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ISSN : - EISSN : 25408844 DOI : -

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Medicine & Pharmacology

JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.

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Search results for , issue "Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )" : 16 Documents clear

THE EFFECT OF BREASTFEEDING EDUCATION AMONG POSTPARTUM MOTHERS ON EXCLUSIVE BREASTFEEDING PRACTICE ONE MONTH AFTER DELIVERY Laurentius Juan Wicaksono; Dimas Tri Anantyo; Julian Dewantiningrum; Bambang Hariyana
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: Exclusive breastfeeding is a standart of care for newborn. In 2017 within area of Semarang City, only 19,5% women who practiced exclusive breastfeeding .One of the problems was low level of mother’s knowledge because lack of breastfeeding education especially by the health services institutions. The aim of the study is to asses the effect of breastfeeding education among postpartum mothers on exclusive breastfeeding practice in one month after delivery. Method: A quasi experimental study design was conducted among postpartum mother in purposively selected health institutions of Semarang city. All eligible women were placed into intervention (n=25) and control (n=25) group. The intervention group received standart education with educational media and control group received standart education only which lasts for 15 minutes. Data were collected through interviewer-administered questionnaire at one month after education session. Results: The number of mothers who practiced exclusive breastfeeding for a month was greater in intervention group than the control group (p=0,025). The level of knowledge also greater in intervention group (p=0,016). Also, there were no significant relationship between age, working status, maternal parity and exclusive breastfeeding while there was significant relationship between maternal education and exclusive breastfeeding practice. Conclusion: Breastfeeding education with educational media increases the mother’s knowledge about exclusve breastfeeding and practice of exlusive breastfeeding up to 1 month.

CLINICAL AND HISTOPATHOLOGICAL CHARACTERISTICS OF PRIMARY BRAIN TUMOR DISEASE IN RSUP DR. KARIADI SEMARANG Madani Hastutyosunu; Trianggoro Budisulistyo; Arinta Puspita Wati
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Introduction: Primary brain tumour is one of the non-communicable diseases that ranks 17th of all types of cancer in the world with an estimated 256,000 new cases each year. The incidence in North America, Europe and Australia is quite high with an estimated 4-8 new cases per 100,000 population per year. The incidence in continental countries of Asia and Africa is less compared to developed countries. The low incidence and mortality of brain tumours in the continents of Asia and Africa, especially in Indonesia, is thought to be due to the low reports of brain tumour disease from some of these countries, so as to increase knowledge and management of brain tumour plenary services in Indonesia, accurate hospital clinical data is needed. Objective: This study aims to look at the frequency of events, symptoms and clinical signs, histopathological characteristics, the stage at diagnosis, and compare the incidence of primary brain tumours in men and women. Methods: This study used a descriptive observational study design that uses data on primary brain tumour patients in the period of January 2017 - December 2018. Data collected includes clinical symptoms and signs, histopathological characteristics, and tumour tissue characteristics. Results: From 72 patients with primary brain tumour, only 36 (50%) of data can be used as samples due to the completeness of the medical record. The most common clinical symptoms and signs are headache, followed by limb disorders, and visual impairment. The most common histopathological features are Astrocytic tumour with a ratio of 17: 5 for men and women respectively. Conclusion: Primary brain tumours in RSUP Dr. Kariadi Semarang is often found with symptoms of headache followed by limb disorders and visual impairment, with a type of Astrocytic tumour that is more commonly found in men.

ANTIMICROBIAL EFFECT OF ARROWROOT (Maranta arundinacea L.) METHANOLIC EXTRACT AGAINST Staphylococcus aureus BACTERIAL GROWTH Syahputra, Muhammad Ghaza; Antari, Arlita Leniseptaria; Winarto, Winarto; Lestari, Endang Sri
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Introduction: Staphylococcus aureus is a spherical gram-positive bacterium that forms clusters and is frequently resistant to antibiotics. Methicillin-Resistant Staphylococcus aureus (MRSA) is a strain of S. aureus that is resistant to beta-lactam and cephalosporin groups of antibiotics, it is one of the biggest problems in resistant bacteria. Plants that have flavonoids in their extract can inhibit the growth of bacteria by impairing their cytoplasmic membrane. Arrowroot is an example of plants that have flavonoids in their extracts. Objectives: This research aims to determine the antimicrobial effect of arrowroot (Maranta arundinacea L.) methanolic extract against the growth of Staphylococcus aureus in vitro. Methods: This is true experimental research with a post-test control group design with two control groups and eight experimental groups. The sample of this research utilizes the MRSA strain of S. aureus received from the Microbiology Laboratory of Diponegoro University Faculty of Medicine that was eligible with the inclusion criteria. The research was conducted by using arrowroot extract concentrations 6.5%, 12.5%, 25%, 50%, and 100% to determine the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and inhibitory zone diameter. Results: MIC and MBC of arrowroot methanolic extract against MRSA is 100%. The arrowroot methanolic extract to have yielded an inhibitory zone diameter is 100% with a mean inhibitory zone diameter of 15.5mm. Conclusion: Arrowroot methanolic extract can inhibit the bacterial growth of MRSAKeywords: Staphylococcus aureus, growth, M. arundinacea L. methanolic extract

COMPARISON OF THE EFFECTIVENESS OF CURCUMA DOMESTICA EXTRACT AND CURCUMA XANTHORRIZA EXTRACT AGAINST LIVER FUNCTION AND HEPATIC CELL INFLAMMATION ON STREPTOZOTOCIN-INDUCED DIABETES MELLITUS MICE Amira Naufal; Alfin Ihza Trimahendra; Astika Widy Utomo; Vega Karlowee; Awal Prasetyo; Mochamad Ali Sobirin
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: Diabetes mellitus can cause complications including liver damage, which has an impact on increasing levels of SGOT and SGPT in the blood, as well as inflamation and hepatic steatosis. Turmeric (Curcuma domestica) and java turmeric (Curcuma xanthorizza) are known to have high levels of curcumin and xanthorizzol as an antioxidant and proven to improve liver function. Antioxidant therapy in patients with NAFLD is known to improve liver function and histopathological features. The effects of turmeric and java turmeric extract on liver function in streptozotocin-induced diabetes mellitus mice are still unknown. Objective: Comparing effects of administered turmeric and java turmeric extract on liver function and histopathologic features of streptozotocin-induced diabetes mellitus mice. Method: Research design Post Test Only Control Group Design are used. Male swiss mice around 25-30 gram are used. Streptozotocin-induced diabetes mellitus mice with a total samples (n = 20) divided into 4 groups, Control+PBS, Control+STZ, STZ+Turmeric, and STZ+Java Turmeric (an = 5). Blood glucose, weight, SGOT, SGPT levels and histopathologic features including percentage of inflamation and hepatic steatosis were examined at day 21. All the research data were analyzed using statistics program. Result: Turmeric and java turmeric extract cannot significantly reduce blood glucose level. Administration of java turmeric extract significantly reduce SGPT level against control+STZ group (84,12±17,53 vs. 36,3±27,4 u/L, p=0,018). Administration of turmeric extract significantly reduce hepatic cell inflamation against control+STZ group (30(26-68) vs. 20(15-30)%, p=0,035). Conclusion: Each turmeric and java turmeric extract can improve liver fuction and decreasing hepatic cell inflamation on streptozotocin-induced diabetes mellitus mice, but may not mediated by decreasing blood glucose level.

THE EFFECT OF PLYOMETRICS TRAINING ON EXPLOSIVE POWER OF MEDICAL STUDENTS IN DIPONEGORO UNIVERSITY Pramatama Andhika Sunarso Pandoyo; Darmawati Ayu Indraswari; Marijo Marijo; Yuriz Bakhtiar
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Introduction : Explosive power are the combination maximum strength and maximum velocity. High value of muscle strength and velocity can lead to good measurement of explosive power. Plyometrics training known as an exercise that can increased explosive power. This exercise is really popular among athletes and has proven to increase their explosive power. However, there’s still no further study that measured explosive power on medical students after given plyometrics training treatment. Methods : Quasi experimental study of plyometrics training has done for 6 weeks to medical students Diponegoro University. 28 subjects was divide into 2 groups : plyometrics training (as treatment group) and control group (as non-treatment group). Vertical jump test score was measurement in pre-test, middle-test, and post-test. The explosive power measured by vertical jump test. The results were analyzed by SPSS software. Results : The explosive power improved among subjects in plyometrics treatment group. During the plyometrics treatment, vertical jump was singnificantly increase during treatment in pre-test to mid-test (35.93 cm to 49,21 cm ; P : <0.001) and mid-test to post-test measurement (49.21 cm to 54.21 cm ; P : <0.001). Vertical jump score significantly increase in plyometrics group compare to control group ; on middle-test (<0.001 vs 0.344 ; P 0.019) and post-test (<0.001 vs 729 ; P 0.001) measurement respectively. Conclusions : Plyometrics training improved lower limb explosive power in male medical students of Diponegoro University. This is marked by significantly increase among subjects in plyometrics treatment group.Keywords: Plyometrics Training, Explosive Power, Vertical Jump Test

KEPATUHAN CUCI TANGAN PETUGAS RAWAT INAP DI RUMAH SAKIT NASIONAL DIPONEGORO SEMARANG Rahma Athifah Amelia; Winarto Winarto; Purnomo Hadi; Endang Sri Lestari
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Latar belakang : Cuci tangan merupakan tindakan efektif untuk mencegah transmisi patogen dari petugas medis ke pasien maupun sebaliknya, untuk pencegahan infeksi nosokomial, namun tidak fokus pada kegiatan cuci tangannya saja, tetapi juga tingkat kepatuhan pelaksanaan cuci tangan itu sendiri. Perlu dilakukan penelitian tentang tingkat kepatuhan pelaksanaan cuci tangan tersebut. Tujuan : Mengetahui kepatuhan cuci tangan petugas rawat inap Rumah Sakit Nasional Diponegoro Semarang. Metode : Desain penelitian ini adalah cross sectional. Sampel dalam penelitian ini adalah petugas rawat inap di ruang Lavender, Chrysant, Gladiol, dan ICU. Penelitian dilakukan selama periode Mei-Juni 2018. Alat yang digunakan adalah lembar observasi indikasi 5 momen WHO dan lembar kuesioner menilai karakteristik sampel. Data yang didapatkan dianalisa menggunakan analisa univariat. Hasil : Dari 441 indikasi 5 momen cuci tangan didapatkan kepatuhan cuci tangan sebanyak 221 (50.1%). Ruang dengan kepatuhan tertinggi adalah Lavender (84.1%) diikuti ruang ICU (60.9%), ruang Chrysant (42.9%), dan ruang Galdiol (36.8%). Profesi dengan kepatuhan tertinggi adalah dokter (60%). Pendidikan terakhir terbanyak adalah D3 (40.5%). Sebanyak 72.6% petugas rawat inap sudah bekerja selama 1-4 tahun. Beberapa faktor potensial yang berpengaruh terhadap angka kepatuhan cuci tangan adalah pengetahuan, persepsi tentang pentingnya cuci tangan, keuntungan cuci tangan, hambatan cuci tangan, motivasi cuci tangan dan sikap. Simpulan : Kepatuhan cuci tangan petugas rawat inap Rumah sakit Nasional Diponegoro Semarang adalah 50.1%.

THE EFFECT OF JENGKOL SEED (Archidendron pauciflorum) EXTRACT TO PLASMA MDA LEVEL DUE TO DEEP SECOND DEGREE BURN WOUND IN SPRAGUE DAWLEY RATS Kurniati, Steffi; Batubara, Lusiana; Wikanta, Edmond Rukmana; Johan, Andrew
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: During inflammatory phase of the burn healing process, the number of plasma MDA levels tend to increase, which may cause damage towards cells and thus delay the resolution of burn wounds. Some research has been done in order to find alternative treatment for burn wound, including the application of antioxidant. Jengkol contains many antioxidant compounds which are expected to reduce plasma MDA levels, so it can accelerate the healing of burn wound. Aim: To prove that administration of jengkol extract can reduce plasma MDA level in Sprague dawley rats which were been given burn wound. Method: This experiment was using pre and post-test control group design, with 20 Sprague dawley rats as samples. All of the samples were given deep second degree burn wound which were then divided equally into 2 groups, treatment group (given jengkol extract 500 mg/KgBW) and control group (not given anything). Plasma MDA levels were then analyzed by using TBARS method. Data was analyzed using paired T-test, Wilcoxon, Mann-Whitney, and independence T-test. Result: There is no significant difference between the mean of plasma MDA levels in pre and post-test of either control group (p=0.771) or in the treatment group (p=1.00). Using Mann-Whitney test, there isn’t any significant difference in the pre-test between control and treatment group (p=0.677) or in the post-test between control and treatment group (p=0.916) by using independence T-test. Conclusion: Jengkol extract cannot reduce plasma MDA levels of Sprague dawley rats which were given burn wound.

THE INFLUENCE OF BEETROOT (Beta vulgaris) ON SPERMATOZOA VITALITY OF WISTAR RATS EXPOSED TO MOSQUITO COILS Bharadaksa, Mohammad Arya Lingga; Ariani, Mahayu Dewi; Dewi, Puspita Kusuma; Nugroho, Trilaksana
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: Spermatozoa vitality is one of the sperm analysis test. Application mosquito coil repellentgenerates free radical enhancement. Free radical contribute to external factor thatinfluence the quality of spermatozoa vitality. Beetroot(Beta vulgaris) contain a considerably high amount of antioxidant. It reduce free radical in the body and improve quality of spermatozoa vitality. Aim: To find out and analyze the effect of beetroot (Beta vulgaris) on the spermatozoa vitality of male wistar rats exposed to mosquito coils. Methods: This research uses experimental methods, with a post-test only control group design. The research sample was selected using a simple random sampling technique28 male wistar rats met the inclusion and exclusion criteria, then divided into 4 treatment groups K (-), K (+), P1 and P2.Data obtained after 56 days of treatment with 7 days of adaptation before treatment, the data will be tested for normality with Shapiro-Wilk then proceed one way ANOVA if the data distribution is normal. Results: Shapiro-Wilk test showed no significant differences between groups K (-), K (+), P1 and P2 (p> 0.05). One way ANOVA test on sperm vitality analysis showed a significant difference between groups. Post-Hoc test showed sperm vitality on K (+) there was significant difference compared to K (-) (p <0.001), K (+) no significant difference compared to P1 (p = 0.244) and K (+) there was significant difference compared to P2 (p = 0.001). Conclusion: Giving beetroot juice with the right dose has a significant effect on the spermatozoa vitality of male wistar rats exposed to the smoke of mosquito coils.

THE EFFECT OF MAT PILATES IN LUMBAR FLEXIBILITY OF OVERWEIGHT AND OBESE CHILDREN Graciela Eunike Hartono; Tanti Ajoe Koesoema; Rahmi Isma AP; Dimas Tri Anantyo
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background : Overweight and obesity are the conditions where lumbar have to bear more load, and it will decrease its flexibility. Decrease of lumbar flexibility will affect the range of motion. Based on some literatures, mat pilates will increase the ability on lumbar flexibility, however there is no evidence effect of mat pilates in children, especially overweight and obese children. Aim : To know the effect of mat pilates on lumbar flexibility of overweight and obese children. Method :This study was pre experimental one group pre and post test design with 20 subjects based on inclusion dan exclusion criteria. Subjects did mat Pilates exercise for 12 times. Lumbar flexibility was measured by Modified Modified Schober Test for lumbal flexion and extension before intervention and after 4 weeks mat pilates exercise. Data analyzed by SPSS using Saphiro Wilk test as data’s nomalities test and Paired T test as hypothesis test. Result : The mean of MMST Flexion pre and post test after Mat Pilates have increased from 3,15±0,3118 cm to 7,63±0,4 cm. The mean of MMST extension pre and post test after Mat Pilates hav e increased from 1,415±0,21 cm to 3±0,236 cm. The means of a BMI Post test (24,89 ± 0,9 kg/m2) is higher than the mean of a BMI Pre test (24,86 ± 0,8 kg/m2).The significant result proves the effect of mat pilates in lumbar flexibility of overweight and obese children which measured by MMST Flexion and MMST Extension. The result of p value for MMST Flexion is p=0,00 and the result of p value for MMST Extension is p=0,00 which both of MMST flexion and Extension are significant or different. Conclusion : Mat pilates can increase the lumbar flexibility of overweight and obese children.Keyword: Mat Pilates, Lumbar Flexibility, overweight and obese children.

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DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 3 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

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