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All Journal Medicina E-Jurnal Medika Udayana Jurnal Veteriner e-CliniC JBN (Jurnal Bedah Nasional) ISM (Intisari Sains Medis) : Jurnal Kedokteran Majalah Patologi Indonesia Jurnal Respirasi (JR) Neurologico Spinale Medico Chirurgico Jurnal Kedokteran Universitas Palangka Raya Indonesian Journal of Cancer Journal of Global Pharma Technology
Ni Putu Sriwidyani
Departemen Patologi Anatomi Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Journal : Medicina

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THE CHARACTERISTIC OF CYTOLOGICAL AND PCR TESTS RESULT OF FINE NEEDLE ASPIRATION (FNA) SPECIMEN FROM NECK LYMPH NODE/S ENLARGEMENT CLINICALLY DIAGNOSED AS TUBERCULOUS LYMPH ADENITIS Winarti, Ni Wayan; Sriwidyani, Ni Putu
Medicina Vol 43 No 3 (2012): September 2012
Publisher : Medicina

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Abstract

Diagnosis of Tuberculous (TB) lymph adenitis is still problematic due to paucibacillar. Since histopathological biopsy examination is relatively expensive and needs times, FNA is being more frequently chosen. The specimen from FNA can be processed for cytological and PCR tests, but there is no data available describe the characteristic of the result of both methods. Hence, study is needed in order to improve knowledge and health services. A cross sectional study had been conducted from January 1st   until December 31st   , 2011, at Anatomical Pathology Laboratory of Medical School of Udayana University/Sanglah Hospital and Biomolecular Laboratory of Medical School of Udayana University. The subjects were all patients with clinical diagnosis TB lymph adenitis who met the eligibility criteria. During 6 months, there were 46 patients included in the study. They were 65% female and 35% male. The age was ranging from 5 years old until 83 years old and 30-39 years old age group was the highest in number (39%). Positive cytology result was found in 22 cases (48%), while PCR test revealed no positive result. There was significant diference between positive and negative cytology test in pain sensation category, conversely in onset, number of enlarged lymph node/s, localization, conglomeration and fixation categories. If every single clinical character was marked with score 1, node/s with accumulative scores 4-6 showed no different cytology result with node/s with score 1-3. This study shows that in detecting TB lymph adenitis using FNA specimen, cytology test was be#er than PCR
MUTASI K RAS PADA KARSINOGENESIS KANKER KOLOREKTAL Sriwidyani, Ni Putu
Medicina Vol 44 No 2 (2013): Mei 2013
Publisher : Medicina

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Karsinogenesis kanker kolorektal merupakan proses multi-step, melibatkan berbagai abnormalitasgenetik. Mutasi gen K RAS sering ditemukan pada tumor ini. K RAS adalah gen yang menyandi proteinK ras, suatu produk proto-onkogen yang merupakan komponen penting pada jalur pensignalan darireseptor permukaan sel untuk mengontrol proliferasi, diferensiasi, dan kematian sel. Kebanyakanmutasi terjadi pada kodon 12 dan 13 dari ekson 1. Protein K ras mutan akan menyebabkan aktivasipersisten dari banyak signal downstream dari pertumbuhan dan survival sel. Pemeriksaan adanyamutasi pada gen K RAS memegang peranan penting pada prognosis dan terapi dari kanker kolorektal.[MEDICINA 2013;44:97-100].
Co-Authors Anak Agung Ayu Ngurah Susraini Angelia Ongko Prabowo annie minerva datui Bintang Dwi Oktaviani Desak Made Cittarasmi Saraswati Seputra Herlina Eka Shinta Herman Saputra Herman Saputra Herman Saputra Herman Saputra Herman Saputra Herman Saputra I Dewa Ayu Inten Primayanti I Gde Raka Widiana I Gede Budhi Setiawan I Gede Indradika Pratama Putra I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Sri Mahendra Dewi I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Ngurah Made Cesar Vajrashrava Sunantara I Gusti Ngurah Mayun I Gusti Ngurah Pratama Yuda Atmaja I Gusti Nyoman Sri Wiryawan I Kadek Yana Parastuta I Ketut Bawantika Adi Putra I Made Gotra I Made Muliarta I MADE MULIARTA . I Wayan Juli Sumadi I Wayan Sugiritama Ida Ayu Ista Nariswari Ida Ayu Jasminarti Dwi Kusumawardani Ida Ayu Jelantik Astuti Ida Ayu Krisna Cantika Dewi Ida Ayu Meilasari Dewi Ida Bagus Ardya Kurnia Wilananda Ivana Juliarty Sitanggang Jovi Carina Handoko Kadek Cindy Dwi Cahyani Kadek Denik Suastini Kadek Dwi Pradnyawati Kandy Rosa Ismalia Katrin Rotua Simbolon Ketut Mulyadi Komang Chandra Surya Dika Luh Ayu Widayanti Luh Ayu Widayanti Luh Komang Ayu Widhiaty Karang Luh Putu Iin Indrayani Maker Luh Yeni Laksmini M. Arif Perdana Ariyansyah Made Agus Cahya Nugraha Koriawan Moestikaningsih . Ni Gusti Ayu Agung Manik Yuniawaty Wetan Ni Kadek Ayu Maya Damayanti Ni Kadek Ayu Maya Damayanti Ni Made Mahastuti Ni Putu Ekawati Ni Wayan Candrawati Ni Wayan Winari Ni Wayan Winarti Nornazirah Binti Azizan Popi Imelda Margareth Sitompul Putra, Putu Krishna B. S. Putu Ayu Widya Pramesti Putu Erika Paskarani Putu Febry Krisna Pertiwi Putu Julia Chandra Devi Sang Ayu Putu Yuliantini Silvia Nuhyil Indriani Sumadi, I Wayan J. Sylvi Diahningrum Tjandra Kristiana Volman Tampubolon Wimpie I Pangkahila