Article Per Year (5 Year)
p-Index From 2019 - 2024
4.63
P-Index
This Author published in this journals
All Journal Medicina journal of internal medicine Sport and Fitness Journal Buletin Udayana Mengabdi E-Jurnal Medika Udayana Jurnal Kesehatan Jurnal Kesehatan Andalas Majalah Obat Tradisional Journal of Medicine and Health ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal Essential: Essence of Scientific Medical Journal Bali Dental Journal
Desak Made Wihandani
Bagian Biokimia, Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

Published : 45 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Journal of Medicine and Health

 1 
Kombinasi Nanopartikel Cisplatin-Withaferin Berbasis PEGylated Liposome Sebagai Terapi Alternatif Kanker Ovarium Made VW Yani; Ida Ayu W Anjani; I Gede S Narayana; Desak M Wihandani; I Gede P Supadmanaba
Journal of Medicine and Health Vol. 2 No. 5 (2020)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (820.434 KB) | DOI: 10.28932/jmh.v2i5.1129

Abstract

Ovarian cancer is one of the major health problems in gynecology worldwide. Globocan 2012 data shows that ovarian cancer occurs in 239.000 cases, and is placed fourth as the most malignancy occurred in Indonesia. So far, cisplatin is the most effective therapeutic agent, but the high dosage of administration often caused side effects. A new alternative therapy to overcome the problems by using withaferin-A and nanoparticle PEGylated liposome. WFA has the potential effect to reduce cisplatin resistance but has low bioavailability thus, it needs to be encapsulated. This review’s goal is to depict the potency of withaferin-A, cisplatin, and PEGylated liposome combination as a therapeutic agent to treat ovarian cancer. The combination of Cisplatin-Withaferin PEGylated Liposome is constructed by the modified thin lipid film hydration method then administered orally. This combination suppresses 70-80% of the ovarian cancer cell growth in vivo and inhibits NGFR from binding to TRKA, prevents cell migration as much as 50%. Nano-Cisferin-Liposome, inhibits migration of ovarian cancer cell significantly through ?-catenin signaling through ALDH1 that disturb the spheroid formation, and increase apoptosis event as much 70-80% by increasing ROS production up to 2,5 times. Thus, Nano-Cisferin-Liposome (NCL) has potential as a therapeutic agent for treating ovarian cancer. Keywords: Cisplatin; Ovarian Cancer; PEGylated Liposome; Withaferin A
Co-Authors , I Komang Wira Ananta Kusuma Adi Saputra Adioka GM Agung Nova Mahendra AGUS BAGIADA NYOMAN Anak Agung Bagus Putra Indrakusuma Anak Agung Bagus Putra Indrakusuma Anak Agung Gede Eka Septian Utama Anak Agung Istri Shania Kemala Anak Agung Ngurah Krisnanta Adnyana Andrean Heryanto Anggi Amanda Triana Devy Anthony Wijaya Arcana N Arim Sadeva, I Gede Krisna Audrey Rachel Wijaya Avissia Zivanna Bagus Komang Satriyasa Baiq Rissa Khaerawati Salim Bayu Mahendra Christine Beatrice Amesiella Cokorda Bagus Jaya Lesmana Dady Iskandar Gede Andry Nicolas Andry Nicolas I A Md Dwi Purwitasari I Dewa Putu Sutjana I G. P. Supadmanaba I Gede Arya Diva Dhananjaya I Gede Aswin Parisya Sasmana I Gede Krisna Arim Sadeva I Gede Krisna Arim Sadeva I Gede S Narayana I Gede Wikania Wira Wiguna I Gusti Ayu Stiti Sadvika I Kadek Arya Gangga Permana I Ketut Agus Somia I Komang Wira Ananta Kusuma I Made Adi Widiantara I Made Angga Sayoga I Made Jawi I MADE MULIARTA . I Made Winarsa Ruma I Nyoman Wande I W. Sudarsa I Wayan Gede Sutadarma I Wayan Gede Sutadarma I Wayan Gede Sutadarma I Wayan Gede Sutadarma I Wayan Surudarma I Wayan Surudarma I Wayan Weta I Wayan Windi Artha I.A. Pascha Paramurthi Ida Ayu Dewi Wiryanthini Ida Ayu W Anjani Ida Ayu Widya Anjani Ida AyuWidya Anjani Ida Sri Iswari Indra Lesmana Indrakusuma, Anak Agung Bagus Putra Janet Tee Katrin ** Kausalya Neelamagam Ketut Agus Adrianta Ketut Ayu Hartarani Prasetya Ketut Tirtayasa Komang Erdwin Wicaksana Listya Triandari Luh Made Indah Sri Handari Adiputra Luh Made Mas Rusyati Luh Putu Ratna Sundari M.Ali Imron Made Ngurah Arya Diningrat Pinatih Made VW Yani Made Wahyu Krisnandewi Muh. Ali Imron Muhammad Ali Imron Muhammad Irfan Muhammad Irfan Ni Kadek Fiora Rena Pertiwi Ni Kadek Yudit Erawati Ni Made Ari Purwaningrum Ni Made Ayu Adnyani Ni Made Dwi Putri Nadi Ni Made Suasti Wulanyani Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Putu Sri Indrani Remitha NN Ayu Dewi NYOMAN AGUS BAGIADA Prima Saraswati Sanjiwani Sudarsa Putri Ayu Wulandari Putri Ayu Wulandari Putri Ayu Wulandari, Putri Ayu Putu Anda Tusta Adiputra Putu Astawa Rubahshini Gunaseelan Sabrina Annamma Philip Shenbagam Mahalingam Sinta Wiranata Sugijanto - Sugijanto - Susy Purnawati Tjokorda Gde Bagus Mahadewa Widya Anjani, Ida Ayu Yudha Anggoro Kawi