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All Journal Journal of Food and Pharmaceutical Science Jurnal Rekayasa Proses Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Pharmacon Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas (JFSK) Majalah Farmaseutik Jurnal Rekayasa Proses JFIOnline Media Farmasi Indonesia Media Farmasi Indonesia Jurnal Natural Aceh International Journal of Science and Technology Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy
Endang Lukitaningsih
Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : Jurnal Rekayasa Proses

 1 
Kinetics Study of Paracetamol Production from Para-Aminophenol and Acetic Anhydride Rifki Wahyu Kurnianto; Muhammad Fahrurrozi; Hilda Ismail; Raden Rara Endang Lukitaningsih; Indah Tri Nugraha; Pudjono Pudjono; Rochmadi Rochmadi; Ari Sudarmanto; Ratna Asmah Susidarti
Jurnal Rekayasa Proses Vol 15, No 1 (2021)
Publisher : Departemen Teknik Kimia Fakultas Teknik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jrekpros.64551

Abstract

In the last decade, Indonesia intensifies the efforts to reduce pharmaceutical imports. One of the initiatives is establishing a paracetamol production facility to start operating in 2024. Kinetics study is needed as a basis to design the paracetamol reactor. This study investigated the optimal temperature, reactant mole ratio, and agitation speed in the reactor for paracetamol production. In this study, aqueous solution of para-aminophenol was reacted with acetic anhydride. The mole ratio of para-aminophenol to acetic anhydride was varied to 1:1, 1:1.2, 1:1.5, and 1:2 while the temperature was varied to 80 °C, 90 °C, and 110 °C. However, due to uncontrolled heat of the reaction and limitation of the mixture’s boiling point, the actual reaction temperatures were 86 °C, 90 °C, and 108 °C. In addition, the agitation speed of 250 RPM and 350 RPM were also studied. Thin layer chromatography (TLC) and densitometry were used to determine the concentration of paracetamol in the reacting mixture. The optimum temperature, reactant mole ratio, and agitation speed in this study were 108 °C, 1:1.5, and 350 RPM, respectively. In addition, a reaction performed under those operating parameters gave the reaction rate constant of 1.95 L mol-1 min-1.Keywords: acetic anhydride; kinetics; para-aminophenol; paracetamol; pharmaceutical industry A B S T R A KDalam sepuluh tahun terakhir ini, Indonesia bertekad mengurangi impor bahan baku farmasi. Salah satu upaya yang dilakukan adalah membangun fasilitas produksi parasetamol yang akan mulai beroperasi pada tahun 2024. Studi kinetika diperlukan sebagai dasar perancangan reaktor parasetamol. Oleh karena itu, penelitian ini mengkaji kondisi operasi optimal pada reaksi produksi parasetamol yang akan dibutuhkan sebagai dasar perancangan pabrik. Pada percobaan ini, para-aminofenol direaksikan dengan anhidrida asetat dengan media air. Rasio mol para-aminofenol terhadap asetat anhidrida divariasikan 1:1 1:1,2, 1:1,5, dan 1:2 sedangkan temperatur divariasikan 80 °C, 90 °C, dan 110 °C. Akan tetapi, karena panas reaksi yang tidak dikontrol dan batasan berupa titik didih dari campuran reaksi, temperatur aktual reaksi menjadi 86 °C, 90 °C, dan 108 °C. Selain itu, kecepatan putaran pengadukan juga divariasikan pada angka 250 RPM dan 350 RPM. Kromatografi lapis tipis (KLT) dan densitometri digunakan untuk menentukan konsentrasi parasetamol dalam campuran reaksi. Temperatur, rasio mol reaktan, dan kecepatan putaran pengadukan yang optimum pada penelitian ini masing-masing adalah 110 °C, 1:1,5, dan 350 RPM. Selain itu, reaksi yang dilakukan dengan kondisi operasi tersebut menghasilkan konstanta laju reaksi 1,95 L mol-1 menit-1.Kata kunci: anhidrida asetat, industri farmasi, kinetika, para-aminofenol, parasetamol
Co-Authors -, Ariyanti -, Sutriyanto Abdul Rohman Abdul Rohman Aditya Wisnusaputra Aditya Wisnusaputra, Aditya Ag. Yuswanto Ag. Yuswanto Akhmad Kharis Nugroho Alfat Fadri Amalia Miranda Amanita K. Hana Andi Nur Aisyah Annisa Novarina Ardian Widyatmoko Argandita Meiftasari Ari Sudarmanto Ari Sudarmanto Arief Nurrochmad Ariyanti - B. S. Ari Sudarmanto Bustomi, Tomy Bustomi, Tomy Devyanto Hadi Triutomo Dirman, Arifin Dwi Hastutik Etty Sulistyowati Hilda Ismail, Hilda I Gede Agus Juniarka I Gede Agus Juniarka, I Gede Agus Ika Puspita Sari Ika Puspita Sari Ika Puspitasari Indah Purwantini Indah Tri Nugraha Irfan Muris Setiawan Khairunissa Irnanda Kurnianto, Rifki Wahyu La Ode Muhammad Andi Zulbayu Laeli Muntafi'ah Lina Primadesa, Lina Lisa Andina Lora Johana Tamba Lucky Octavianus Saputra M, Suwaldi Marwati Marwati Melania Perwitasari, Melania Meti Christiana Mufrod, . Mufrod, . Muhammad Bahi Muhammad Bahi Muhammad Fahrurrozi Mustanir Mustanir Mutia Kusuma Wardani Nanang Fakhrudin, Nanang Noegrohati, Sri Pudjono Pudjono Purwantiningsih Purwantiningsih Purwantiningsih Radilla Mutia Ragil S. Dianingati Rahmawati, Adillah Ratih Kurnia Wardani Ratna Asmah Susidarti Ratna Budhi Pebriana Revita Saputri Rochmadi Rochmadi Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Salsabila Yusfita Fawzy Samsul Hadi Samsul Hadi Sekar Ayu Pawestri Sekar Ayu Pawestri Siti Mufidatul Khasanah Sri Noegrohati Sri Noegrohati Standie Nagadi Subagus Wahyuono Subagus Wahyuono Sudarmanto, B.S. Ari Sudarmanto, Bambang Sulistyo Ari Sudibyo Martono Sugeng Riyanto Sugeng Riyanto Suwaldi M Suwaldi Martodihardjo Suwaldi Martodihardjo Syamsu Nur Syamsu Nur Ulrike Holzgrabe Widyasari Putranti Wirasti, Wirasti Wiwik Supriati