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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Higea Majalah Farmasetika Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian
Erizal Zaini
Departemen Farmasetik, Fakultas Farmasi, Universitas Andalas, Padang 25163
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Medical Sains : Jurnal Ilmiah Kefarmasian

 1 
ISOLASI DAN KARAKTERISASI SERBUK ENZIM BROMELIN DARI BATANG NANAS (ANANAS COMOSUS (L.) MERR).: ISOLATION AND CHARACTERIZATION OF BROMELIN ENZYME POWDER FROM Pineapple Stem (ANANAS COMOSUS (L.) MERR). Rose Intan Perma Sari; Salman; Erizal Zaini
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.432

Abstract

Bromelin merupakan unsur pokok dari nanas yang penting dan berguna dalam bidang farmasi dan makanan, untuk mendapatkan enzim bromelin dari buah nanas diperlukan proses isolasi enzim bromelin. Tujuan dari penelitan ini adalah untuk mengisolasi dan mengkarakterisasi serbuk enzim bromelin dari batang nanas (Ananas Comosus (L.) Merr). Isolasi enzim bromelin dari batang nanas telah dilakukan dengan menggunakan pelarut dapar fosfat pH 7.0 disentrifugasi pada 3.500 rpm selama 15 menit. Serbuk enzim bromelin diperoleh dengan menggunakan metoda freeze drying dan didapat persentase randemen sebesar 2,032 %. Karakterisasi dari serbuk enzim bromelin terdiri dari pengukuran kosentrasi protein, penentuan aktivitas enzim dan aktivitas spesifik enzim. Pengukuran konsentrasi protein menggunakan metoda Biuret memberikan hasil konsentrasi sebesar 1,66±0,003 mg/ml. Penetuan aktivitas enzim menggunakan metoda Murachi memberikan hasil aktivitas enzim sebesar 43,09±0,01 U/ml dan aktivitas spesifik enzim sebesar 26,02±0,003 U/mg.
PREPARATION AND CHARACTERIZATION PHISICOCHEMICAL PROPERTIES OF MULTI COMPONENT KETOPROFEN WITH CO-FORMER GLUTAMINE Helen Sonita; Erizal Zaini; Salman Umar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.799

Abstract

Ketoprofen is a non-steroidal anti-inflammatory compound (NSAID) which has low solubility in water. This study aimed to increase the dissolution rate of ketoprofen by forming multicomponent ketoprofen-glutamine in ratios of 1:1, 1:2, and 2:1 using the solid-state grinding method. The samples were characterized using Powder X-Ray Diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) Spectroscopy, Scanning Electron Microscope (SEM), solubility, dissolution rate, and stability tests. These results indicated the formation of a eutectic mixture of ketoprofen-glutamine. From the study of the ketoprofen–glutamine eutectic mixture, the eutectic point at a ratio of 1:1 was obtained at 95.51°C. The PXRD spectra did not show new crystal habits; the solubility test of the eutectic mixture of ketoprofen-glutamine showed increases of 2.450, 2.518, and 2.374 times, respectively. The eutectic mixture of ketoprofen–glutamine had rod-like crystal particles that formed and aggregated. The samples showed an increased dissolution rate of ketoprofen. The stability test showed that ketoprofen-glutamine was stable during storage at 75% relative humidity (RH) and 40 °C for 6 months; there was only a decrease in intensity, as seen from the PXRD spectrum. Keywords: eutectic mixture, ketoprofen, glutamine, solubility, dissolution rate, stability
Co-Authors -, Salman Adhitya Jessica Agusri Boestari Akmal Djamaan Amri Bakhtiar Annisa Agustina Asiska Permata Dewi Asiska Permata Dewi Asiska Permatadewi Auzal Halim Auzal Halim Ben, Elfi Sahlan Deni Anggraini Deni Noviza Dhea Sultana Lutfiyah Dwi Setyawan Ellyza Nasrul Elpa Giovana Zola Elvi Rahma Yulisman Elvita Sari Fauzi Saputra Fifi Harmely Friardi Ismed Gaesari, Sherly Rahmah Habibie Deswilyaz Ghiffari Hansen Nasif Helen Sonita Helen Sonita Henny Lucida Hulwa Salsabila Ima Kurniati Irna Kurniati Kiki Rizky Wirza Kurniati, Irna Lili Fitriani Mai Efdi Maria Dona Octavia Melisa Melisa Melzi Octaviani Muhammad Taher Muthia Fadhila Najmi Hilaliyati Netty Novitasari Nova Syafni Novica Sari Rahmadevi Rahmi Nofita Rahmi Yosmar Resva Meinisasti, Resva Rifka Naura Rini Agustin Rini Agustin Rose Intan Perma Sari Rustini Rustini Rustini Rustini S, Agnes Saafrida Saafrida Salman - Salman - Salman Salman Salman Umar Salman Umar Salman Umar Sundani N. Soewandhi Sundani N. Soewandhi, Sundani N. Syofyan Syofyan SYUKRAN HAMDENI Syukriati Chaira Trisfa Augia Try Andy Sahputra Uswatul Hasanah Verlia Nisrina Putri Vike Zulia Putri Vina Oktavia Yeni Novita Sari Yeyet C. Sumirtapura Yufri Aldi Yuska Noviyanty Zahara Gayo Zulhadjri Zulhadjri