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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Higea Majalah Farmasetika Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian

Erizal Zaini

Departemen Farmasetik, Fakultas Farmasi, Universitas Andalas, Padang 25163

Author-ID : 448018

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Pelepasan Ibuprofen dari Gel Karbomer 940 Kokristal Ibuprofen-Nikotinamida Rini Agustin; Novica Sari; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

One of the methods to increase the solubility is co-crystalization. As Ibuprofen can be used in topical application for rheumatoid arthritis, a study about formulation and release of ibuprofen-nicotinamide co-crystal in carbomer gel had been conducted. Co-crystal was obtained from a dissolve method, which ibuprofen and nicotinamida were mixed with equimol composition (1:1). Gel consisted of two formulas with the same amount of ibuprofen (5%). The first formula was gel co-crystal ibuprofen-nicotinamide and the second formula was pure ibuprofen. The basis used was carbormer 940. The release test was done using the horizontal type of Franz diffusion cell and measured using HPLC (High Performance Liquid Chromatography) with mobile phase of methanol: aquabidest (80:20) pH 3.5 with orthophosphate acid. The results showed both formulas were not stable in homogeneity aspect for several storage days. Separation was occurred at low and high temperatures. The result of release profiles at the 120th minutes was 4.4793 % and 4.4293 % and the release efficiencies were 3.8891 and 3.8612. The statistic analysis showed that release efficiencies of both formulas were not significantly different (p>0.05) using One-Way ANOVA. In a conclusion, the process of making gel of co-crystal ibuprofen-nicotinamide did not influenced ibuprofen release in gel preparation.

Studi Awal Sediaan Gel Ekstrak Etanol Kayu Angin (Usnea Sp) untuk Penyembuhan Luka Bakar Lili Fitriani; Fauzi Saputra; Melisa Melisa; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 5, No 2 (2018): J Sains Farm Klin 5(2), Agustus 2018
Publisher : Fakultas Farmasi Universitas Andalas

Telah dilakukan studi awal formulasi dari ekstrak etanol kayu angin (Usnea sp) dalam bentuk sediaan gel dan uji efektivitas sediaan gel terhadap penyembuhan luka bakar pada mencit. Sediaan gel dibuat menggunakan hidroksipropil metilselulosa (HPMC) sebagai gelling agent. Gel dibuat dalam dua formula yaitu tanpa mengunakan ekstrak etanol Usnea sp (F1) dan mengunakan ekstrak etanol Usnea sp sebanyak 1% (F2). Evaluasi gel berupa organoleptis, homogenitas, pemeriksaan pH, uji daya sebar dan iritasi kulit. Uji aktivitas luka bakar dilakukan pada tiga kelompok hewan uji dimana masing-masing kelompok terdiri dari lima ekor mencit. Hasil penelitian menunjukkan bahwa ekstrak etanol kayu angin dapat dijadikan sebagai gel. Uji organoleptis gel ekstrak etanol kayu angin menunjukkan gel homogen dengan pH 5 - 5,5 dandaya sebar 5,6 – 6 cm2. Uji iritasi pada kulit menunjukkan hasil tidak terjadi iritasi pada kulit. Hasil uji aktivitas penyembuhan luka bakar menunjukkan bahwa kelompok hewan uji yang diberikan sediaan gel yang mengandung ekstrak etanol Usnea sp mampu menyembuhkan luka bakar lebih cepat dibandingkan dengan kelompok hewan uji yang diberikan sediaan gel tanpa ekstrak dan kelompok hewan uji tanpa perlakuan (kontrol). Hasil studi awal ini menunjukkan bahwa ekstak etanol Usnea sp dapat dibuat dalam bentuk gel dan dapat mempercepat proses penyembuhan luka bakar.

Evaluasi Pengelolaan Obat pada Puskesmas di Kota Pariaman Syukriati Chaira; Erizal Zaini; Trisfa Augia
Jurnal Sains Farmasi & Klinis Vol 3, No 1 (2016): J Sains Farm Klin 3(1), November 2016
Publisher : Fakultas Farmasi Universitas Andalas

Drug Management at health centers need to be well, because exellent drugs management will ensure the continuity of availability and affordability of drugs that are efficient, effective and rational. This study aims to determine drugs management at seven community health centers in Pariaman, based indicators of drugs management stipulated by Ministry Health of Republic Indonesia. This research is descriptive-evaluative, with quantitative and qualitative methods, using retrospective data in 2013 and 2014. The results showed that suitability of drug provided by DOEN 64.70%-73.51%, accuracy of drug demand, 2:28%-24.47%, accuracy of drug distribution 4.66% -35.59%, percentage of drugs that are not prescribed, 5:00%-23.49%, percentage of prescribing generic drugs 97.27% -100%, percentage differences in recording of stock card with amount of physical drugs, 0.00%-13.13%, it can be concluded that drugs management at health centers in Pariaman is not good, because it is not accordance with established standards.

Peningkatan Laju Disolusi Dispersi Padat Amorf Genistein dengan PVP K-30 Erizal Zaini; Vike Zulia Putri; Maria Dona Octavia; Friardi Ismed
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

Amorphous solid dispersions of a poorly water-soluble drug genistein in PVP K-30 were prepared by solvent co-evaporation technique using organic solvent methanol. Solid dispersions system was prepared with several variations of drug to polymer 2:1, 1:1 dan 1:2 w/w. Solid state properties of solid dispersion system were evaluated by powder X-ray diffraction, Fourier transform infrared spectroscopy, and differential scanning calorimetry, and microscopic SEM. Dissolution rate profile were conducted in distilled water medium by using dissolution tester apparatus type II USP. Base on X-ray diffractometry analysis, differential scanning calorimetry and microscopic SEM, crystalline phase of genistein decreased in crystallinity index and formation of amophous state. Dissolution rate profile showed that genistein in amorphous solid dispersion had a faster dissolution rate in comparison to intact genistein. This study proved that preparation of solid dispersion of genistein in PVP K-30 is an effective approach to improve dissolution rate of genistein.

Studi Sistem Dispersi Padat Klaritromisin – Eudragit L100 Yuska Noviyanty; Elfi Sahlan Ben; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

Solid dispersion made with the weight ratio (b/b) using the dissolving method. DTA analysis of the solid dispersion obtained in Eudragit L 100 affects the position and sharpness of the peak. X-ray diffraction analysis showed that of clarithromycin - Eudragit L 100 is in amorphous form and did not produce a new crystalline phase. SEM analysis showed that crystalline of Eudragit L 100 is smaller (amorphous) and stick to the surface of the clarithromycin crystal. IR spectrophotometer analysis showed that there is no chemical interaction between clarithromycin and Eudragit L 100. Clarithromycin assay was done by HPLC method, using mobile phase methanol and 0.067 M KH2PO4 (13:7) plus fospat acid pH 4.0. The dissolution profile by the time of 60 minutes are clarithromycin 45.73%, CF (1:1) 49.86%, DP (1:1) 51.53%, DP (2:1) 55.87% and DP (1:2) 58.97% respectively. Solid dispersion 1:2 (w/w) have an increased dissolution rate compared to clarithromycin.

Karakterisasi Fisikokimia Sistem Biner Siprofloksasin HCl – PEG 4000 Resva Meinisasti; Auzal Halim; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

"Physicochemical Characterization of Binary Systems Ciprofloxacin HCl - PEG 4000" has been reseach. This study aimed to characterize ciprofloxacin HCl formula that was developed to 9, with a comparison between ciprofloxacin - PEG 4000 following formula I (1: 9), formula II (2: 8), formula III (3: 7), formula IV (4: 6), formula V (5: 5), formula VI (6: 4), formula VII (7: 3), formula VIII (8: 2) and formula IX (9: 1). Binary system made by the manufacture of solid dispersion by melting method. The results of the binary System were characterized by analysis Differential Thermal Analysis (DTA), X-ray diffraction, IR spectrophotometry, and Scanning Electron Microscope (SEM). The results of this analysis have results of the binary solid dispersion systems a good formula this VII.

Peningkatan Laju Disolusi Ketoprofen Dengan Teknik Co-Grinding Menggunakan Polimer Hydroxypropyl Methylcellulose E6 Najmi Hilaliyati; Elfi Sahlan Ben; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

Improvement of the dissolution rate of ketoprofen as a model for a poorly water-soluble drug by solid state co-grinding technique with hydrophilic polymer hydroxypropyl methylcellulose E6 (HPMC) using mortar grinder apparatus have been investigated. Three different formulations prepared with varying drug : carrier ratio 1:2, 1:1, and 2:1 (w/w). Physical mixture prepared with ratio 1:1 (w/w). X-ray diffraction showed decrease of peak intensity of ketoprofen. DSC analysis showed decrease of melting point of ketoprofen. FTIR analysis showed no chemical interaction between drug and polymer. In this investigation, it was found that solubility tended to increase with increase in the amount of polymer used. Solid dispersion ratio 1:2 showed the highest solubility (6,5 fold). However, unlike the solubility results, the dissolution rate increased with decreases in polymer concentration due to thick diffusion layer formation of the polymer. Solid dispersion ratio 2:1 showed the highest dissolution (2,1 fold).

Persepsi, Pengetahuan, dan Sikap tentang Obat pada Siswa Sekolah Menengah Atas (SMA) di Kota Pariaman, Sumatera Barat Syofyan Syofyan; Habibie Deswilyaz Ghiffari; Erizal Zaini
Jurnal Sains Farmasi & Klinis Vol 4, No 1 (2017): J Sains Farm Klin 4(1), November 2017
Publisher : Fakultas Farmasi Universitas Andalas

The irrational use of drug and drug abuse are some of the impacts of low public knowledge about medicine, including in high school students. The purpose of this study was to assess perceptions, knowledge and attitudes about medicine among senior high school students in Pariaman City, West Sumatera. The research was conducted by descriptive and analytical method with cross-sectional by using questionnaire instrument. Data were analyzed using univariate and bivariate analysis. The results showed that students’ perception on medicine was categorized as high (95.5%), student attitude was positive (60.3%) but had less knowledge (74.8%). Students living in the city had higher knowledge than those living in the village. There was a significant correlation between perception and attitude (P <0.05), however, there was no correlation between knowledge and perception level (P> 0.05) and attitude (P> 0.05). Low perceptions and knowledge can encourage students to do more fatal errors such as medications or irrational drug use. Efforts such as education about medication in schools are very important steps to improve students’ knowledge about medicine.

Peningkatan Laju Disolusi Piperine dengan Pembentukan Multikomponen Kristal Menggunakan Asam Nikotinat Yeni Novita Sari; Erizal Zaini; Friardi Ismed
Jurnal Sains Farmasi & Klinis Vol 6, No 2 (2019): J Sains Farm Klin 6(2), Agustus 2019
Publisher : Fakultas Farmasi Universitas Andalas

Tujuan penelitian ini adalah untuk meningkatkan laju disolusi piperin dengan pembentukan multikomponen kristal piperin dan asam nikotinat (1:1) dengan metode pelarutan menggunakan pelarut etanol. Multikomponen kristal dikarakterisasi sifat padatannya dengan Difraksi sinar-X, analisa termal Differential Scaning Calorimetry (DSC), spektroskopi FT-IR, analisa mikroskopik Scanning Electron Microscopy (SEM), uji kelarutan dan profil laju disolusi menggunakan Aparatus USP 2. Dari penelitian serbuk multikomponen kristal piperin-asam nikotinat diperoleh hasil pola difraksi sinar-X menunjukkan puncak difraksi yang baru, analisa termal termogram DSC menunjukkan puncak endotermik pada 126,117 ºC, spektrum FTIR terdapat bilangan gelombang 3349,94 cm-1, analisa mikroskopik SEM menunjukkan sudah terbentuk agregat, uji kelarutan menunjukkan peningkatan 1,5 kali lipat dibandingkan piperin murni, profil laju disolusi piperin menunjukkan peningkatan secara signifikan dibandingkan piperin murni yaitu sekitar 2,5 kali lipat. Secara umum preparasi multikomponen kristal piperin-asam nikotinat dapat meningkatkan laju disolusi piperin

Pembentukan Sistem Dispersi Padat Amorf Azitromisin Dihidrat dengan Hikroksipropil Metilselulosa (HPMC) Erizal Zaini; Netty Novitasari; Maria Dona Octavia
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

The aim of present study is to develop solid dispersion system of azithromycin dihydrate with hydroxypropyl methylcellulose E5 LV (HPMC) for improving the dissolution rate of azithromycin dihydrate. Amorphous solid dispersions were prepared by solvent method at 1:1; 1:2 and 2:1 (w/w) drug to polymer ratios. Solid state properties of amorphous solid dispersion were evaluated by X-ray powder diffraction (XRPD), scanning electron microscopy and spectroscopy FT-IR. Furthermore, the dissolution rate profile was investigated by type II USP dissolution apparatus. Based on X-ray powder diffractometry analysis, azithromycin dihydrate was transformed partially from the crystalline phase to the amorphous state as confirmed by significant reduction of the crystalline peaks intensity. FT-IR spectroscopy analysis revealed the absence of chemical interaction between azithromycin dihydrate and HPMC. The dissolution rate of azithromycin dihydrate from amorphous solid dispersion was substantially higher than azithromycin dihydrate intact and its physical mixture. The dissolution rate of azithromycin dihydrate increased with an increasing drug to polymer ratio.

Co-Authors -, Salman Adhitya Jessica Agusri Boestari Akmal Djamaan Amri Bakhtiar Annisa Agustina Asiska Permata Dewi Asiska Permata Dewi Asiska Permatadewi Auzal Halim Auzal Halim Ben, Elfi Sahlan Deni Anggraini Deni Noviza Dhea Sultana Lutfiyah Dwi Setyawan Ellyza Nasrul Elpa Giovana Zola Elvi Rahma Yulisman Elvita Sari Fauzi Saputra Fifi Harmely Friardi Ismed Gaesari, Sherly Rahmah Habibie Deswilyaz Ghiffari Hansen Nasif Helen Sonita Helen Sonita Henny Lucida Hulwa Salsabila Ima Kurniati Irna Kurniati Kiki Rizky Wirza Kurniati, Irna Lili Fitriani Mai Efdi Maria Dona Octavia Melisa Melisa Melzi Octaviani Muhammad Taher Muthia Fadhila Najmi Hilaliyati Netty Novitasari Nova Syafni Novica Sari Rahmadevi Rahmi Nofita Rahmi Yosmar Resva Meinisasti, Resva Rifka Naura Rini Agustin Rini Agustin Rose Intan Perma Sari Rustini Rustini Rustini Rustini S, Agnes Saafrida Saafrida Salman - Salman - Salman Salman Salman Umar Salman Umar Salman Umar Sundani N. Soewandhi Sundani N. Soewandhi, Sundani N. Syofyan Syofyan SYUKRAN HAMDENI Syukriati Chaira Trisfa Augia Try Andy Sahputra Uswatul Hasanah Verlia Nisrina Putri Vike Zulia Putri Vina Oktavia Yeni Novita Sari Yeyet C. Sumirtapura Yufri Aldi Yuska Noviyanty Zahara Gayo Zulhadjri Zulhadjri

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