This research aims to produce textbooks that are integrated with Islamic religious values. This type of research uses RnD development research with the ADDIE development model, the instrument used is a feasibility questionnaire for religious material experts, biotechnology material experts, media experts, language experts and a user response questionnaire totaling 27 respondents consisting of 3 lecturers and 24 students. The research results show feasibility religious material expert 84.70%, biotechnology material expert eligibility 100%, language expert eligibility 88.67% and media expert eligibility 83.30%, while user response test results with a value of 91.10% show that the textbook developed is a book teaching biotechnology integrated with Islamic religious values is very precise, very appropriate, very clear, very interesting and very easy for students to understand.