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Journal : Lansau: Jurnal Ilmu Kefarmasian

Aktivitas Antihiperglikemik Ekstrak Daun Gedi Merah (Abelmoschus manihot L.Medik) pada Tikus Model Diabetes Melitus Tipe II: Antihyperglycemic activity of Red Gedi Leaf Extract (Abelmoschus manihot L.Medik) in Type II Diabetes Mellitus Model Rats Nuralifah; Parawansah; La Ode Muhammad Fitrawan; Irvan Anwar; Alya Zuhriyah
Lansau: Jurnal Ilmu Kefarmasian Vol. 1 No. 1 (2023): Lansau: Edisi April 2023
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/lansau.v1i1.5

Abstract

Type II diabetes mellitus is a metabolic disorder characterized by increased blood glucose levels due to damage to pancreatic β cells which causes reduced insulin production or abnormal insulin action. The leaves of Abelmoschus manihot L.Medik as an antidiabetic have been used empirically by the community. This study aims to determine the activity of the ethanol extract of Abelmoschus manihot L.Medik leaves as an antihyperglycemic agent in male rats fed a high-fat diet and experiencing type 2 DM induced by streptozotocin. The test animals were divided into six groups: the normal control group (KN) without treatment; the negative control group (K-), which was treated with 0.5% NaCMC, the positive control group (K+), which was treated with metformin 9 mg and the test group of extracts. With doses varying from 75 mg/kg, 150 mg/kg, and 300 mg/kg, rats were first given a high-fat diet, then induced by streptozotocin at a 30 mg/kg dose extract was given for seven days. The results of the phytochemical screening showed that the ethanol extract of red gedi leaves contained alkaloids, flavonoids, tannins, saponins, and steroids. The measurement results showed that administering ethanol extract of red gedi leaves (Abelmoschus manihot L.Medik) doses of 75 mg/kg, 150 mg/kg, and 300 mg/kg affected reducing blood glucose levels in male rats of the Wistar strain type II diabetes mellitus model. Significant based on the One-way ANOVA test and the Least Significance Difference (LSD) post hoc test.
Co-Authors Akib, Nurlliyin Alya Zuhriyah Amirudin Eso Andi Noor Kholidha Andi Noor Kholidha Andi Noor Kholidha Syarifin Antrie, Geong Arba, Muhammad Arfan Arfan Ariani, Eno Retno Arismawati, A Armadany, Fery Indradewi Asriulah Jabar Damu, Rusliati Eso, Amiruddin Fadhliyah Malik Feri Indradewi Ferry Sandra Fery Indradewi Armadani Fery Indradewi Armadany Fitrawan, L.O.M. Fitrawan, La Ode Muhammad Fitriani Sonaru Gemini Alam Hasniana Nur Hasniar, Wa Ode Helma Yanda Serah I Putu Sudayasa I Putu Sudayasa Iko, Ria Agus Indah Amalia Lestari Indah Purnamasari Irma Irvan Anwar Jabbar, Asriullah Jamsir, Asmaidah Karmilah Kasmawati, Henny La Ode Muhammad Fitrawan Loly Subhiaty Idrus Mardiani, Siti Mesi Leorita, Mesi Mesrawati Trisetya Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Ilyas Yusuf Mulyawati, Sufiah Asri Munasari, Dian Murniaty Mursyidah Apriatin Muslihin, Sari Melyana Ni Nyoman Fitri Astari Ningsih, Warda Ayu Nining Yulianti Nur illiyyin Akib Nurrokhmadhani, Wa Ode Sitti Nurul Febrina Rahmawati Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah, Parawansah Parawansah, P Parawansah, P Pratiwi, Aulif Puteri Febriyanthi Rachman Rahmat Ramadhan Rahmawati Rahmawati Rifa’atul Mahmudah Rini, Risky Sesa Rosdiana Natzir Sabarudin Sabarudin Sabarudin, S Satriana Nasrun Septiyana, Wanda Sitti Fazrianti Saputri Sofianti Tarta Sri oktaviani Sudiman, Aswan Sunandar Ihsan Sunandar Ihsan, Sunandar Syasna, Annisa Tomy Nurtamin Ulan Dwi Shintia Wa Ode Arlina Misnaeni Wa Ode Nurmayanti Wa Ode Siti Rahayu Fathanah Wa Ode Sitti Asfiah Udu, Wa Ode Sitti Asfiah Wa Ode Tika Ertia Wahid Wahyuni Wahyuni Yulfa Yulfa