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All Journal Jurnal Kesehatan Andalas Berkala Ilmu Kesehatan Kulit dan Kelamin JURNAL PENGABDIAN KEPADA MASYARAKAT The Indonesian Biomedical Journal Collaborative Medical Journal (CMJ) Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Majalah Patologi Indonesia Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI)
Tofrizal
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Journal : The Indonesian Biomedical Journal

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Glutamine Supplementation Effects on Reducing Inflammation in The Ileum of Acute and Chronic Diarrhea Rats Induced by Enteropathogenic Escherichia coli Deddy Satriya Putra; Fadil Oenzil; Eryati Darwin; Hafni Bachtiar; Tofrizal Tofrizal
The Indonesian Biomedical Journal Vol 12, No 3 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i3.1124

Abstract

BACKGROUND: Glutamine, a non-essential amino acid, is the main fuel in the gastrointestinal mucosa. It is thought to protect the intestinal mucosa against local or systemic injury from diarrhea. This study aimed to determine the relationship between glutamine supplementation and ileum histopathology in acute and chronic diarrhea rats induced by enteropathogenic Escherichia coli (EPEC).METHODS: A randomized post-test only control group design was conducted. Thirty Rattus norvegicus Wistar strain were divided into 5 groups: one negative control group, two acute, and two chronic diarrhea groups. All four diarrhea groups were induced by EPEC at a dose of 108 CFU/mL. One acute and one chronic groups were supplemented with glutamine at a dose of 810 mg/200 g body weight for 14 days. While the other two diarrhea groups were not treated. The intestinal histopathology of each group was assessed and the level of inflammation was classified.RESULTS: Significant differences in inflammation levels were found among the groups (p<0.05). The highest inflammation level was observed in the acute diarrhea group without glutamine supplementation. Inflammation levels of both acute and chronic diarrhea with glutamine supplementation groups were significantly lower than the inflammation levels of acute and chronic diarrhea without glutamine supplementation groups.CONCLUSION: Supplementation of glutamine reduces the level of inflammation and leads to the histopathological improvement of the rat’s ileum.KEYWORDS: enteropathogenic Escherichia coli, glutamine, gastrointestinal tract, histopathology, ileum
Co-Authors Afdal Afdal Alvarino Alvarino Aswiyanti Asri Athika Rahmawati Deddy Satriya Putra Desmawati Desmawati Dwisari Dillasamola Endrinaldi Ennesta Asri Erkadius Erkadius Eryati Darwin Fadil Oenzil Fadillah Fadillah Fajriza Yona Fesdia Sari Hafni Bachtiar Intan, Shinta Ayu Lubis M Maliza, Rita Muhammad Idris Muhammad Nazri Janra Nofrita Nofrita Nur Afrinin Syah Putra Santoso R. Zuryati Nizar Rauza Sukma Rita Ria Oktavia Rifqoh Khotimah Rina Gustia Robby Jannatan Rusnita, Dewi RZ Nizar Salmiah Agus Salmiah Agus Salmiah Agus Selly Alinta Syukri Sisca Dwi Yarni Siti Nurhajjah SRI LESTARI Sri Lestari Suci Rahmadhani Sukri Rahman Yenita . Yenita Yenita Yenny Raflis Yessy Setiawati