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Journal : Indonesian Journal of Biotechnology

Identification of gene expression location of angiotensin‐converting enzyme‐2 SNPs as a receptor for SARS‐CoV‐2 in different populations by using various databases Dyah Aryani Perwitasari; Rita Maliza; Bayu Tri Murti; Haafizah Dania; Athika Darumas Putri
Indonesian Journal of Biotechnology Vol 26, No 2 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.63260

Abstract

The World Health Organization (WHO) has announced that Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) and Coronavirus disease (COVID‐19) is considered a worldwide pandemic. Rapidly rising numbers of patients have been reported in almost every country, along with the growing mortality rates. Uncontrolled growth in patient numbers may be due to reasons such as treatment options and vaccine availabilities and unidentified targets of SARS‐CoV‐2. Previous study has revealed that the molecular target of SARS‐CoV‐2 is analogous to SARS (2003), i.e. angiotensin‐converting enzyme‐2 (ACE‐2). Therefore, the determination of ACE‐2 may enrich existing information and facilitate development of drugs targeted toward SARS‐CoV‐2. This study aims to screen the expression of ACE‐2 genes and their relationship to the types of SNP variants in SARS‐CoV‐2. We explored a series of observations using powerful databases, e.g. GTEx portal, HaploReg, 1000 Genome and Ensembl, to identify the gene variant of ACE‐2. We showed that ACE‐2 is highly expressed in the testes and small intestine, while its lowest level is observed in lymphocytes. Subsequently, we observed 17 gene variants containing a missense mutation potentially damaging protein level. Among these genes, single nucleotide polymorphism (SNP) rs370187012 shows the highest damage‐level score, while the lowest effect is in SNP rs4646116. The highest frequency of the C allele was observed in European populations (1%). In addition to showing that ACE‐2 is expressed in several organs, we concluded that the ACE‐2 gene variation can be found in African, American, Southeast and East Asian, and European populations. The polymorphisms of ACE‐2 impact on the ACE2 protein structure and the binding capacity of the ACE‐2 receptor with the S‐Protein of SARS‐CoV‐2.
Co-Authors A.A Kaptein Abdi Wira Septama Adi Wira Septama Adnan Adnan Adnan Adnan Adnan Adnan Adnan, Adnan Ahmad Azrul Zuniarto Aisyi, Mururul Ajeng Diantini Akrom, Akrom Anak Agung Gede Sugianthara Ananda Muhammad Naafi, Ananda Muhammad Andalusia, Rizka Andriana Sari Andriana Sari Andriana Sari Anisa Nova Puspitaningrum Arief Muttaqien Arief Rahman Afief Arifin, Bustanul Ariska Wigatiningtyas Athika Darumas Putri Baiq Adelina Atbam Munawwarah Baiq Nurbaety Bambang Purwoko Barkah Djaka Purwanto Barkah Djaka Purwanto Baroroh, Faridah Bayu Prio Septiantoro Bayu Prio Septiantoro Bayu Tri Murti Berry H Putra Bramadi Arya Bustanul Arifin Candradewi, Susan Fitria Cut Fatia Ulfa Cut Fatia Ulfa Damayanti, Elok Dania Haafizah Darwis Darwis Denys Chichi Kusumastuti Desty Kusumaningsih Dewi Wulandari Dias Ananda Sulistya Didik Setiawan Eka Wuri Handayani Elli Nur Hayati Endang Darmawan Endang Yuniarti Endang Yuniarti Farah Bidara Fatimah Sri Kurniawati Febriana, Sri Awalia Fredrick Dermawan Purba Gugun Suhendra Gugun Suhendra Haafizah Dania Haafizah Dania Haafizah Dania Haafizah Dania Haafizah Dania Haridini Intan Mahdi Hazena Misgi Damayanti Hendrik Hendrik Herjanti Ratnawiningsih Husnul Khuluq I Nyoman Kertia Ikrimah Nisa Utami Imaniar Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Imaniar Noor Faridah Intan Fatah Kumara Irma Risdiana Irma Risdiana Irma Risdiana Jaka Pradika Jarir At Thobari Kania Agustina Kaptein, A.A Kertia, Nyoman Kurniawan, Nurcholid Umam Kurniyati, . Kurniyati, . Lalu M Irham Lalu Muhammad Irham Lamhot B Simanjuntak Lamhot B Simanjuntak Lisza Niarisessa Lutfi Sukma Pratiwi M Rifqi Rokhman M. Rifqi Rokhman Made Ary Sarasmita Mahdi, Haridini Intan Maliza, Rita Mardiana Puji Lestari Marwin Marwin Marwin Marwin Melinda Widianingrum Melinda Widianingrum Melodia Rezadhini Menit Ardhiani Menit Ardhiani Muh. Deni Kurniawan Muhammad AR Saputra Muhammad Ardhani Muhammad Dwi Suprobo Muhammad Fathurrahman Muhammad Husnul Kuluq Mukti A Berlian Muliyani, Muliyani Mulyani, Sri Mumfasiroh Saputri Musa Fitri Fatkhiya mustika muthaharah Mustika Muthaharah muthaharah, mustika Mutmainnah Siradjuddin Muttaqien, Arief Nabial Chiekal Gibran Nabilah Nabilah Nabilah Nabilah Naili Ra fi'ah Nanik Sulistyani Nasriyah, Chotijatun Nazhipah Isnani Nidia Yuni Lestari Nidia Yuni Lestari, Nidia Ninda Sari Wahyuningtyas Novi Milasari Nur Aida Nur Mahdi Nur Mahdi Nurcholid Umam Nurcholid Umam Kurniawan Nurcholid Umam Kurniawan Nurcholid Umam, Nurcholid Nurkhasanah Mahfudh Nurul Kodriati Nyoman Kertia Nyoman Kertia Oni Yulianta Wilisa Pendicho Eko Yuliyanto Prasandhya Astagiri Yusuf Prasasti, Dian Pratama, Kharisma Pratiwi, P.D. Putri Pertiwi Putri Rachma Novitasari Putri, Rr. Erni Kusuma Qarriy 'Aina Urfiyya Ra fi'ah, Naili Ratu Matahari Riana Prastiwi Handayani Rini, Vina Angga Rizka Andalusia Rizka Andalusia Rizka Novia Atmadani Robi’ah Adawiyah Rocky Cheung Rocky Cheung Sabaan, Wahid Saidah Rauf Santoso, Setiyo Budi Satibi Satibi Sawitri Sawitri Setiyo Budi Santoso Shabran Hadiq Sindy Cisna Ambarwati Siswandi Siswandi Siswandi Siswandi Siti Pandanwangi Siti Urbayatun Solikhah Sri Awalia Febriana Sri Handayani Gurning Sri Mulyani Sulastri Sulastri Susan Fitri Candradewi Susan Fitri Candradewi Susan Fitria Candradewi Tetie Herlina Triantoro Safaria Triantoro Safaria Ully Adhie Mulyani Ully Adhie Mulyani Vina Angga Rini Wahyu Rahmatulloh Wilisa, Oni Yulianta Wirawan Adikusuma Woro Supadmi Woro Supadmi Woro Supadmi Woro Supadmi Yeni Alfiana Ratnasari Yudha Rizky Nuari Yuli Rachmawati Yuli Rachmawati Zulkarnain Zulkarnain Zulkarnain Zulkarnain