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All Journal Jurnal Gizi dan Pangan Jurnal Gizi Jurnal Kesehatan Masyarakat Indonesia MEDIA MEDIKA INDONESIANA Journal of Nutrition and Health JURNAL GIZI INDONESIA Journal of Nutrition College Sari Pediatri Universa Medicina Health Notions JURNAL ILMU KEFARMASIAN INDONESIA Medica Hospitalia World Nutrition Journal IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) BKM Public Health and Community Medicine
Hertanto Wahyu Subagio
Clinical Nutrition Department, Medical Faculty, Diponegoro University
Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Universa Medicina

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Zinc supplementation improves heme biosynthesis in rats exposed to lead Budi Santoso; Hertanto Wahyu Subagio; Lisyani Suromo; Henna Rya Sunomo
Universa Medicina Vol. 34 No. 1 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.3-9

Abstract

BACKGROUNDLead acetate (Pb) inhibits heme biosynthesis through inhibition of δ-aminolevulinic acid dehydrogenase (δ-ALAD), copro porphyrinogenoxidase, and ferro chelatase. Zinc supplementation increases lead-bindingmetallothionein proteins. The purpose of this study was to find evidence that zinc supplementation prior to lead exposure improves heme biosynthesis in ratsMETHODSThis was a randomized post-test only control-group design study involving 28 rats assigned to 4 groups (1 control and 3 treatment groups). The treatment groups were supplemented with zinc at doses of 0.2, 0.4, and0.8 mg daily by gavage for 3 weeks. From week 4 to 13, all groups wereexposed to lead 0.5 g/kg BW/day by gavage. At the end of week 13, δ-ALAD, erythrocyte protoporphyrin (EPP), and heme concentrations were determined by means of ELISA. One-way ANOVA, followed byBonferroni’s test was used to analyse the data.RESULTSMean δ-ALAD concentrations decreased from the control group down totreatment group 3 (0.24 ± 0.20; 0.15 ± 0.15; 0.12 ± 0.11; 0.05 ± 0.06 ng/mean per unit). Mean EPP concentrations decreased from the control group down to treatment group 3 (1.96 ± 0.50; 1.24 ± 0.24; 1.03 ± 0.05; 0.62 ± 0.16 ng/mL). Mean heme concentrations increased from the controlgroup up to treatment group 3 (8.07 ± 2.64; 10.11 ± 2.27; 10.04 ± 1.65;11.41 ± 2.58 μM). ANOVA followed by Bonferroni showed that EPP concentrations differed significantly between the control group and treatment group 3 (p=0.00).CONCLUSIONZinc supplementation prior to lead exposure improves heme biosynthesis in rats exposed to lead.
Co-Authors Adriyan Pramono Ag Soemantri Agustinus Soemantri Ali Manfaluthi Ahmad Amalia Sukmadianti Amalia Sukmadianti Amin Samiasih Annta Kern Annta Kern Nugrohowati Apoina Kartini Apoina Kartini Aryu Candra Bagoes Widjanarko Banundari Rachmawati Besari Adi Pramono Binar Panunggal Budi Santoso Camelia Bomaztika Sari Darmono SS Denny Apriyanto Dewi Masitha Dewi, Clara Rashinta Dian Ratna Sawitri EDI DHARMANA Edi Dharmana Enny Probosari Enny Probosari Etisa Adi Murbawani Eunika Lusiana Febe Christianto Febe Christianto Febriana Rahmawati Hardhono Susanto Hardono Susanto, Hardono Hartanti Sandi Wijayanti Henna Rya Sunomo Jennifer Setiawan Joriandhita Ramadhan Lisyani Suromo Luciana Sutanto M Herumuryawan M Mexitalia M Sakundarno MARTHA ARDIARIA Mexitalia Mexitalia Minidian Fasitasari Mohammad Zen Rahfiludin MR Arientasari Himawan MS Anam Muchlis Achsan Udji Muchlis Ahsan Udji Sofro Muhammad Heru Muryawan Muhammad Sulchan Muji Mulyati Nanan Sekarwana Nathalia Safitri Niken Puruhita NUGRAHANINGSIH NUGRAHANINGSIH Nurrohmiati, Siti Nuryanto Nuryanto Nyoman Suci Widyastiti Phitra Sekar Dianggra Pusaka, Semerdanta Retnaningsih - Rimahardika, Rosita Riwanto Rosa Kristiansen Roziana Roziana, Roziana RRJ. Sri Djokomoeljanto Santi Rahayu SARJADI SARJADI Sofyan Harahap Sri Djokomoeljanto suhartono - Suhartono Suhartono Suhartono, Suhartono Suharyo Hadisaputro Suharyo Hadisaputro Suratman Suratman Taufik Hilmansyah Ulfa, Viny Rosaliana Wendiranti, Catra Ibriza Widya Budiarni Wijayanto Wijayanto Wiwid Widiyatni Wiwid Widiyatni, Wiwid Yuliyani, Ni Nyoman Sri