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All Journal Farmaka Indonesian Journal of Applied Sciences Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) CHEMPUBLISH JOURNAL The Indonesian Biomedical Journal Jurnal Kimia Terapan Indonesia FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Jurnal Ilmiah Farmako Bahari Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Medical Sains : Jurnal Ilmiah Kefarmasian
Sri Adi Sumiwi
Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Binding Mode, Absorption, And Distribution Profile, Mutagenicity and Carcinogenicity of Asam Gelugur (Garcinia atroviridis Griff.) Fruit Phytoconstituents as Influenza H7N9 Neuraminidase Inhibitor Mohamad Taufik Ismullah; Sri Adi Sumiwi; Tiana Milanda; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 2, No. 2 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (613.267 KB) | DOI: 10.24198/ijpst.v1i2.21485

Abstract

The purpose of this study was to predict the bond mode, absorption and distribution profile as well as the mutagenicity and carcinogenicity of the asam gelugur fruit compounds which have the best inhibitory activity in neuraminidase influenza subtype H7N9 active pocket by in silico. Pharmacophore modeling and molecular docking using Ligandscout software. Absorption and distribution profiles using PreADMET software. Mutagenicity and carcinogenicity using Toxtree software. The results showed that 10 of the 13 compounds of asam gelugur fruit formed hydrogen bonds with important amino acid residues in the active sac neuraminidase H7N9. Organic acid group compounds have good absorption and distribution profiles. All acid gelugur fruit compounds are predicted not to be mutagenic and carcinogenic. Hydroxycitric acid is a compound that is predicted to have the best inhibition with the lowest Ki value of 1.09 µM. Hydroxycitric acid is a compound that is predicted to have the best inhibition with the lowest Ki value of 1.09 µM.Keywords: Neuraminidase Inhibitor, Influenza, H7N9, Hydroxycitric Acid
Co-Authors Ade Zuhrotun Ahmad Muhtadi Ai Hertati Ai Hertati, Ai Ajeng Diantini, Ajeng Aliya Nur Hasanah Ami Tjitraresmi Anas Subarnas Anni Anggraeni Anni Anggraeni, Anni Anni Aoggraeoi" Asman Sadino Clara Sunardi Clara Sunardi Clara Sunardi Dani Sujana Darwati Darwati Darwati Darwati Darwati, Darwati Deden Winda Suwandi DIANE FAUZI ELI HALIMAH Ellin Febrina Ellin Febrina FITRI NURJANAH Gofarana Wilar Hazna Putri Salsabilla Hendrayana, Jemmy Hendrayana, Jemmy Ida Musfiroh, Ida Iis Leniawati Indah Suasani Wahyuni Irma Erika Herawati Irma Melyani Puspitasari Irma Meylani Puspitasari Izzatul Khoirunnisa Jennifer Kolina Julisiana Sanggelorang Jutti Levita KHOIRINA NUR SA'IDAH Kirka Dwi Apriali Kolina, Jennifer Kusuma, Winny Lutfi Sulaiman MANUELA GLENATALIE PAKPAHAN Mardhiani, Yanni Dhiani Marline Abdassah Bratadiredja Marline Abdassah, Marline MEGANTARA, SANDRA Mochamad Rizal Moelyono, M W Moelyono, M W Mohamad Taufik Ismullah Muchtaridi Muchtaridi Mutakin Mutakin Mutakin Mutakin Mutakin Mutakin Nisa Masyitah NUR RAMADHANI MAUNG MANURUNG Nurike Susendi Nyi Mekar Saptarini Rahadianti Khofii Suwanditya Renny Amelia Riezki Amalia Rini Hendriani Rochjana, Anna Uswatun Hasanah Ronny Lesmana SAFIRA ANNISSA Sari Sumarni Siti Saleha Sriwidodo Sriwidodo Steffi Liem Supriyatna Supriyatna Taofik Rusdiana TIANA MILANDA Tina Rostinawati WAHYU EKA SAPUTRI Winny Kusuma Yasmiwar Susilawati Yoga Windhu Wardhana Yoppi Iskandar Yuli Andriani Yunita .