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Ikhram Hardi S
Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia
Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Indian Journal of Forensic Medicine

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The Effect of Black Cumin (Nigella sativa) Oil Supplementation on Hematotoxicity Induced by Benzene in Gasoline Vapors from Gas Stations in Male Wistar Rats Ikhram Hardi S; Merryana Adriani; Tri Martiana
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15810

Abstract

This study aimed to prove the effect of black cumin oil supplementation through analysis of levels of CYP2E1, MDA, GSH, and hematological profiles in experimental animals, Wistar rats, which were exposed to benzene in gasoline vapors from gas stations. Sixty-four experimental Wistar rats were divided into eight groups with eight rats each, two control groups (C1 and C2), and six experimental groups (T1, T2, T3, T4, T5, and T6). Blood samples of experimental rats were taken through intracardiac with ketamine-xylazineacepromazine anesthesia on day 15 for group C1, C2, T1, T3, and T5; and day 29 for group T2, T4, and T6. The ELISA method measured the levels of CYP2E1, GSH, and MDA in this study, while the hematological profile used a hematology analyzer. This study indicates that benzene in gasoline vapors exposure caused significant hematotoxicity (P <0.05). Supplementation of black cumin seed oil at a dose of 2.5 ml/kg, 5 ml/kg, and 10 ml/kg, all of which have the potential to provide a protective effect against the hematotoxicity of benzene in gasoline vapors through increased internal antioxidants (GSH). The GSH can play a role in the mechanism of vapor metabolism of substances in gasoline vapors in the body through decreased CYP2E1 levels and decreased MDA levels. Further research is still needed with a more extended treatment duration to ascertain the chronic effects of benzene hematotoxicity on the genomic pathway to assess black cumin’s role, whether in the form of oil, powder, or other forms of extraction.
Co-Authors Abd. Gafur Abd. Gafur Alfina Baharuddin Amelia, Andi Rizki Amelinda Amir Amir, Amelinda Anah Silmih Bakri Andi Husnul Khatima Andi Nurlida Andi Nurlinda Andi Rina Apriyanti Rizal Anugrah Awaliah Julianti Arni Rizqiani Rusydi Aulia Rahman Ayu Puspitasari Bakri, Anah Silmih Dhea Puspita Dini Dwi Pratiwi Chaerul Ella Andayanie Githa, Zargitha Cahyani Moeya Haeruddin Haeruddin Haeruddin Hamzah, Wardiah Haq, Firka Wafiq Nurul Hasan, Chaeruddin Husnul Hotimah Husnul Hotimah, Husnul I Gusti Wayan Murjana Yasa Idris, Fairus Prihatin Iriyani Malik Malik, Iriyani Mansur Sididi Masriadi Merryana Adriani Merryana Adriani Muhammad Ikhtiar Muhammad Khidri Alwi Muhammad Khidri Alwi Namira Ilham Nur Ulmy Mahmud Nurbaety Nurwahyuni Syahrir Pratiwi, Dini Dwi Putri Tasmila Resky Rahman Rahman Rahmatia Rahmatia Sandra Triani Sandra Triani Septiyanti Septiyanti, Septiyanti Sitti Halijah Sitti Patimah Suharni A. Fachrin Suharni Suharni Sumiaty syahrir, Nurwahyuni Tri Martiana Wildani Wildani Yuliati Yuliati Yuliati Yuliati Yuliaty Yusriani, Yusriani Zargitha Cahyani Moeya