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All Journal VALENSI Indonesian Journal of Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pharmacology and Clinical Pharmacy Research Journal of Pharmaceutical and Medicinal Sciences Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Majalah Farmasetika Jurnal farmasi UIN Alauddin Makassar Borneo Journal Of Pharmascientech Current Research on Biosciences and Biotechnology Farmasis: Jurnal Sains Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Borneo Journal of Pharmacy
Wahyuni Wahyuni
Faculty Of Pharmacy Universitas Halu Oleo
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Potensi Antibakteri Ekstrak Metanol dan Senyawa Aromatik dari Buah Wualae (Etlingera elatior) Sahidin Sahidin; Syefira Salsabila; Wahyuni Wahyuni; Fristiohady Adryan; Imran Imran
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 5, No. 1, May 2019
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (576.334 KB) | DOI: 10.15408/jkv.v5i1.8658

Abstract

Buah tanaman wualae (bahasa Tolaki) atau Etlingera elatior digunakan oleh masyarakat Tolaki (Sulawesi Tenggara) sebagai bumbu masak dan obat tradisional. Untuk mengungkap potensi tersebut, khususnya buah wualae, dilakukan kajian fitokimia dan farmakologi buah wualae. Kajian fitokimia meliputi isolasi dan penentuan struktur dikerjakan dengan metode kromatografi (kromatografi vakum cair dan kromatografi radial) dan spektroskopi (1H dan 13C NMR). Kajian farmakologi meliputi uji aktivitas biologi terhadap enam jenis bakteri (Bacillus subtilis FNCC 0060, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Salmonella enterica ATCC 14028, Staphylococcus aureus ATCC 25923, dan Streptococcus mutans ATCC 25175). Hasilnya menunjukkan tiga senyawa fenolik telah berhasil diisolasi dan diidentifikasi dari buah wualae yaitu asam vanilat (1), asam p-hidroksibenzoat (2), dan asam kumarat (3). Ketiga senyawa tersebut pertama kali dilaporkan berhasil diisolasi dari buah E. elatior. Aktivitas antibakteri ekstrak metanol buah wualae dan tiga senyawa hasil isolasi menunjukkan bahwa sampel tersebut paling aktif terhadap bakteri S. mutans. Dengan demikian aktivitas senyawa-senyawa hasil isolasi dari buah E. elatior  berkorelasi dengan aktivitas ekstrak metanol buah E. elatior  terhadap S. mutans, dimana senyawa paling aktif adalah asam vanilat. Ekstrak yang dominan mengandung asam vanilat dari tanaman ini dapat dikembangkan sebagai herbal antibakteri S. mutans seperti herbal karies gigi dan obat kumur. Kata kunci: Etlingera elatior, wualae, buah, senyawa aromatik, antibakteri. The fruits of wualae (Tolakinese) or Etlingera elatior is utilized by Tolakinese (Sulawesi Tenggara) as spices and traditional medicine. To reveal the potencies, a study on phytochemical and pharmacological aspects have been carried out. The phytochemical study includes isolation and structure determination used chromatography methods (vacuum liquid chromatography and radial chromatography) and spectroscopy methods (1H NMR and 13C NMR). Biological activity was evaluated against some bacteria that are Bacillus subtilis FNCC 0060, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Salmonella enterica ATCC 14028, Staphylococcus aureus ATCC 25923, and Streptococcus mutans ATCC 25175). The results showed that three aromatic compounds had been isolated and identified that are vanillic acid (1), p-hydroxybenzoic acid (2) and coumaric acid (3). All compounds are firstly reported that successfully isolated from fruits of Wualae. Antibacterial potency indicated that the methanol extracts and the isolated compounds are the most active towards S. mutans and have good activity correlation between the extracts and the compounds. Vanillic acid is the most active compound from E. elatior fruits. Thus, the extracts contain dominantly vanillic acid from          E. elatior fruits can be developed to be antibacterial herbals caused by S. mutans. Keywords: Etlingera elatior, wualae, fruits, aromatic compounds, antibacterial activity.
Co-Authors . Firdayanti A. N. T. A Mallarangeng Abdulkadir Kamaluddin Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Lubis Agung W. M. Yodha Amaliah Amaliah Andini Sundowo Andryani Ningsih Annisa Fatinah Gani Apriliani Apriliani Arfan Arfan Asman Sadino Asman Sadino Asriullah Jabbar Asriullah Jabbar Astrid Indalifiany Bafadal, Mentarry Baru Sadarun Baru Sadarun Dayatriana Muthalib Desyandri Desyandri Dewiyanti Madu Dian Munasari DIANTINI, AJENG - Fadhliyah Malik Fery Indradewi Armadany Fery Indradewi Armadany Firasmi Sangadji Fitrawan, La Ode Muhammad Fredy Talebong Fristiohady Adryan Gusti Ray Sadimantara Hendra Febriansyah I Sahidin I Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Imran Imran Imran Iren Meylani Jumadil Junli Hong La Ode MJ Purnama La Ode Muh. Fitrawan La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama M. Ardianti M. Hajrul Malaka Marianti A. Manggau Masrika, Nur Upik En Mesi Leorita Mesi Leorita Mirda Mirda Mirna Widasri Mohammad Ghozali Muh Hajrul Malaka Muh. Azdar Setiawan Muh. Hajrul Malaka Muh. Ilyas Yusuf Muhammad H Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad I. Yusuf Muhammad Ilyas Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Israwan Azis Muktiarni, Muktiarni Musdalipah Musdalipah N. Nohong Naimah Naimah Nur Indri Rahayu Nur Saadah Daud Nur Syifa Rahmatika Nuralifah Nuralifah, Nuralifah Parawansah Parawansah Parawansah Rahmat Muliadi Rathapon Asasutjarit Rina Andriani Rina Andriani Rina Andriani Rina Andryani Rina Maryanti Rini Hamsid Rini Hamsidi Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Saripuddin Saripuddin Saripuddin Sernita Sernita Sofa Fajriah Sri Hutami Lety Grashella Syefira Salsabila Tian Amalia Halik Ulan Dwi Shintia Vica Aspadiah Aspadiah Wa Ode Harnita Wa Ode Ida Fitriah Wa Ode Nurfinti Wa Ode Salma Wa Ode Siti Zubaydah Wa Ode Sitti Zubaydah Yodha, Agung Wibawa Mahatva Yuliansyah Yuliansyah Yulianti Fauziah