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All Journal Jurnal Teknologi Industri Pertanian Jurnal Kimia (Journal of Chemistry) Bionatura Farmaka Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY Jurnal Keselamatan Radiasi dan Lingkungan IDJP (Indonesian Journal of Pharmaceutics) Jurnal Penelitian Pendidikan IPA (JPPIPA) Chimica et Natura Acta Jurnal Biologi Tropis Indonesian Journal of Chemistry Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Majalah Farmasetika Kumawula: Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Biological Pharmacy Jurnal Sains dan Teknologi Farmasi Indonesia

Muchtaridi Muchtaridi

Departemen Analisis Farmasi Dan Kimia Medisinal - Fakultas Farmasi - Universitas Padjadjaran

Author-ID : 2696308

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Molecular Docking Study of Mangosteen (Garcinia mangostana L.) Xanthone-Derived Isolates as Anti Androgen Cecep Suhandi; Ersa Fadhilah; Nurfianti Silvia; Annisa Atusholihah; Randy Rassi Prayoga; Sandra Megantara; Muchtaridi Muchtaridi
Indonesian Journal of Cancer Chemoprevention Vol 12, No 1 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss1pp11-20

Androgen receptor (AR) is the member of steroid hormone receptor involved in the progression of prostate cancer growth due to receptor over-activation. On the other hand, mangosteen (Garcinia mangostana L.) as a medicinal plant contains xanthone-derived compounds which were known to have cytotoxic activity towards any types of human cancer cells. This research aims to determine xanthone-derived isolates potency from mangosteen as AR antagonists. The study was carried out through molecular docking assay utilizing AutoDock 4.2.6 using androgen receptor obtained from PDB ID 2AM9, testosterone as native ligand, and bicalutamide, flutamide, and nilutamide as reference. The results indicated that three isolates (1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone, mangostinone, and trapezifolixanthone) have the highest potency to be AR antagonist seen from the lower bond-free energy value than all of reference ligand. The lowest bond-free energy was provided by mangostinone with a ΔG value of -10.05 kcal/mol. However, the highest difference of residual amino acids interaction with testosterone and similar interaction with bicalutamide was provided by 1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone, with five different amino acids with testosterone and nine similar amino acids with bicalutamide, respectively. Interestingly, 1,3,7-trihydroxy-2,8-di-(3-methylbut-2-enyl)xanthone has similar hydrogen bond with the key residue amino acids of AR (705-Asn and 711-Gln) which indicates probably partial agonist activity while mangostinone has the highest amount of hydrogen bond in the absence of hydrogen bond towards key residual amino acids of AR. The results concluded that three specific derived-xanthone compounds were predicted to have activity as AR antagonists.Keywords: Prostate cancer, Androgen receptor, Mangosteen, Xanthone, Molecular docking.

RETRACTED: Promosi Preventif SADARI (Periksa Payudara Sendiri) di Desa Sayang sebagai Upaya Pencegahan Kanker Payudara Muchtaridi Muchtaridi; Eli Halimah; Nasrul Wathoni
JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) VOL. 5 NOMOR 2 SEPTEMBER 2021 JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat)
Publisher : Universitas Muhammadiyah Purwokerto

Berdasarkan hasil penyelidikan secara teliti dan hati-hati terhadap artikel berjudul "Promosi Preventif SADARI (Periksa Payudara Sendiri) di Desa Sayang sebagai Upaya Pencegahan Kanker Payudara" yang terbit pada JPPM Vol 5 No. 2 September 2021.Artikel ini ditemukan melanggar etika publikasi JPPMArtikel ini mengandung isi yang sama pada artikel di Jurnal Kumawula: Jurnal Pengabdian kepada Masyarakat Vol 4 No. 1 th 2021 dengan link: http://jurnal.unpad.ac.id/kumawula/article/view/31966Dokumen dan isinya telah dihapus dari JPPM, dan upaya yang wajar harus dilakukan untuk menghapus semua referensi ke artikel ini.

Application of Ion-Exchange Resin Column for Basic Development of Strontium-90/Yttrium-90 Generator for Preparation of Radiopharmaceutical Therapy Muchtaridi Muchtaridi; Elvan Kamal; Anas Subarnas; Abdul Mutalib
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

The aim of this study is to examine the possible use of ion-exchange resin on Dowex AG 50x8 in separating Y-90 from Sr-90 which then could be applied in the basic of manufacture of producing Sr-90/Y-90 generator for the production of radiopharmaceutical cancer therapy. The findings showed that a distributive coefficient of Sr-90 and Y-90 with HCl 6 N solvent showed that distributive coefficient of Sr-90 in cation-exchange resin on Dowex 50x8 was greater than Y-90. Y-90 in HCl 6 N solvent was more easily eluted, while Sr-90 was bound to resin.. In conclusion, resin on Dowex AG 50x8 with HCl 6 N elution solvent might be able to separate Y-90 from Sr-90 as the basis for Sr-90/Y-90 generator.

Kajian Toksisitas Tanaman Genus Garcinia Wa Ode Ida Fitriah; Tiana Milanda; Muchtaridi Muchtaridi
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.7691

Sekitar 80%, alternatif dalam terapi pemeliharaan kesehatan bergantung pada penggunaan obat tradisional. Obat tradisional berasal dari bahan dan teknik pengobatannya yang bersifat alami, sehingga efek sampingnya relatif rendah, memiliki kandungan senyawa yang beraneka ragam bersifat sinergis serta biaya pengobatannya lebih ekonomis. Tanaman genus Garcinia merupakan famili dari Clusiaceae memiliki 400 spesies, 77 spesies diantaranya tersebar di wilayah Indonesia dan tumbuh di daerah tropis. Tanaman ini memiliki potensi besar sebagai obat tradisional dalam mengobati berbagai jenis kelainan patofisiologi. Pemanfaatan tanaman sebagai obat tradisional sebagian besar didasarkan pada pengalaman, namun informasi tentang bukti keamanan atau toksisitas tanaman obat kepada masyarakat masih terbatas sehingga perlu dilakukan pengkajian toksisitas genus Garcinia. Spesies tanaman dari genus Garcinia yang telah diuji toksisitasnya antara lain, Garcinia brasiliensis Mart., Garcinia xanthochymus Hook.f. ex T.Anderson, Garcinia cowa Roxb., Garcinia pedunculata Roxb. ex Buch.-Ham., Garcinia husor, Garcinia kola Heckel, Garcinia benthami Pierra, Garcinia mangostana L., Garcinia indica (Thouars) Choisy, Garcinia hombroniana Pierre, Garcinia rubroechinata Kosterm., Garcinia achachairu Rusby, Garcinia atroviridis Griff. ex T. Anders, Garcinia forbesii King, dan Garcinia multiflora Champ. ex Benth.

Radiochemical Purity Test of Fractionated Sestamibi Kit Labelled with Technetium-99m Hasna Chaerunisa; N. Elly Rosilawati; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.33332

Coronary Heart Disease (CHD) is a heart disorder caused by blockage of blood vessels. CHD can bedetected by Myocardial Perfusion Imaging (MPI). MPI is performed by injecting a radiopharmaceuticalinto the patient's body. 99mTc-sestamibi is a radiopharmaceutical that is commonly used in MPI.Sestamibi is available in the form of a multidose vial, but the cost of the examination will be expensiveif it is only used for one patient. Cost effectiveness can be increased by fractionating the sestamibi kitbefore labelled by 99mTc. 99mTc-sestamibi needs to be tested for quality control before it is administeredto the patients. One of the tests is the radiochemical purity test. The aim of this study was to determinethe radiochemical purity of the fractionated sestamibi kit labelled by 50 mCi 99mTc. 2 vials of sestamibikit were fractionated by adding 5 mL of 0.9% NaCl solution to each vial and divided into 10 new vials.Radiochemical purity was measured using the thin layer chromatography (TLC) method. The resultsof this study indicated that all samples had radiochemical purity of 100% up to 6 hours after labelling.

Studi In-Silico Ekstrak Dalam Tanaman Ranti (Solanum nigrum) Sebagai Inhibitor Jak2 pada Penyakit Leukemia Limfoblastik Christine Christine; Fathia Pebriani; Muhammad Ariq Al Faruq; Carla Florencia; Muchtaridi Muchtaridi
Indonesian Journal of Biological Pharmacy Vol 2, No 1 (2022): IJBP (April)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v2i1.38126

Leukemia Limfoblastik Akut (LLA) merupakan penyakit hematologi heterogen yang ditandai dengan proliferasi sel limfoid imatur di sumsum tulang, darah tepi, dan organ lainnya karena adanya mutasi pada reseptor JAK. Beberapa tahun terakhir, strategi baru yang menargetkan protein terkait penyakit untuk degradasi seperti Proteolysis targeting chimerics (PROTAC) diteliti. Penelitian ini bertujuan untuk studi in silico aktivitas senyawa penghambat STAT 3 dan JAK 2 pada tanaman ranti (Solanum nigrum L.). Pengujian dilakukan menggunakan perangkat lunak meliputi, ChemOffice 2019, AutoDockTools 1.5.6., BIOVIA Discovery Studio 2021, dan Ligandscout. Dari 17 senyawa tanaman ranti yang diuji, hanya 11 senyawa yang memenuhi aturan Lipinski rules of five dan prediksi ADMETOKS yang kemudian dilanjutkan dengan penambatan molekul. Hasilnya, senyawa N-Acetyl-L-tryptophan ethyl ester dinilai paling berpotensi sebagai antikanker, meskipun memiliki energi gibbs yang lebih rendah sebesar -6.38 kcal/mol apabila dibandingkan dengan ligan alaminya yakni -8.19 kcal/mol. Hasil menunjukkan tanaman ranti (Solanum nigrum L.) berpotensi sebagai kandidat pengobatan LLA, namun masih butuh penelitian lebih lanjut dengan perangkat lunak yang lebih lengkap.

PEMAHAMAN MASYARAKAT TERKAIT PEMBUDIDAYAAN CACING LUMBRICUS DAN PEMASARAN KANAL DIGITAL UNTUK KEBUTUHAN SEDIAAN OBAT HERBAL MELALUI MEDIA WORKSHOP Muchtaridi Muchtaridi; Sandra Megantara; Muhammad Syahid Abdillah; Sitti Faza Karima; Nabila Alivia Yasmin; Ganendra Akbar Hadiyanto
Kumawula: Jurnal Pengabdian Kepada Masyarakat Vol 5, No 2 (2022): Kumawula: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/kumawula.v5i2.38657

Kampung Batu Lonceng, Desa Suntenjaya, Kecamatan Lembang merupakan salah satu daerah usaha tani dan ternak yang ada di Indonesia. Penelitian ini dilakukan untuk mengetahui tingkat pengetahuan dan pemahaman masyarakat di Desa Suntenjaya, Kecamatan Lembang mengenai budidaya cacing dan digital marketing. Cacing tanah juga memiliki manfaat lain yaitu pada bidang medis. Cacing tanah dapat digunakan sebagai obat penurun panas, demam dan obat tipus. Penggunaan cacing tanah sebagai obat diproses dengan cara dikeringkan dan diekstrak dalam bentuk kapsul. Penelitian ini menggunakan random sampling survey terhadap 21 warga Desa Suntenjaya yang mengisi kuesioner secara luring di tempat. Kategori tingkat pengetahuan responden ditentukan berdasarkan pengkategorian Arikunto (2013). Hasilnya tingkat pengetahuan masyarakat di Desa Suntenjaya mengenai budidaya cacing dan digital marketing dikategorikan kurang baik dengan rata-rata skor ≤ 9%.

Molecular Docking and Toxicity from Temulawak Rhizome (Curcuma xanthorrhiza Roxb.) against COX-2 Meilinda setya praceka; Ellen N. Yunita; Cleopatra D. Semesta; Refitha N. Putri; Nazwa N. Mikdar; Elsa N. Sitinjak; Luthfi U. Setyawati; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.43808

Temulawak rhizome (Curcuma xanthorrhiza Roxb.) is a rhizome that comes from the Zingiberaceaetribe. Temulawak rhizome is commonly used as a traditional medicine in Indonesia as an antiinflammatory.The purpose of this study was to provide information on the potential of temulawakrhizome as a COX-2 inhibitor drug candidate and its toxicity to shrimp larvae (Artemia salina Leach.).The methods used are Lipinski Rule of Five prediction, PreADMET, molecular docking, pharmacophorescreening, and BSLT toxicity test. The results obtained show that the lowest Gibbs energy is producedby curcumin (-9.65 kcal/mol), has a pharmacophore hit value, meets the Lipinski rule of five, predictsa good pharmacophore profile, but curcumin has mutagenic properties and is classified as toxic afterbeing tested. with the BSLT method. So that it can be concluded that curcumin has the potential tobecome an anti-inflammatory drug, but further studies are needed and modifications to the molecularstructure of the compound can be carried out so that the tested compound can produce better activity.

[REVIEW] METODE ANALISIS S-PHENYL MERCAPTURIC ACID (S-PMA) DALAM URIN SEBAGAI BIOMARKER PAPARAN BENZENA Sri Gustini Husein; Muchtaridi - -; Mulyana - -
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 5, No 2 (2016)
Publisher : Sekolah Tinggi Farmasi Indonesia

Abstraks-PhenylMercapturic Acid (s-PMA) merupakan salah satu biomarker spesifik yang diusulkan untuk pemantauan biologis terhadap paparan benzena dalam konsentrasi rendah. American Conference of Governmental Industrial Hygienists (ACGIH) juga mengharuskan perusahaan industri untuk mengevaluasi tingkat s-PMA pada pekerja yang bekerja terkait dengan benzena. ACGIH BEI (Biological Exposure Limit) menetapkan nilai normal s-PMA dalam urin maksimal 25 μg/g kreatinin (25 ppb) (ACGIH, 2012). Beberapa metode telah dikembangkan untuk mendapatkan kesesuaian prosedur dalam penetapan kadar s-PMA dalam urin. Metode yang digunakan untuk analisis s-PMA sampai saat ini adalah High Performance Liquid Chromatografi (HPLC) dengan detektor flouresens, HPLC dengan detektor DAD, HPLC-MS-MS, GC-MS, dan ELISA (Wang. Z, et al, 2013). Preparasi terhadap sampel dilakukan beberapa tahap, menggunakan teknik liquid-liquid extraction (LLE), solid-phase extraction (SPE) dan derivatisasi analit menjadi senyawa fluoresens terkonjugasi (Buratti M, 2001). Kata kunci: Biomarker, s-Phenyl MercapturicAcid (s-PMA), Benzena, HPLC Abstracts-PhenylMercapturic Acid (s-PMA) is one of the specific biomarkers purposed for biological monitoring of benzene exposure in low concentrations. The American Conference of Governmental Industrial Hygienists (ACGIH) also requires industrial companies to evaluate the level of s-PMA who workrs working with benzene. ACGIH BEI (Biological Exposure Limit) determines the normal value of s-PMA in urine to a maximum of 25 μg/g creatinine (25 ppb) (ACGIH, 2012). Several methods have been developed to obtain the suitability of procedures in the determination of s-PMA levels in the urine. The recently of analysis methods used for s-PMA are High Performance Liquid Chromatography (HPLC) with flouresens detector, HPLC with DAD detector, HPLC-MS-MS, GC-MS, and ELISA (Wang. Z, et al, 2013). Sample preparation was performed in several stages using liquid-liquid extraction (LLE), solid-phase extraction (SPE) and analytical derivatization into conjugated fluorescence (Buratti M, 2001). Keywords: Biomarker, s-Phenyl MercapturicAcid (s-PMA), Benzene, HPLC

Effects of Mangosteen Peel Extract Encapsulated By Maltodextrin On Antibacterial Activities of Escherichia coli Andri Kusmayadi; Lovita Adriani; Abun; Muchtaridi; Ujang Hidayat Tanuwiria
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): January - March
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.4627

Mangosteen peel extract contains good antibacterial compounds and is thought to be better when microencapsulated is formed. This study aimed to determine the effects of formulation of mangosteen peel ethanol extract associated to maltodextrin on activities of Escherichia coli. It was conducted by disk diffusion method according to Kirby-Bauer test in Mueller Hinton Agar (MHA) using three different concentrations namely: 100, 75, and 50 (%). Each formulation was tested as many as 10 µL disk -1 consisted of each treatment. The employed maltodextrin was obtained by enzymatic processing of arenga starch. Nine formulations were tested by measuring their bacterial inhibition activity in a Mueller Hinton Agar (MHA) medium. The results showed that the effects of formulation between mangosteen peel ethanol extract and maltodextrin had the significant effect (P<0.05) on the antibacterial activities of Escherichia coli. It had been shown the ability to actively inhibit the bacterial growth at medium levels.

Co-Authors A. A. Putri A. Diantini - A. Khalilah A. L. Triadenda A. Mutalib - Abdul Mutalib Abdul Mutalib Abednego K. Gwiharto Abednego Kristande Abun Abun Abun Abun Abun Ade Rizqi Ridwan Firdaus Ade Zuhrotun Agus Rusdin Agus Rusdin AJENG DIANTINI Aliya Nur Hasanah Ami Tjiraresmi Anas Subarnas Andri Kusmayadi Angga Geganaputra Annisa Atusholihah Annisa Rafashafly Anton Apriyantono Arief Cahyanto Arif Budiman Arif Budiman Asep Nurrahman Yulianto Basuki Hidayat C. Suhandi Carla Florencia Cecep Suhandi Cecep Suhandi Cecep Suhandi Christine Christine CINDY APRILLIANIE WIJAYA Cindy Aprillianie Wijaya Cleopatra D. Semesta Desra Widdy Syafra Devani Olivia Winardi Dewi Permatasari Diah Lia Aulifa Diantini, A. - Dilal Adlin Fadil Dini Rochdiani Dolih Gozali - E. Laelasari E. Novianti Eli Halimah Eli Halimah ELI HALIMAH Ellen N. Yunita Elsa N. Sitinjak Elvan Kamal Ersa Fadhilah F. Ardiansyah Fadil, Dilal Adlin FATHIA NABILA AULANI Fathia Pebriani Ganendra Akbar Hadiyanto Gia A. Faradiba Hafidh Beta Arif Putra Harsoning Tyas Mardisanutol Hasna Chaerunisa Herlina Herlina I Made Jhoni I Made Joni I. R. Hartanti Ida Ayumiati Ida Musfiroh Ida Musfiroh Ida Musfiroh - Imam Adi Wicaksono Ivanna Fauziyah Kusnadi Iyan Sopyan Jessica Tristi Jessyca Sirait Jutti Levita Karyadi Karyadi Karyn Elizabeth Keiichi Motoyama Kevin Reinard Lie L. Pangestu Levita, J. - Lovita Adriani Luthfi Ihsan Sulaeman Luthfi U Setyawati Luthfi U. Setyawati Luthfi Utami Setyawati Luthfi Utami Setyawati Maitsa Alya Fakhirah Martalena Ramli MEGANTARA, SANDRA Meilinda setya praceka MELISSA MELISSA Mentari Luthfika Dewi Mohamad Taufik Ismullah Monica Richelle Herdady Muhammad Ariq Al Faruq Muhammad Fadhil Pratomo Muhammad Raihan Riyaldi Muhammad Syahid Abdillah Muhammad Yusuf Mulyana - - Musfiroh, I. - Mustarichie, R. - Mutakin Mutakin N. Elly Rosilawati N. N. Auliya AS Nabila Alivia Yasmin Nabilah Muhamad Nadia Ulil Fatiya Nadya Dwi Banowati NAELI FARHATY Nasrul Wathoni Nathannael Adrya Hadiwijaya Nazwa N. Mikdar Neli Neli Nia Yuniarsih Norisca A. Putriana Norisca Aliza Putri Norisca Aliza Putri Nurfianti Silvia Nurhanifah Puspitadewi Nursuhud NUZAHA BAQIYATUS SHOLIHAH AZIMAH Petra Pahlawanda Chrisanto Liawardi Randy Rassi Prayoga Ratu Hanifa Fayza Dipadharma Refitha N. Putri Richa Mardianingrum Rina Fajri Nuwarda Risda R Islamiyati Risda Rahmi Islamiaty Riska Febriyanti Ronny Lesmana S. Hidayat Salsa Sagitasa Salsabila Athaya SANDRA MEGANTARA Sandra Megantara Savira Silma Aulia Shafa Nurul Fadilah Siti Nunung Nurulaini Sitti Faza Karima Slamet Budijanto Sri Adi Sumiwi Sri Aguswarini Sri Gustini Husein St. Rohmani Nahariyah Stepanus Massora Sugianto Ayudha Hartono Suhendi, Cece Susyati Susyati Syahla Afaaf Alliyah Syahrul Hidayat T. N. Apriliya Taofik Rusdiana TIANA MILANDA TIARA SALSABILA MAJID Udin. L.Z - Ujang Hidayat Tanuwiria W. Oktavelia Wa Ode Ida Fitriah WARID ALI QOSIM Wiwit Nurhidayah Yasmiwar Susilawati Yulianto, Asep Nurrahman Yuni Nurjanah Zelika Mega Ramadhania

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