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Dewa Putu Gede Purwa Samatra
Bagian Neurologi Fakultas Kedokteran Universitas Udayana/ Rumah Sakit Umum Pusat Sanglah Denpasar Bali
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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

 1 
INTERLEUKIN-1?, INTERLEUKIN-6, AND ANTAGONIST INTERLEUKIN-1RECEPTOR AS MEMORY IMPAIRMENT RISK FACTOR IN COMPLEX PARTIAL EPILEPSY Purwa-Samatra, D. P. G.; Sudewa-Djelantik, A. A. G.; Suastika, and K.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 1 (2013): IJBS Vol.7 No.1 January-June 2013
Publisher : Udayana University

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Abstract

Memory impairment is one of the most common adverse following epilepsy, particularly complex partial epilepsy. Cytokines physiologically play an important role in memory impairment by preventing long term potentiation process in hypocampus. Several literatures have mentioned that IL-1b, IL-6 and antagonist receptor IL-1Ra are crucial cytokines in complex partial epilepsy. This study aims to find out whether high level of IL-1b and IL-6 as well as low level of IL-1Ra might be risk factors of memory impairment in complex partial epilepsy patient. This was a case control study, enrolling 30 complex partial epilepsy patients with memory impairment as case group and 30 complex partial epilepsy patients without memory impairment as control group. In this study, it was obtained that the mean of IL-1? level in case group was significantly higher compared to the control (2.74 ± 4.36 vs. 0.42 ± 0.18 pg/ml, p = 0.007). The mean of IL-6 in case group was significantly higher compare to control (5.89 ± 6.32 vs. 2.34 ± 1.80 pg/ml, p = 0.006). The mean of IL-1Ra level of the case group was not significantly higher compared to the control (519.81 ± 262.64 vs. 413.28 ± 106.85, p = 0.767). By applying bivariate analysis, McNemar’s test, we observed that IL-1? with cut off point 0.63 pg/ml and OR = 70 is a risk factor of memory impairment in complex partial epilepsy indicated by p = 0.001. Similar result was also gained for IL-6 with cut off point 2.87 pg/ml and OR = 4.57 as a risk factor of memory impairment in complex partial epilepsy indicated by p = 0.007. Meanwhile, IL- 1Ra with cut off point 471 pg/ml and OR = 0.727 was not as a risk factor of memory impairment in complex partial epilepsy indicated by p = 0.573. It can be concluded that the high level of IL-1B and IL-6 were the risk factors of memory impairment in complex partial epilepsy patients. High level 1L-1B patient was 70 times higher risk of becoming memory impaired. High IL-6 patients will have the risk nearly 5 times higher. The low level of IL-1Ra does not as a risk factor in epilepsy patients for having the following memory impairment.
Co-Authors Agus Antara, Agus Anak Agung Ayu Meidiary Anak Agung Ayu Putri Laksmidewi Anak Agung Ayu Suryapraba Anak Agung Bagus Ngurah Nuartha Anak Agung Gede Sudewa Djelantik Asrul Sani Astari Arum Cendani Goller Bagus Komang Satriyasa Bagus Ngurah Mahasena Putra Awatara Bhaskoro Adi Widie Nugroho, Bhaskoro Adi Widie Candida Isabel Lopes Sam Devi, Gusti Ayu Putu Giti Livia Dewa Putu Wisnu Wardhana Dyah Esti Pranwengrum Fitratun Najizah Haditya, Yogi I Dewa Ayu Inten Dwi Primayanti I Dewa Putu Sutjana I Gusti Ayu Widianti I Gusti Ngurah Ketut Budiarsa I Ketut Suastika I Ketut Sumada I M. P. Kesanda, I M. P. I Made Krisna Dinata I Made Oka Adnyana I Nyoman Adi Putra I Nyoman Mangku Karmaya I Putu Eka Widyadharma I Putu Gede Adiatmika I Putu Gede Wikandikta I. A. A. Indrayani, I. A. A. Ida Ayu Sri Indrayani Ida Ayu Sri Wijayanti Indra Lesmana Ketut Widyastuti Kumara Tini Lely Setyawati Kurniawan Lim, Demetria Jesica Luh Ita Mahendrayani Luh Made Indah Sri Handari Adiputra Luh Putu Ratna Sundari M. Irfan Muhammad Irfan Muhammad Ruslan Nuryanto Mutiah Munawarah Nadya Bianca Ni Ketut Candra Wiratmi Ni Made Linawati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Putu Winda Apriyanti Ni Wayan Tianing Nitaya Putri Nur Hidayat Nuri Putri Ayu P, Sukarini Pristanova Larasanti Purna Putra IGN Putra IGN, Purna Putri Eka Pradnyaning Putu Agus Grantika, Putu Agus Putu Gede Sudira Putu Lohita Rahmawati Rizki Novrianti S. Indra Lesmana Sawitri, Anak Agung Sagung Sri Yenni Trisnawati Sugijanto - Sugijanto - Sugijanto Sugijanto Sukarini P Suryamulyawan, Kadek Adi Susy Purnawati Syahmirza Indra Lesmana TATI NURHAYATI Thomas Eko Purwata Tjokorda Gde Bagus Mahadewa Tri Wahyu Wulandari Trisa Permata Suhadi Trisha Anindya Trisha Indah Paramita Trisnawati, Sri Yenni Valentina Tjandra Dewi Valentina Tjandra Dewi Virny Dwiya Lestari Wahyuddin, Wahyuddin Wayan Westa Winda Haeriyoko Yusuf Nasirudin