruginosa in 0.5 gram/ml. This number indicates the MBC for each bacteria. Conclusion: Garlic (Allium sativum L.) has an effect of bactericidal activity, it can perform as an antibacterial for Streptococcus pyogenes and Pseudomonas aeruginosa. Garlic extract was more effective for Pseudomonas aeruginosa than Streptococcus pyogenes.

Co-Authors Abdurrahman Hasyim Asy’ari Agung Dwi Wahyu Widodo Alimsardjono, Lindawati Anastassya Yuniar Setyo Putri Annette dÃ¢Â€Â™Arqom, Annette Arthur Pohan Kawilarang Bakhtiar, Arief Desi Rahmah Sari Dewangga Sakti Satria Kinasih Dinda Divamillenia Dini Indah Berlianti Edward Kusuma Gabriel Pedro Mudjianto Gondo Mastutik Hamzah Hamzah Herdiyanti Herdiyanti Hersati Prasetyo I Putu Agus Arsana Indri Safitri Mukono Jihan Nur Fauziah Jonathan Christianto Sutadji Mahrumi Dewi Tri Utami Manik Retno Wahyunitasari Margareth Ayu Caroline Pangkerego Mariska Nuriana Mia Ratwita Andarsini Muhammad Hafizh Muhammad Raihan Habibi Nabil Alfin Juhri Natasha Hana Savitri Natasya Ariesta Selyardi Putri NOOR CHOLIES Octaviana Galuh Pratiwi Pascalis Fabian Peter Asa Purwanta, Marijam Qonita Bajuber Rebekah Setiabudi, Rebekah Resti Yudhawati Rezi Ramawan Melbiarta Rezy Ramawan Melbiarta Shaohong Lai Shofiuddin Al Mufid Sri Purwaningsih Sri Ratna Dwiningshih Trisnawati Trisnawati Wiwin Retnowati Yuani Setiawati Zamal Nasution

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