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All Journal Jurnal Kedokteran Brawijaya Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Reproduksi Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Universa Medicina Jurnal Gizi Klinik Indonesia Majalah Farmaseutik Jurnal Kesehatan Reproduksi Molekul: Jurnal Ilmiah Kimia Journal of Community Empowerment for Health JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

Mae Sri Hartati Wahyuningsih

- Department Of Pharmacology And Therapy, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada - Herbal Medical Center, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada

Author-ID : 287503

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Efek Minyak Esensial Lavender Dibandingkan dengan Minyak Esensial Jahe terhadap Intensitas Nyeri Menstruasi pada Remaja Wasis Pujiati; Mae Sri Hartati W; Elsi Dwi Hapsari
JURNAL KESEHATAN REPRODUKSI Vol 3, No 2 (2016)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Background: Menstrual pain is the pain in the abdomen which is perceived before or during menstruation, that even when the menstrual pain is heavily painful, the sufferers leave their activities. Research in 2011 showed that the rate of occurrence of primary menstrual pain in Indonesian adolescences was about 54.89%. Various therapies have been used to cure the pain, both pharmacologically and nonpharmacologically. Pharmacologically, it is done by the usage of NSAID, and non-pharmacologically is done by using essential oil.Objective: To know about the effects of lavender essential oil compared to ginger essential oil toward the intensity of menstrual pain in the adolescences of SHS 1 Muncar.Method: True experimental design, with randomized pretest posttest design plan. Time of data retrieval was August-September 2014 in SMA 1 Muncar, Banyuwangi, East Java. Population in this research were female adolescences in class of X and XI, with the amount of 260 students, with samples’ amount of 30 for each treatment group. The sampling technique was simple random sampling. The dependent variable are the giving of lavender and ginger essential oils, meanwhile the independent variable are the reduction of the intensity of menstrual pain. Instrument which was used was Numerical Rating Scale. The data analysis used the Wilcoxon and Mann-Whitney Test.Result and Discussion: The intensity of pain before and after intervention of essential oil of lavender and ginger are 5,47±1,19 vs 2,93±1,53, P=0,00 and 5,40±0,96 vs 2,93±1,43, P=0,00, respectively. Comparison of the effects essential oil of lavender and ginger have P >0,05.Conclusion: Both lavender essential oil and ginger essential oil are effective in reducing the intensity of menstrual pain in adolescences. Keywords: Menstrual pain, Essential oils, Lavender, Ginger, Adolescences

Pemberian jahe instan terhadap kejadian mual muntah dan asupan energi pada ibu hamil trimester pertama Nurfalah Setyawati; Mae Sri Hartati Wahyuningsih; Detty Siti Nurdiati
Jurnal Gizi Klinik Indonesia Vol 10, No 4 (2014): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18871

Background: Pregnancy causes increased energy metabolism, therefore needs of energy and other nutrients increase during pregnancy. Lack of energy and nutrients could adversely affect the mother and fetus. Nausea and vomiting is a common problem in the first trimester of pregnancy. If not treated the mother and fetus can be at risk of malnutrition due to lack of energy intake. Traditional treatment is an option that is considered safe. Ginger has been used to treat a variety of medical problems including nausea and vomiting. Ginger works in the digestive tract by increasing the gastric and intestinal motility.Objective: This study aimed to determine the effectiveness of instant ginger containing 290 mg ginger juice, to reduced the incidence of nausea and vomiting of pregnancy and increased maternal energy intake during the 24 hours.Method: The study design is experimental, the pre-post control group, involving 101 pregnant women with gestational age less than 15 weeks in RSB Sayang Ibu, puskesmas Klandasan Ilir and Sepinggan in Balikpapan. Research subjects were drawn at random and given the instant ginger or placebo, 2 times a day for a week. All of the subjects were assessed on the level of nausea, vomiting and a 24-hour energy intake during pre and post intervention. The use of drugs or supplementation from the doctor/midwife were recorded and not be stopped.Results: The rate of nausea and vomiting decreased significantly in the ginger group (52%) compared to placebo (17.7%) (p<0.05). Instant ginger may reduce nausea and vomiting rate 6 times higher than placebo (p<0.05). The average amount of energy intake (calories) for 24 hours increased significantly in the ginger group (1629.58 kcal ± 468.04 kcal; p<0.05) compared to placebo (1160.27 kcal ± 341.85 kcal; p>0.05). Instant ginger may increase the average amount of energy intake 24.5 times higher than placebo (p<0.05).Conclusion: Instant ginger effective to reduce nausea and vomiting of pregnancy and increase the amount of energy intake (calories) in pregnant women who experience nausea and vomiting of pregnancy.

Pemberian minuman secang (Caesalpinia sappan l.) terhadap kadar malondialdehid plasma dan kebugaran jasmani pada pegawai penderita prehipertensi Farida Fitriyanti; Susetyowati Susetyowati; Mae Sri Hartati Wahyuningsih
Jurnal Gizi Klinik Indonesia Vol 16, No 3 (2020): Januari
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Effect of Secang (Caesalpinia sappan L.) drink toward plasma-malondialdehyde level and physical fitness in prehypertensive government office workerBackground: Prehypertension is associated with a higher risk of hypertension and cardiovascular disease. A government office worker has lower physical activity, thus increasing the risk of hypertension, low physical fitness, and a higher level of oxidative stress. Free radical which is the product of oxidative stress can be reduced by antioxidants. Secang (Caesalpinia sappan L.) is one of the ingredients in a traditional herbal drink (jamu) and a natural source of antioxidants in the form of polyphenol.Objective: The purpose of this study is to discover the effect of secang drink supplementation, and efficacy towards plasma MDA level and physical fitness on a government office worker.Methods: This study conducted with true experimental by pre and post-test control group design. The subject is 35 prehypertensive government office workers aged between 25-45 years old in Yogyakarta, divided into treatment and control groups. Secang is given in 3.8g teabag which brewed in 200cc hot water, consumed for 4 weeks. Plasma MDA level is measured using TBARS, and physical fitness is measured using the Harvard step test. Results are analyzed using student paired t-test, Pearson and Spearman correlation test, regression test, and ANOVA.Results: There’s insignificant decrease of plasma MDA level between intervention group (from 4,28±3,16 to 3,66±1,21) and control group (4,85±2,35 to 3,65±1,33). There’s difference on Harvard step test results, intervention group increase from 35,54±20,18 to 48,09±21,86 in male, while 11,56±4,94 to 13,87±6,25 in female. In control group, male subject increase 29,20±10,06 to 38,18±23,62, but decrease 13,30±7,12 to 13,26±2,92 in female.Conclusions: 4 weeks drinks of 3.8 g Secang drink brewed in 200ml hot water, shows no evidence of lowering oxidative stress (MDA) in plasma, but it may increase physical fitness.

SITOTOXICITY OF COMPOUND ISOLATED FROM THE LEAVES OF TITHONIA DIVERSIFOLIA (HEMSLEY) A.GRAY) AGAINST T47D, MCF-7 AND EVSA-T CELLS Arfian Bela Mahardika; Subagus Wahyuono; Mae Sri Hartanti Wahyuningsih
Majalah Farmaseutik Vol 12, No 2 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Tithonia diversifolia (Hemsley) A. Gray) is one of the plants that are traditionally used to treat various diseases. The previous studies using Bioassay Guided Isolation methods has obtained the active compound (MTT, HeLa cells; IC50 9.776 g / mL). The cytotoxic effects of active compounds against breast cancer cells is unknown. This study aims to determine the cytotoxicity of theactive compound isolated from the leaves of T. diversifolia on breast cancer cells (T47D; MCF-7 and EVSA-T). The isolated compounds from T. diversifolia tested their cytotoxicity against breast cancer cells (T47D, MCF-7 and EVSA-T), using MTT method with a series of concentration of 0.39 to 50 ug/mL. Each concentration of the group performed triplicate and calculated the percentage of cell growth inhibition with probit analysis to calculate the IC50 value. The test results showed that the active compound have a cytotoxic effect on T47D, MCF-7 and EVSA-T cells with IC50 values are respectively (2.44; 4.697; 3.522) ug/mL, so this compound potential to be developed as an anticancer agent, especially breastcancer

Effect of Tithonia Diversifolia (Hemsley) A.Gray and Curcuma Domestica Val Extracts Combination Against Nodule and Body Weight In Cancer Rats Model Mae Sri Hartati Wahyuningsih; Wahyu Nur Halimah; Woro Rukmi Prtiwi
Majalah Farmaseutik Vol 13, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Kembang bulan [Tithonia diversifolia (Hemsley) A. Gray] is a potentially anticancer plants that have been previously shown have cytotoxics effect on WiDr colon cancer cells, IC50=61.55µg/mL. Turmeric (Curcuma domestica Val.) is widely used in traditional medicine. Curcuminoids compounds from turmeric have potential anticancer activity with possibly modulate immune function mediated by lymphocytes. With the immunostimulant effect of turmeric when mixed with kembang bulan as an anticancer candidate is expected to synergize better. This study aims to determine the potential of T. diversifolia and C. domestica ethanolic extracts combination in cancer rats model by measuring weight, number of nodules, and nodule volume animals. The study was a quasi-experimental study. Mixed 70% ethanol extract of kembang bulan’s leaves and turmeric’s rhizome divided into 3 doses, 40:150mg, 80:150mg, and 160:150mg. Then it given to each group of rats by orally that had experienced breast cancer . After that, see potential on body weight, number of nodules, and nodule volume. Then compared with normal group, negative control group, and positive control group. Furthermore, the percentage change in each treatment group were compared and statistically tested using ANOVA analysis. Comparison of the results of rat’s body weight between the control group (doxorubicin) and test group showed significantly no different results. Comparison of the results of rat’s breast cancer nodule volume between the control group and the test group showed significantly no different results. A combination of 70% ethanol extract of kembang bulan’s leaves and turmeric’s rhizome have no significant effect on body weight and breast cancer nodules.

Comparison of Methanol, Ethyl Acetates and Chloroform Extracts of Zingiber zerumbet (L) Smith in Larvisidal Activities on Aedes aegypti (Diptera: Culicidee) Larvae Tri Murini; Mae Sri Hartati Wahyuningsih; Tri Baskoro T.Satoto
Majalah Farmaseutik Vol 13, No 2 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The resistance of mosquito larvae to conventional larvicides has been increased in the recent years. Therefore, it is necessary to develop new larvacides from natural materials. Previous studies showed that Zingiber zerumbet (L.) Smith has a potential ability as a larvicide in Artemia salina Leach and Anopheles nunestovary. Nevertheless, the use of different solvents to observe the best larvicidal activity has not been known. This study aims to assess the larvicidal activity of methanol extract, ethyl acetate, and chloroform in Aedes aegypti larvae. This is an exploratory laboratory study with the posttest-only control group. The extraction solvents used were methanol, ethyl acetate, and chloroform. Twenty-five instar larvae (III-IV) of Ae.aegypti were treated with seven different concentrations of the three Z. rhizome extracts. The mortality rate of the larvae was calculated and analyzed using probit analysis regression to obtain LC50 and LC90 values. The LC50 of the methanol, ethyl acetate, and chloroform extracts are 153.57, 185.80, 3542.03 ppm; while the LC90 are 226.59, 274.70, and 5567.24 ppm, respectively. The study suggested that the methanol extract of Z. zerumbet rhizome has the most robust larvicidal activity against third-fourth instar larvae of Ae. aegypti among other extracts.

Effect of Extract Combination Tithonia diversifolia (Hemsley) A.Gray and Curcuma domestica Val. In Function of Heart and Kidney Rats of Cancer Model Angga Anugerah; Woro Rukmi Pratiwi; Mae Sri Hartati Wahyuningsih
Majalah Farmaseutik Vol 14, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Both Tithonia diversifolia (Hemsley) A. Gray leaves and (Curcuma domestica Val.) rhizome have bioactive compound which are an anticancer drug candidate. However, in vivo study about the effect of those to liver function and kidney function has never been carried out. The aim to determine the effect of ethanol extract T. diversifolia (Td) and C.domestica (Cd) combination to Sprague Dawley female rats liver and kidney function which have been induced with DMBA. This research used a quasi experimental study design. There were 31 female rats divided into 6 groups; healthy group; doxorubicin group; breast cancer model; extract combination I (n=5), extract combination II (n=5), extract combination III (n=5). DMBA used to initiate breast cancer was given twice a week for 5 weeks. After palpable breast cancer was showed up, the combination extract groups were given ethanol extract combination of kembang bulan leave and turmeric rhizome twice a day for 4 weeks orally with dosage ratio 40:150 mg/kgBW, 80:150 mg/kgBW, 160:150 mg/kgBW, respectively. Doxorubicin group was given 0,032mg/20gBW intraperitoneally once a day for 4 weeks. Liver and kidney function test were conducted on day 0 and the last day with SGOT, SGPT, Ureum and Creatinine level as the parameters measured. Comparison of liver and kidney function test results between extract combination groups and control groups showed no significant difference. The parameters measured were SGOT (p=0,847), SGPT (p=0,237), Creatinine (p=0,671), Ureum (p=459). Extract combination groups compared to control groups have no significant effect to liver and kidney function.

Optimasi Carbomer, Propilen Glikol, dan Trietanolamin Dalam Formulasi Sediaan Gel Ekstrak Etanol Daun Kembang Bulan (Tithonia diversifolia) Amira Fawwaz Tsabitah; Abdul Karim Zulkarnain; Mae Sri Hartanti Wahyuningsih; Dwi Aris Agung Nugrahaningsih
Majalah Farmaseutik Vol 16, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v16i2.45666

Ekstrak etanol daun kembang bulan atau Tithonia diversifolia telah diteliti memiliki kemampuan sebagai anti keloid yang baik. Tujuan penelitian ini adalah untuk mendapatkan formula gel dengan sifat fisik dan stabilitas yang baik. Metode yang digunakan dalam optimasi ini adalah Simplex Lattice Design. Formula optimum gel dibuat dari bahan carbomer, propilen glikol, dan trietanolamin. Parameter yang diukur adalah viskositas, pH, daya sebar, freeze and thaw cycles, dan sineresis. Hasil uji kemudian dianalisis menggunakan paired t-test.Hasil penelitian menunjukan bahwa formula optimum gel terdiri dari 0,81% carbomer, 5,9% propilen glikol, dan 0,58% trietanolamin dengan viskositas 155,96 d.Pas, daya sebar 4,06 cm, pH 5,50, dan sineresis 0,64%. Basis gel yang dihasilkan bening, memiliki viskositas 156,10 ± 2,87 d.Pas, daya sebar 3,95 ± 0,07 cm, pH 5,50 ± 0,00, dan sineresis 0,46 ± 0,00 %. Sediaan basis gel stabil dalam uji stabilitas fisik. Gel ekstrak etanol daun kembang bulan yang dihasilkan memiliki viskositas 77,70 ± 2,30 d.Pas, daya sebar 4,55 ± 0,21 cm, pH 5,32 ± 0,01, dan sineresis 1,42 ± 0,28 %. Sediaan gel ekstrak etanol daun kembang bulan kurang stabil dalam uji stabilitas fisik pada viskositas yang mengalami penurunan, daya sebar yang mengalami kenaikan, pH yang mengalami kenaikan, dan sineresis yang meningkat.

Penurunan Laktat Dehidrogenase Plasmodium falciparum strain D10 pada pemberian Fraksi Tithonia diversifolia (Hemsley) Rul Afiyah Syarif; Mae Sri Hartati Wahyuningsih; Mustofa Mustofa; Ngatidjan Ngatidjan
Majalah Farmaseutik Vol 17, No 1 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v17i1.57817

Penelitian terdahulu menunjukkan bahwa fraksi ke-6 (F6) merupakan fraksi aktif (F-akt) daun Tithonia diversifolia (Hemsley) A.Gray yang menghambat pertumbuhan Plasmodium. Pertumbuhan parasit ini memerlukan energi yang diperoleh dari aktivitas laktat dehidrogenase (LDH). Penelitian ini bertujuan mengkaji aktivitas antiplasmodium fraksi aktif T. diversifolia terhadap kadar LDH kultur P. falciparum. Kultur Plasmodium falciparum strain D10 stadium cincin dibagi menjadi kelompok eritrosit tidak terinfeksi (KTI), eritrosit terinfeksi (KI), dan eritrosit terinfeksi Plasmodium yang diberi F6 (F-akt) T. diversifolia (KI+F-akt) konsentrasi 9,38-150 µg/mL. Kultur diinkubasi 48 jam. Media kultur diukur kadar LDH-nya secara enzimatik. Adanya perbedaan LDH antar kelompok dianalisa dengan Anova. Penghambatan aktivitas LDH (IC50) ditetapkan dengan analisa probit. Kadar LDH kelompok KI (362,33 ± 133,18 U/L) lebih tinggi daripada KTI (270,33 ± 65,85 U/L) (p>0,05). Pemberian F-akt pada KI menyebabkan kadar LDH parasit lebih rendah daripada KI. Kadar LDH parasit yang diberi F-akt konsentrasi 9,38; 18,75; 37,50; dan 150 µg/mL secara berturut-turut adalah 365,5 ± 129,5; 210,5 ± 1,5; 195,5 ± 81,5; dan 111,5 ± 53,5 U/L. Tidak ada perbedaan kadar LDH antar kelompok penelitian (p>0,05). F-akt T. diversifolia mampu menghambat LDH P. falciparum strain D10 dengan nilai IC50 = 39,22 µg/mL.Kata kunci: Tithonia diversifolia, laktat dehidrogenase, Plasmodium falciparum

Ethanol Extract of Tithonia diversifolia (Hemsley) A Gray Standardized Ameliorates Hyperglycemia, Polyphagia, and Weight Loss in Diabetic Rats Yulia Fauziyah; Sunarti Sunarti; Ita Fauzia Hanoum; Mae Sri Hartati Wahyuningsih
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Diabetes mellitus is a state of chronic hyperglycemia which causes various complications. Traditionally, The Tithonia diversifolia (Hemsley) A Gray leaf has long been used for the treatment of diabetes. The aim of this study is to investigate the effect of the T. diversifolia leaf on blood glucose, polyphagia, and weight loss in a diabetic rat model. Rats were made diabetic with intraperitonial injection of Nicotinamide and Streptozotocin and divided into 5 groups. Group 1 were healthy rats, group 2 were diabetic rats, while groups 3, 4, and 5 were diabetic rats treated with 25, 50, and 100 mg/kg body weight of 70% ethanol extract of Tithonia diversifolia leaf respectively for 28 days. Blood was taken after treatment for measuring glucose. The ethanol extract of T. diversifolia leaf decreased blood glucose in diabetic rats (P<0.05). The ethanol extract of T. diversifolia leaf significantly suppresses polyphagia and improves diabetic rat weight (P <0.05). In conclusion, Tithonia diversifolia ethanolic extract has anti-hyperglycemic effect and ameliorated the effect of diabetes mellitus symptoms, namely polyphagia and weight loss.

Co-Authors Abdul Karim Zulkarnain Achmad Fudholi Adiguno Suryo W Adiguno Suryo W, Adiguno Suryo Alam, Gemini Amira Fawwaz Tsabitah Angga Anugerah Annisa Nurul Pratiwi Arfian Bela Mahardika Argo D, Imono Arief Budiyanto Arif Yusuf Wicaksana Astuti, Puji Bayu Putra Bolhuis RLH Catharina Widiartini Damiana Sapta Candrasari Desyandri Desyandri Detty Siti Nurdiati, Detty Siti Dewi Aryanti Dita Ayu Dewi Laras Sati Dwi Aris Nugrahaningsih Dwiki Yuliya Rahmawati Edy Meiyanto Elly Wahyudin Elly Wahyudin Elsi Dwi Hapsari Elsi Dwi Hapsari, Elsi Dwi Elvira Santi Eti Nurwening Sholikhah Farida Fitriyanti Farida Fitriyanti Firandi Saputra Firandi Saputra, Firandi Firdaus, Insanul Fitranto Arjadi Fudholi, Achmad - Gatot S. Lawrence Gatot S. Lawrence Hajid Rahmadianto Hajid Rahmadianto Mardihusodo Hajid Rahmadianto Mardihusodo, Hajid Rahmadianto Halimah, Wahyu Nur Hardyanto Soebono Hayati, Farida I Dewa Putu Pramantara Ibnu G Gandjar, Ibnu G Ibnu G. Gandjar Ibnu G. Gandjar Ibnu G. Ganjar, Ibnu G. Indwiani Astuti Indwiani Astuti Ishandono Dachlan Ita Fauzia Hanoum K. Nooter KV Rao, KV M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Mark T Hamann, Mark T Mark T. Hamann Mia Munawaroh Mirianti A. Manggau Mirianti A. Manggau, Mirianti A. Mufidah Mufidah Mufidah Mufidah Mustofa Mustofa Mustofa Mustofa Ngatidjan Ngatidjan Ngatidjan Ngatidjan Nia Krisniawati Nina Salamah Nina Salamah Nooter K Nugrahaningsih, Dwi Aris Agung Nungki Anggorowati Nur Arfian Nur Arfian, Nur Nur Falah Setyawati Nurfalah Setyawati Nyoman Nyoman Kertia Oostrum RG Pinus Jumariyatno Prasetyawati, Citra Prasetyo Tri Kuncoro Pratiwi, Woro Rukmi Probosuseno Probosuseno R.L.M. Bolhuis Rul Afiyah Syarif Sari, Dinar Sofia Mubarika Sofia Mubarika Sofia Mubarika Sofia Mubarika H Sri Kadarsih Soejono Sri Suharmi Sri Suharmi, Sri Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sugiyanto . Sugiyanto Sugiyanto Sunarti Sunarti Susetyowati Susetyowati Susetyowati Susetyowati, Susetyowati Tatsuo Takeya, Tatsuo Teguh Aryandono Tri Baskoro T.Satoto Tri Baskoro Tunggul Satoto Tri Murini Tri Murini Tri Murini Tri Murini Wahyu Nur Halimah Wahyuono, Subagus Wahyuono, Subagus Wasis Pujiati Woro Rukmi Pratiwi Woro Rukmi Prtiwi Yohanes Widodo Wirohadidjojo Yulia Fauziyah Yuliani, Fara Silvia Yuniyanti, Mia Munawaroh

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