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All Journal Jurnal Veteriner Media Kedokteran Hewan JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Medik Veteriner Darmabakti Cendekia: Journal of Community Service and Engagements Ovozoa: Journal of Animal Reproduction Journal of Applied Veterinary Science and Technology journal of Basic Medical Veterinary
Tri Wahyu Suprayogi
Department Of Veterinary Reproduction, Faculty Of Veterinary Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Journal : journal of Basic Medical Veterinary

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POTENSI KANDUNGAN ANTIOKSIDAN RUMPUT KEBAR (Biophytum Petersianum Klotzsch) TERHADAP APOPTOSIS DAN GAMBARAN HISTOPATOLOGIS TESTIS PADA MENCIT (MUS MUSCULUS) YANG DIPAPAR 2,3,7,8-Tetrachlorodibenzo-p-dioxin Dewita Dewita; Widjiati Widjiati; Rimayanti Rimayanti; Tri Wahyu Suprayogi; Mas'ud Hariadi; Hani Plumeriastuti
Journal of Basic Medical Veterinary Vol. 8 No. 1 (2019): Journal of Basic Medical Veterinary, June 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/.v8i1.19986

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most toxic compound in the dioxin group. This compound is a pollutant for the environment and very harmful to human health and enter the body through the mucous membranes in the mouth and the respiratory tract and can be transmitted through the placenta and lactation. The aim of this study was to know the antioxidantpotency of to resolve reproduction disturbance caused by TCDD exposure.Thirty Balb/C male mice were divided into five different groups, the negative control group, a positive control group exposed to TCDD at a dose of 7 μg/kg BW, P1 group of groups exposed to TCDD doses of 7 μg / kg BW and given Biophytum petersianum extract 0.05mg/gBB/day, group P2 group exposed to TCDD doses of 7μg/kgBW and given 0.080mg/gBB/day, and group P3 were exposed to TCDD dose of 7μg/kgBB and given the extract of Biophytum petersianum 0.135mg/gBB/day during day 2 to day 55. On the 56th day the mice were sacrificed and apoptotic examination and spermatogenic cell histopathological features were performed on the testis. The results showed that: P2 (0,433 ± 0,497; p<0,05) and P3 (0,200 ± 0,000 p<0,05) groups were the most effective group in decreasing spermatogenic cell apoptosis compared to positive control group (2,933 ± 1,5832 p<0,05). The Johnsen score result showed that P2 (9,400 ± 0,420) and P3 (9,800 ± 0,253) groups improving the histopathologic picture of spermatogenic cells in seminiferous tubules compared to positive control group (7,20 ± 0,400) p<0,05. Conclusion of this study were Biophytum petersianum is effective to solve reproduction disturbances caused by exposure of TCDD and the P3 group is the most effective group.
Co-Authors A.T Soelih Estoepangestie Abdul Samik Abdul Samik Abrian Panggalih Indra Pratama Agung Budianto Achmad Agus Sunarso Agus Widodo Alfiutha Propha Bhaskara Amung Logam Saputro Amung Logam Saputro Anwar Ma'ruf Arinda octavia Asih Deskayanti Astrid Annisya Adhy Putri Benjamin Chr. Tehupuring Bodhi Agustono Budi Utomo BUDI UTOMO Dadik Rahardjo Dewita Dewita Dinda Reisinta Djoko Legowo Dwi Novita Sari Erma - Safitri Erma Safitri Febby Fairy Brillianti Firman Setyawan Hana Eliyani Hani Plumeriastuti Herinda Pertiwi Herlina Masyitoh Hermin Ratnani Hermin Ratnani Herry Agoes Hermadi Himatul Oktavia I. Ismudiono Imam Mustofa Imam Mustofa Indah Norma Triana Indah Norma Triana Ismudiono Ismudiono Itrah Khoirunnisa Iwan Sahrial Hamid Kadek Rachmawati Kukuh Prastyaningtyas Kusnoto Kusnoto Lilik Maslachah Lilik Maslachah Linda Listyorini Linda Listyorini Lucia Tri Suwanti, Lucia Tri Mas'ud Hariadi Mas’ud Hariadi Mas’ud Hariadi Meles, Dewa Ketut Melsa Netika Mirza Asafaizh Arini Mufasirin Muhammad Ridwan Muhammad Ridwan Muhammad Thohawi Elziyad Purnama Muhammad Yunus Norma Amalia Ulfah Novia Nur Iskandari Oky Susandani Poedji Hastutiek Prima Ayu Wibawati Pudji Srianto Pudji Srianto R.T. Santanu Adikara Ragil Angga Prastiya Rahmi Sugihartuti Ratih Novita Praja Ratna Damayanti Restiadi, Tjuk Imam Retno Sri Wahjuni Ricko Nurdianto S. Rimayanti Rimayanti Rimayanti Rimayanti Rochmah Kurnijasanti Rochmi, Siti Eliana Roesno Darsono Sardjito, Trilas Sena Sangga Renata Sri Hidanah Sri Hidanah Sri Pantja Madyawati Sri Pantja Madyawati Suherni Susilowati Suherni Susilowati Sunaryo Hadi Warsito Syuhuud Arumbinang Wajdi Tantri Dyah Whidi Palupi Tatik Hernawati Tri Bhawono Dadi Trilas Sardjito Widjiati Widjiati Widya Aulia Ristiani Widya Paramita L Widya Paramita Lokapirnasari Wurlina w wurlina wurlina Yustisiane Ruth Rahadi