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All Journal Jurnal Veteriner Indonesian Journal of Human Nutrition Jurnal Media Gizi Indonesia (MGI) Masyarakat, Kebudayaan dan Politik Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Preventia Health Notions Jurnal Ilmiah Universitas Batanghari Jambi Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Journal of Applied Food Technology Jurnal Kesehatan Prima Indonesian Journal of Medicine Journal of Maternal and Child Health Amerta Nutrition Darmabakti Cendekia: Journal of Community Service and Engagements Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Abdimasku : Jurnal Pengabdian Masyarakat Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Kesehatan Tambusai Nutrisia Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) STRADA Jurnal Ilmiah Kesehatan Jurnal Keperawatan
Annis Catur Adi
Departemen Gizi Kesehatan Fakultas Kesehatan Masyarakat, Universitas Airlangga, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Preventia

 1 
PENGARUH GLUTAMIN & GLUKOSA UNHIDRAT PADA JUMLAH LIMFOSIT TIKUS MODEL KURANG ENERGI PROTEIN Septa Katmawanti; Bambang Wirdjadmaji; Annis Catur Adi
Preventia : The Indonesian Journal of Public Health Vol 1, No 1 (2016)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.859 KB) | DOI: 10.17977/um044v1i1p25-34

Abstract

Abstract: Protein-energy malnutrition condition causes lymphocytes number to decrease which then lead to body's cellular immune system disorders, the condition where patient is more vulnerable to infection. Number of lymphocytes in the body is dependent to some factors, some of them are anti-oxidant, amino acid glutamine and glucose. The aim of his research is to study the effect of L-glutamine and glucose unhidrate administration in rat model of protein-energy malnutrition to the increase of lymphocytes number in the blood. This is an experimental study with Completely Random Design. Sample is malnutrition induced with parched rice for 15 days (n=20). Then some samples are examined to figure out the lymphocytes number after the rate model experience lack of energy and protein. Sample is then divided into four treatment groups, they are: group with normal diet (control), normal diet + L-glutamine, normal diet + glucose unhidrate, and normal diet + L-glutamine + glucose unhidrate. Lymphocytes content is measured again after 10 days. The result of the study shows that number of lymphocytes increase significantly (P<0.05) in the four treatment groups after the intervention compared with number of lymphocytes in the malnutrition induced group. Statistical analysis of the four groups with L-glutamine and glucose unhidrate administered shows significant difference each other (p<0.05). These observations imply that the glutamin and gluocose unhidrat has an effect to the increase of lymphocytes number in the blood.Keywords: Protein-Energy Malnutrition (PEM), lymphocyte, l-glutamine, glucose unhidrateAbstrak: Kondisi KEP menyebabkan penurunan jumlah limfosit yang mengakibatkan gangguan sistem imun seluler tubuh, sehingga penderita menjadi lebih rentan terhadap infeksi. Jumlah sel limfosit pada tubuh dipengaruhi oleh beberapa faktor antara lain keberadaan antioksidan, asam amino glutamin dan glukosa. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian glutamin dan glukosa unhidrat pada tikus model KEP terhadap kenaikan jumlah limfosit darah. Studi ekperimental menggunakan metode Rancang Acak Lengkap. Sampel diinduksi malnutrisi dengan nasi aking (karak) selama15 hari (n=20). Kemudian subsampel diperiksa untuk mengetahui jumlah limfosit setelah tikus mengalami kekurangan energi dan protein. Sampel kemudian dibagi menjadi empat kelompok perlakuan, yaitu kelompok dengan diet normal (kontrol), diet normal + glutamin, diet normal + glukosa unhidrat, dan diet normal + glutamin + glukosa unhidrat. Kadar limfosit diukur kembali setelah 10 hari. Hasil penelitian ini menunjukkan bahwa setelah dilakukan intervensi terdapat kenaikan jumlah limfosit secara bermakna (P<0,05) pada keempat kelompok perlakuan dibandingkan dengan jumlah limfosit pada kelompok induksi malnutrisi. Analisis secara statistik pada keempat kelompok yang diberikan intervensi Glutamin dan glukosa unhidrat menunjukkan bahwa terdapat perbedaan yang bermakna satu sama lain (p<0,05).Kata kunci: Kekurangan Energi Protein (KEP), limfosit, glutamin, glukosa unhidrat
Co-Authors Abdurrahman Ali Adinda Nurul Istiqomah Adiningsih, Sri Alfian Yusuf Ali Iqbal Tawakal Ali Iqbal Tawakal Alristina, Arie Dwi Alzha Adila Harisina Amirah Adlia Andini Octaviana Putri Anggun Pinasti Ilahi Anna Surgean Veterini Anna Surgean Veterini Anni Syntya Annisa Lutfiah Annisa Rizky Malichati Annisa Rizky Maulidiana Arina Mufida Ersanti Arisya Humaira Asrul Bahar Atsarina Anindya Aulanni'am, Aulanni'am Aulanni’am Aulanni’am Bambang Wahjuprajitno Bambang Wirdjadmaji Bambang Wirdjadmaji, Bambang Brilliant Anjar Saputro Chatarina Umbul Wahyuni Chatarina Umbul Wahyuni Cindhy Pamela Kesuma Claudia Ni Luh Merry Marzeline Daniel Christanto Deandra Ardya Regitasari Deandra Ardya Regitasari Diah Patria Nuringtyas Dian Puteri Andani Dina Khomariyatul Hasanah Dini Andrias Andrias Dini Ririn Andrias Dominikus Raditya Atmaka Dyah Patria Nuringtyas Edinda Ayu Miranti Elya Sugianti Emyr Reisha Isaura Emyr Reisha Isaura Emyr Reisha Ishaura Endah Bardiati Eny Qurniyawati Eva Flourentina Kusumawardani Eva Flourentina Kusumawardani Faradillah Rahmy Savitri Faradita Meilinda Wulan Sari Farah Rosyihana Fadhila Farapti Farapti Farapti Fariani Syahrul Fariani Syahrul Fathrizqita Aghnia Raudhany Fathrizqita Aghnia Raudhany Febry Dian Permatasari Fifi Nirmala G Hamzah Hamzah Hari Basuki Notobroto Haryana, Nila Reswari HENI RACHMAWATI Heni Rachmawati Heni Rachmawati Heni Rachmawati Heni Rachmawati Heni Rachmawati Hernita Riski Hikmah Ervina Jayantini I Ketut Sudiana I Ketut Sudiana Iga Ayuni Fatmala Iga Ema Dini Ikeu Ekayanti Ikhtiar, Ilham Irfa Ekasanti Irma Sarita Rahmawati Irwanto idris Irwanto Irwanto Irwanto, Irwanto Ivan Mahardika Yusuf Junaida Astina Kartini Kartini Kusumawardani, Eva Flourentina Lailatul Muniroh Lailia Wahyuliana Lathifah Ilmawati Laura Navika Yamani Lina Nurbaiti Lisda Juniarsy Rahardjo Luki Mundiastuti M. G. Bagus Ani Putra Mardiyono Yono Mei Lestari Ika Widyyati Melissa Ruslan Merryana Adriani Merryana Adriani Meyrina Putri Cahyariani Muhammad Atoillah Isfandiari Nabillah Eka Permatasari Nancy Margarita Rehatta Nanik Handayani Nelly Setiawaty Niken Ayu Br Sinaga Novira Dian Rachmadia Nur Mufida Wulan Sari Nuthathai Sutthiwong Puspitasari, Prastiwi Novia Putra, M.G. Bagus Ani Putri Safrida Rahmawati Rachmad Suhanda Rahmawati, Irma Sarita Rakhmalia Imeldawati Ratna Candra Dewi Rehatta, Nancy Margarita Reza Yuanita Ananta Rifqi, Mahmud Aditya Riris Diana Rachmayanti Rita Ismawati Rita Ismawati Rizky Arifandy Amir S R Widya Areta Humaniora Justisia Sakinah Aljuffrie Santi Martini Sarmanu Sarmanu Sarmanu Sarmanu Septa Katmawanti, Septa Shrimarti R Devi Siti Nur Husnul Yusmiati Siti Rahayu Nadhiroh Siti Shofiya Novita Sari Soetjipto Soetjipto Soetjipto Soetjipto SRI LESTARI Subijanto Marto Soedarmo Subijanto Marto Soedarmo Suryanto Suryanto Suryanto Suryanto Syafrina Mareta Sari Timbuktu Harthana Tri Ratnaningsih Tri Ratnaningsih Trias Mahmudiono Ulfatul Karomah Vetty Silvana Maulida Vidya Anggarini Rahmasari Vidya Anggarini Rahmasari Widati Fatmaningrum Widati Fatmaningrum Widijiati Widijiati Widjiati Widjiati Widodo Jatim P Widodo Jatim Pudjirahardjo Widyyati, Mei Lestari Ika Wizara Salisa Wizara Salisa Wizara Salisa Wizara Salisa Yama Dharma Putera Yasmin Muntaza Yeni Susanti Yulia Kurnia Sari Yusmiati, Siti Nur Husnul Yusuf, Alfian