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All Journal Jurnal Penelitian Kesehatan THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Jurnal Kesehatan Prima Jurnal Ilmu dan Teknologi Kesehatan JURNAL PENELITIAN KESEHATAN Jurnal Analis Medika Biosains (JAMBS) JPP Jurnal Kesehatan Poltekkes Palembang Jurnal Ilmiah Tatengkorang Jurnal TEKNOKES
Christ Kartika Rahayuningsih
Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Jurnal TEKNOKES

 1 
Differences In Cadmium (Cd) Levels In The Blood of Active Smokers And Passive Smokers With Type 2 Diabetic In Puskesmas Kedungdoro Surabaya Christ Kartika Rahayuningsih; Devi Puspitasari; Ayu Puspitasari
Jurnal Teknokes Vol 15 No 2 (2022): June
Publisher : Jurusan Teknik Elektromedik, POLTEKKES KEMENKES Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/jteknokes.v15i2.198

Abstract

The degree of smoking habits in the urban community is still high, although carried out health promotion of harmful substances in cigarettes, one of which is cadmium (Cd). The dangers of cadmium in cigarette smoke causes harm to active and passive smokers. Increased exposure of cigarettes will lead to an increase in the burden of disease in groups at risk such as people with Diabetic Type 2 (DMT2). The purpose of this study was to determine the differences in levels of cadmium (Cd) in the blood of active smokers and passive smokers patients with DMT2 in Puskesmas Kedungdoro Surabaya. The type of this research is a comparative with cross-sectional study design conducted in the Toxicology Laboratory of the Department of Health Analyst and Research and Standardization Center of Industry in August 2020-May 2021. The independent variable in this study is active smokers and passive smokers patients with DMT2, and the dependent variable in this research is the content of cadmium (Cd) in the blood. Analysis of the levels of cadmium in the blood using Atomic Absorption Spectrophotometer by the method of acidifying carbon furnaces. The results showed range levels of cadmium in blood in 8 people suffer from Type 2 Diabetic as active smokers are 0.605-1.5535 µg/dL. While the range levels of cadmium in the blood of the 8 people who suffer from Type 2 Diabetic as passive smoking are 0.5648-2.7045 µg/dL. Based on the results of statistical tests using test Independent Sample T-Test, it can be concluded that there is no difference in the levels of cadmium (Cd) in active smokers and passive smokers patients with DMT2 in Puskesmas Kedungdoro Surabaya.
The Effectiveness Of Moringa Leaf Extract (Moringa oleifera) on Cadmium and LDL Cholesterol Levels in Blood as Indicators of Atherosclerosis in Cadmium (Cd) Induced White Rats (Rattus norvegicus) Vernanda Arsya Nabilla; Indah Lestari; Christ Kartika Rahayuningsih; Juliana Christyaningsih
Jurnal Teknokes Vol 15 No 3 (2022): September
Publisher : Jurusan Teknik Elektromedik, POLTEKKES KEMENKES Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/teknokes.v15i3.268

Abstract

Moringa leaves (Moringa oleifera) have chelating agent properties that act as natural antioxidants in binding heavy metals and free radical scavengers, with cadmium being one of the heavy metals free radicals having toxic effects on the body. Exposure to cadmium can reduce the activity of lipoprotein lipase enzymes (LPL) which function in the triglycerides and free fatty acids catabolism process, and can increase cholesterol and triglyceride levels in the blood. This study aims to determine the effectiveness of Moringa (Moringa oleifera) on Cadmium chloride-induced white rats (Rattus norvegicus) using an experimental research design with a quantitative analysis technique. This study uses the level of cadmium and LDL cholesterol for the dependent variable and the dose of Moringa leaf extract (Moringa oleifera) for its independent variable. The samples used are white rats (Rattus norvegicus) aged 8-12 weeks with a weight of 150-200 grams, along with blood drawn from the heart for the specimen. The researcher conducted the study at the Faculty of Veterinary Medicine, Airlangga University; Surabaya Health Laboratory Center; and Surabaya Bakti Analysis Laboratory from October 2021 to June 2022 using Atomic Absorption Spectrophotometry (AAS) and Chemical Analyzer BS-200. The results show that the average value of cadmium and LDL cholesterol levels in white rats in treatment group 1 are 0.605 g/dL and 8.25 mg/dL, group 2 are 0.075 g/dL & 18.5 mg/dL; and group 3 are 0.08125 g/dL and 12 mg/dL. Based on the statistical analysis of the One-Way ANOVA test, the sig. p-value is > 0.05. Thus, the average value of cadmium and LDL cholesterol has no significant difference. Compared to the 400 mg/kgBW and 500 mg/kgBW, the 600 mg/kgBW dose has the best effectiveness in reducing LDL cholesterol in white rats (Rattus norvegicus) after being induced with cadmium chloride. This study recommends consuming fresh Moringa leaves (Moringa oleifera) as much as 66.522 grams per human/day as an additional antioxidant and chelating agent.
The Effectiveness of Moringa Oleifera Leaf Extract on Hepatotoxic Case Reviewing from Cadmium, SGOT and SGPT Blood Levels in white Rats (Rattus norvegicus) Induced with Cadmium (Cd) Devi Puspitasari; Indah Lestari; Christ Kartika Rahayuningsih; Juliana Christyaningsih
Jurnal Teknokes Vol 15 No 3 (2022): September
Publisher : Jurusan Teknik Elektromedik, POLTEKKES KEMENKES Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/teknokes.v15i3.278

Abstract

Moringa leaf (Moringa oleifera Lamk.) is part of herbal plants that have been known for their good natural chelating agent and hepatoprotective properties, especially in hepatotoxic events due to cadmium (Cd) exposure, where flavonoid compounds are contained in the form of quercetin and kaempferol, vitamin A, vitamin C and several phenol components that can inhibit the accumulation of cadmium metals and neutralize free radicals by lowering SGOT and SGPT levels, so this study aimed to determine the effectiveness of moringa leaf extract (Moringa oleifera Lamk.) against hepatotoxic in white rats (Rattus norvegicus) induced with cadmium. This study was expected to provide potential of Moringa leaves in hepatotoxic case at dose 400 mg/kgwb, 500 mg/kgwb and 600 mg/kgwb in white rats. This research was an experimental study with quantitative analysis conducted at the Faculty of Veterinary Medicine, Airlangga University, Surabaya Health Laboratory Center, and Bakti Analisa Laboratory in November 2021 – July 2022. The independent variable was the dose of Moringa leaf extract and the dependent variables were levels of cadmium, SGOT and SGPT in white rat blood. Analysis of blood cadmium levels using an atomic absorption spectrophotometer and analysis of SGOT SGPT levels using the BS-200 Chemistry Analyzer. The results showed that the average blood cadmium, SGOT and SGPT levels in treatment group 1 were 0.0605 μg/dL, 260.175 U/L, and 143.85 U/L; in treatment group 2 were 0.075 μg/dL, 250.925 U/L and 77.575 U/L; in treatment group 3 were 0.08125 μg/dL, 171.475 U/L and 66.075 U/L. Based on statistical analysis of One-way Anova test, sig. p value > 0.05, there was no significant difference in cadmium and SGOT levels. Then, the results of the Kruskal wallis test on SGPT levels showed sig. p value > 0.05, there was no significant difference in all treatments. Moringa leaf extract at a dose of 600 mg/kgbw/day had the best effect as chelating agent and hepatoprotective compared to doses of 400 mg/kgbw/day and 500 mg/kgbw/day at cadmium induction for 10 days. From this study, we recommend to consume about 66,522 g/day Moringa fresh leaves as the natural chelating agent and hepatoprotector for overcoming acute hepatotoxic case. INDEX TERMS Moringa Leaves, Cadmium, SGOT, SGPT, Rattus norvegicus, Atomic Absorption Spectrophotometer, Chemistry Analyzer
Correlation Air CO Level with HbCo Level, Hemoglobin, and Blood Pressure to Street Vendors in The Gading Fajar Sidoarjo Street Vendor Area Indira Ayuni Sri Pramasti; Ayu Puspitasari; Lully Hanni Endarini; Christ Kartika Rahayuningsih
Jurnal Teknokes Vol 15 No 4 (2022): December
Publisher : Jurusan Teknik Elektromedik, POLTEKKES KEMENKES Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/teknokes.v15i4.504

Abstract

Motor vehicles emit exhaust gas emissions that produce pollutants, one of the compounds contained is carbon monoxide (CO). CO may cause intoxication in humans if exposed for a long time especially street vendors because the work area is filled with vehicle fumes containing CO gas. High CO levels in the air indicate HbCO levels to increase. The increased of HbCO levels will cause abnormal hemoglobin levels and induce vasoconstriction which makes blood pressure increase. The purpose of this study was to prove the correlation between CO levels in the air with HbCO, hemoglobin, and blood pressure levels to street vendors in the Gading Fajar Sidoarjo Street Vendor Area. This research uses the Conway diffusion cell method and is an analytic observational study with a cross sectional design implemented at the Surabaya Health Laboratory Center and the Hematology Laboratory of Medical Laboratory Technology Department Poltekkes Kemenkes Surabaya in March 2022. Blood tests was carried out on 25 street vendors using random sampling technique. The results showed that average air CO level was 11.0 ppm and 13.3 ppm; mean HbCO levels 0.87%; mean hemoglobin levels 14.4 g/dL; mean systolic blood pressure levels 128 mmHg; and the mean of diastolic blood pressure levels 80 mmHg. The data were analyzed using SPSS. The outcome of normality test showed that the data was not normally distributed. Statistical tests was performed using Spearman correlation. The conclusion showed there was correlation between air CO level with HbCO level, hemoglobin level, and blood pressure level on street vendors in the Gading Fajar Sidoarjo Street Vendor Area. If CO levels in the air increase, then HbCO levels and blood pressure also increase. Street vendors are expected to always use Personal Protective Equipment (PPE) such as mouth masks when working to reduce the risk of exposure to CO gas and doing a healthy lifestyle as a preventive effort to avoid health problems.
Co-Authors Alfiah, Siti Anik Handayati Anita Dwi Anggraini Aprilia Irmawati Aprilyadi, Nadi Astuti Setiyani Ayu Puspitasari Bambang Hadi Sugito Darjati Darjati Dedi Kurniawan Demes Nurmayanti Devi Puspitasari Devi Puspitasari Diah Titik Mutiarawati Evi Yunita N Hadi Suryono, Hadi Hotmaida Siagian Imam Khambali Indah Lestari Indah Lestari Indah Lestari Indira Ayuni Sri Pramasti Inggit Rianingtyas Ira Puspita Sari Isfentiani, Dina Juliana Christyaningsih Juliana Christyaningsih Kiaonarni OW Lembunai Tat Alberta, Lembunai Tat Luh Putu Rahayu Candra Dewi Lully Hani Endarini Lully Hanni Endarini Maruni Wiwin Diarti N. S. Widodo Ni Made Risma Fridayanti Nur Hatijah Retno Sasongkowati Rieke Dwi Ramadhany Riya Agustin Riya Agustin Sri Sulami Endah Astuti Suliati Suliati Sumasto, Hery Tacik Idayanti Teresia Retna Puspitadewi Vernanda Arsya Nabilla Winarni Winarni Woelansari, Evy Diah Yusianti Silviani