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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian CHEMICA Jurnal Teknik Kimia The Journal of Pure and Applied Chemistry Research Jurnal Kimia dan Kemasan JPM17: Jurnal Pengabdian Masyarakat EduChemia: Jurnal Kimia dan Pendidikan CHEMPUBLISH JOURNAL Jurnal Farmasi Sains dan Komunitas ALCHEMY Jurnal Penelitian Kimia JMM (Jurnal Masyarakat Mandiri) Walisongo Journal of Chemistry Jurnal Pengabdian Al-Ikhlas Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang JAPI (Jurnal Akses Pengabdian Indonesia) Jurnal Kimia dan Kemasan Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Multidisciplinary Applied Natural Science JAPI: Jurnal Akses Pengabdian Indonesia Journal of Peat Science and Innovation (JPSI) Nanggroe: Journal Of Scholarly Service Jurnal Pengabdian Masyarakat Charitas Jurnal Ilmiah Kesehatan Nanggroe: Journal of Scholarly Service Rafflesia Journal of Natural and Applied Sciences (RJNAS)
Alfanaar, Rokiy
Chemistry Study Program, Faculty Of Mathematics And Natural Sciences, Palangka Raya University, Palangka Raya, Central Kalimantan, Indonesia.
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Journal : Pharmaciana: Jurnal Kefarmasian

 1 
Cytotoxic effect of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b] furan-4,5-dione compound from the bark of faloak (Sterculia quadrifida R.Br) in breast cancer cells T47D Rollando, Rollando; Alfanaar, Rokiy
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (73.886 KB) | DOI: 10.12928/pharmaciana.v7i2.6699

Abstract

Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara for drug plant. The information of the active compound contained in the faloak bark yet specifically published. This study aims to determine the active compound contained in the faloak bark that have cytotoxic activity to T47D breast cancer cells. Extraction process using maceration method, isolation process using gradien isolation method, elusidation using combination of information of IR spectra, 1D-NMR, 2D-NMR and LC-MS, and cytotoxic activity test on T47D breast cancer cells using MTT method. The isolation result obtained that isolate of naphthoquinone derivative compound is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione with IC50 value on T47D breast cancer cell was 9,88 µg/mL and with an index selectivity value was 30,23. 
Cytotoxic effect of 2,3-dihydro-6-hydroxy-2-methylenenaphtho[1,2-b] furan-4,5-dione compound from the bark of faloak (Sterculia quadrifida R.Br) in breast cancer cells T47D Rollando Rollando; Rokiy Alfanaar
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (73.886 KB) | DOI: 10.12928/pharmaciana.v7i2.6699

Abstract

Faloak (Sterculia quadrifida R.Br) is used empirically by residents of East Nusa Tenggara for drug plant. The information of the active compound contained in the faloak bark yet specifically published. This study aims to determine the active compound contained in the faloak bark that have cytotoxic activity to T47D breast cancer cells. Extraction process using maceration method, isolation process using gradien isolation method, elusidation using combination of information of IR spectra, 1D-NMR, 2D-NMR and LC-MS, and cytotoxic activity test on T47D breast cancer cells using MTT method. The isolation result obtained that isolate of naphthoquinone derivative compound is 2,3-dihydro-6-hydroxy-2-methylenenaphtho [1,2-b] furan-4,5-dione with IC50 value on T47D breast cancer cell was 9,88 µg/mL and with an index selectivity value was 30,23. 
Co-Authors Arif Cahyo Imawan Chresiani Destiana Yoedistira Chresiani Destianita Yoedistira Chresiani Yoedistira Devi Natalia Dion Notario Dita Monita E. Monica Efriyana oksal Elda Alyatikah Fatchiyatun Ni’mah Fatiqin, Awalul Febri Nur Ngazizah FX Haryanto Susanto Gatut Ari Wardani I Nyoman, Sudyana, Indri Susanti Iqbal, Rendy Muhamad Jumina Jumina Karyadi Karyadi Kestrilia Rega Prilianti Krisfian Tata Aneka Priyangga Lilis Rosmainar M. H. Afthoni Markus Angkawijaya Marvin Horale Pasaribu Melany Melany Miranti Maya Sylvani Mokhamat Ariefin Monica, Eva Muhammad Hilmi Afthoni Mulani Jeni Lestari Tampubolon Mu’afa Purwa Arsana P. N. Alfiyandri Pandu Gizta Rapi Paksi Rahman, Sudarman Rasidah Rasidah Riaa Safitri Riandy Putra Rollando, Rollando Ruth Febriana Kesuma Ruth Febriana Kesuma Sandi Mahesa Yudhantara Shesanti Citra Riana Shesanti Citra Riana Siti Unvaresi Misonia Beladona Sri Juari Santosa Sultan Arif Rahmadianto Tety Wahyuningsih Manurung Thathit Suprayogi W. Swastika Yahya Febrianto Yehezkiel Steven Kurniawan Yofita Sandra, S.Pd., M.Pd., Zico Farlin, Dr. Budiwirman, M.Pd., Yohanes Edi Gunawan Yudhi Ekakristian Sahari Yuniati, Yuyun Yuyun Yuniati Yuyun Yuniati Zuri Rismiarti Zuri Rismiarti