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All Journal Jurnal Gizi dan Pangan Jurnal Gizi Jurnal Kesehatan Masyarakat Indonesia MEDIA MEDIKA INDONESIANA Journal of Nutrition and Health JURNAL GIZI INDONESIA Journal of Nutrition College Sari Pediatri Universa Medicina Health Notions JURNAL ILMU KEFARMASIAN INDONESIA Medica Hospitalia World Nutrition Journal IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) BKM Public Health and Community Medicine
Hertanto Wahyu Subagio
Clinical Nutrition Department, Medical Faculty, Diponegoro University
Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : JURNAL ILMU KEFARMASIAN INDONESIA

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Ekspresi VEGF Sel Adenokarsinoma Mamma Pada Pemberian Oral Ekstrak Andrographis paniculata NUGRAHANINGSIH NUGRAHANINGSIH; SARJADI SARJADI; EDI DHARMANA; HERTANTO WAHYU SUBAGIO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Angiogenesis was needed to fulfill nutrition and oxygen demand for tumor growthh and its metastase. Vascular endothelial growth factor (VEGF) was a potential proangiogenic factor of angiogenesis process. In vitro study of Andrographis paniculata extract showed decreasing tend of VEGF level serum on PC-3 cancer cell line. The aim of this study was to prove the effect of oral administered Andrographis paniculata extract on VEGF expression of adenocarcinoma mammae C3H mice. Twenty four mice was transplanted with adenocarcinoma mammae randomly to four groups. Andrographis paniculata extract at dose 5, 10, and 15 mg/day were given on mice group along 14 days. One group another as a control. VEGF expression were examined use immunohistochemistry staining. Anova test showed difference VEGF expression among reseach groups (p=0,000, r=-0,953). The highest of VEGF expression index 24,8 was found on control group, and the lowest 19,4 was found on group which received 15 mg/day. We concluded that oral administration of Andrographis paniculata extract decreased VEGF expression of adenocarcinoma mamme C3H mice.
Co-Authors Adriyan Pramono Ag Soemantri Agustinus Soemantri Ali Manfaluthi Ahmad Amalia Sukmadianti Amalia Sukmadianti Amin Samiasih Annta Kern Annta Kern Nugrohowati Apoina Kartini Apoina Kartini Aryu Candra Bagoes Widjanarko Banundari Rachmawati Besari Adi Pramono Binar Panunggal Budi Santoso Camelia Bomaztika Sari Darmono SS Denny Apriyanto Dewi Masitha Dewi, Clara Rashinta Dian Ratna Sawitri EDI DHARMANA Edi Dharmana Enny Probosari Enny Probosari Etisa Adi Murbawani Eunika Lusiana Febe Christianto Febe Christianto Febriana Rahmawati Hardhono Susanto Hardono Susanto, Hardono Hartanti Sandi Wijayanti Henna Rya Sunomo Jennifer Setiawan Joriandhita Ramadhan Lisyani Suromo Luciana Sutanto M Herumuryawan M Mexitalia M Sakundarno MARTHA ARDIARIA Mexitalia Mexitalia Minidian Fasitasari Mohammad Zen Rahfiludin MR Arientasari Himawan MS Anam Muchlis Achsan Udji Muchlis Ahsan Udji Sofro Muhammad Heru Muryawan Muhammad Sulchan Muji Mulyati Nanan Sekarwana Nathalia Safitri Niken Puruhita NUGRAHANINGSIH NUGRAHANINGSIH Nurrohmiati, Siti Nuryanto Nuryanto Nyoman Suci Widyastiti Phitra Sekar Dianggra Pusaka, Semerdanta Retnaningsih - Rimahardika, Rosita Riwanto Rosa Kristiansen Roziana Roziana, Roziana RRJ. Sri Djokomoeljanto Santi Rahayu SARJADI SARJADI Sofyan Harahap Sri Djokomoeljanto suhartono - Suhartono Suhartono Suhartono, Suhartono Suharyo Hadisaputro Suharyo Hadisaputro Suratman Suratman Taufik Hilmansyah Ulfa, Viny Rosaliana Wendiranti, Catra Ibriza Widya Budiarni Wijayanto Wijayanto Wiwid Widiyatni Wiwid Widiyatni, Wiwid Yuliyani, Ni Nyoman Sri