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All Journal Journal of Food and Pharmaceutical Science Jurnal Rekayasa Proses Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Pharmacon Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas (JFSK) Majalah Farmaseutik Jurnal Rekayasa Proses JFIOnline Media Farmasi Indonesia Media Farmasi Indonesia Jurnal Natural Aceh International Journal of Science and Technology Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy
Endang Lukitaningsih
Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : Indonesian Journal of Cancer Chemoprevention

 1 
Safety Evaluation of Chicken Satay In Yogyakarta Indonesia Based on Benzo[A]Pyrene Content Irnanda, Khairunissa; Meiftasari, Argandita; Nagadi, Standie; Lukitaningsih, Endang
Indonesian Journal of Cancer Chemoprevention Vol 3, No 3 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Chicken  satay  is  one  of  Indonesian  food  which  is  very  popular  and  processed  by direct  flame  over  the  meat.  But,  almost  every  types  of  food  which  are  prepared  by  direct flame  will  produce  chemical  compounds  that  contributes  to  the  incidence  of  cancer. Polycyclic aromatic hydrocarbons (PAH) is a group of compound which can cause cancer and is  resulted  from  the  incomplete  combustion  of  fossil  fuels  or  pyrolysis  of  organic  material containing  carbon  and  hydrogen  atoms.  One  PAH  compound  having  mutagenic  and  highly carcinogenic  effect  is  benzo[a]pyrene  which  is  the  highest  content  found  in  foods  that  are burned directly on the flame. This study aims to establish levels of benzo[a]pyrene contained in  chicken  satay  in  Yogyakarta,  Indonesia  and  to  evaluate  how  it  meets  with  the maximumbenzo[a]pyrene  limit  in  the  burned  food  based  on  National  Agency  of  Drug  and Food  Control  which  is  equal  to  5  ppb  (5  mg/kg).  Analysis  were  performed  by  Gas Chromatography  method  using  helium  as  carrier  gas  and  CPCB-Sil8  as  stationary  phase. After  the  sample  was  prepared  and  analysed  by  GC,  it  is  known  that  the  amount  of benzo[a]pyrene in chicken satay found in Yogyakarta are ranging from 2.5 to 393.32 ppb. The result are quite high and far  above the safety limit determined by  National Agency of Drug and Food Control.Therefore, the result of the research needs to be socialized to the public so that people can be more aware about the danger of food they consume.Keywords: chicken  satay,  benzo[a]pyrene  (BaP),  policyclic  aromatic  hidrocarbon  (PAH), carsinogen, Yogyakarta
SPF Test from Baccaurea lanceolata Muell.Arg Fruit Isolates Samsul Hadi; Subagus Wahyuono; Ag. Yuswanto; Endang Lukitaningsih
Indonesian Journal of Cancer Chemoprevention Vol 8, No 1 (2017)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev8iss1pp38-41

Abstract

Not many researches on a fruit of limpasu (Baccaurea lanceolata Muell. Arg ) were found, while the use by tribal hamlets in Kalimantan already became a daily routine before they went into the field with the way made powder and smeared on the face. Therefore, the research on active substances needs to be done. For this study, we prepared two isolates which coded as K2 and CE, K2 from qualitative test negative isolates phenolic groups was identified by spray FeCl3, whereas qualitative test positive isolates were coded as CE and detected by a nitrogen-containing reagents dragendorf spray. The K2 isolate from SPF test resulted an SPF value of 3.2 at a concentration of 0.2 mg/ml, while CE isolate was given a value of SPF 5.0 at a concentration of 0.2 mg/ml. According to sensitivity skin test on rabbit skin, both K2 and CE isolated were given the value below 1, indicated the isolates were found to not irritate. This study proposes the potential from Baccaurea lanceolata Muell.Arg fruit isolates to be developed as a sunscreen for UV-protection.Keywords : Baccaurea lanceolata Muell.Arg, SPF test, sensitivity skin test
The Combination of High Calcium Milk with Citrus maxima Peels Ethanolic Extract Increased Bone Density of Ovariectomized Rats Ragil S. Dianingati; Annisa Novarina; Amanita K. Hana; Laeli Muntafi'ah; Endang Lukitaningsih
Indonesian Journal of Cancer Chemoprevention Vol 6, No 2 (2015)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev6iss2pp42-48

Abstract

Osteoporosis is a common problem in menopause woman. The main cause is lack of estrogen hormone. Commonly, prevention therapy is by consuming high calcium milk, but it is not effective. Bali orange’s peel (Citrus maxima Merr.) is a waste material but known contains phytoestrogen according to previous study. Considering of this result, fortification of high calcium milk and Bali orange’s peel is expected to be an effective solution for osteoporosis in menopause woman. This research began with extraction of Bali orange’s peel (BPE) using ethanol 70% by maceration method. Ovariectomized Sprague Dawley female rats as the model of post menopausal woman were treated by BPE for 28 days. The doses of BPE was given to rats is 500 and 1000 mg/KgBW combined with high calcium milk. Bone density was determined using digital microradiography, the profile showed the increase of bone density in group that treated with combination of BPE 1000 mg/Kg BW and high calcium milk compare to control and given only milk groups. Docking molecular showed that BPE’s active compound which are hesperidin and naringin have interaction with estrogen receptor α and β. Docking score of naringin with ER α and β are -19,97; -18,99 respectively. Meanwhile the docking score of hesperidin with ER α and β are -19,98; +49,92 respectively. Overall, the result of this research showed that fortification of BPE with high calcium milk has good prospect to develop as effective therapy of osteoporosis.Keywords : Citrus maxima Merr., phytoestrogen, osteoporosis, high calcium milk, estrogen receptor 
Estrogenic Effect Ethanol Extract Corn Silk (Stigma maydis) on Bone Density and Histology Femur Profiles in Ovariectomized Rats Female Sprague Dawley Strain Devyanto Hadi Triutomo; Amalia Miranda; Lora Johana Tamba; Endang Lukitaningsih
Indonesian Journal of Cancer Chemoprevention Vol 7, No 3 (2016)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev7iss3pp104-109

Abstract

Osteoporosis in menopause woman is caused by estrogen deficiency which plays an important role in bone formation. Corn silk (Stigma Maydis) contains stigmasterol, a phytosterol compound predicted to act as phytoestrogen. The aim of this research is to observe the activity of Corn Silk as the source of phytoestrogen by in vivo study in ovariectomized rats. Bone density analysis was examined by using x-ray. Meanwhile, histological profile of bone matrix was determined by HE-staining microscopic observation. Affinity of stigmasterol to ER (α,β) were evaluated by molecular docking. The results showed that treatment of EECS after ovariectomy has not been able to increase bone density compared to the control group OVX. Moreover, histological observation of bone matrix showed that EECS performed improvement effect compared to was observed in the administration of estradiol. Docking between stigmasterol and ER (α,β) gave the docking score which are almost the same as that seen in docking with estradiol. In summary, EECS produced positive effects on bone density in estrogens-deficient OVX rats by reducing bone resorption. Therefore, EECS may also prove to be helpful in preventing osteoporosis in postmenopausal women whose estrogen is insufficient.Keywords: osteoporosis, phytoestrogen, corn silk, stigmasterol
The Exploration of Vetiver (Vetiveria zizanioides) as Co-Chemotherapy of Lung Cancer Selectively Targets AKR1C1: Bioinformatics Approach Lucky Octavianus Saputra; Salsabila Yusfita Fawzy; Ratih Kurnia Wardani; Endang Lukitaningsih
Indonesian Journal of Cancer Chemoprevention Vol 13, No 2 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss2pp114-127

Abstract

Reactive Oxygen Species (ROS) is one of the cancer-causing agents, one of which is lung cancer. In addition to being carcinogenic, ROS can also be used to kill cancer cells themselves, by increasing their levels to the threshold of apoptosis. Therefore, it is necessary to inhibit certain antioxidant enzymes that are highly expressed in lung cancer. One of them is AKR1C1 which plays a role in the eradication of intracellular ROS. However, AKR1C1 has a high structural similarity to AKR1C2, so it can inhibit therapy causing selectivity problems. Vetiver (Vetiveria zizanioides) has potential as an anticancer. This study was conducted to explore vetiver as a co-chemotherapeutic agent for lung cancer targeting AKR1C1 selectively. The method used is distillation, identification of vetiver compounds using GC-MS, and through bioinformatics studies. Predictive analysis with KNIME was carried out to determine the activity of the test compound. All tested vetiver compounds had a predictive value of 1 (active) on AKR1C1 and 0 (inactive) on AKR1C2. Through GC-MS obtained 354 compounds were identified. These compounds are used to filter the compounds predicted by KNIME. The molecular docking results showed that of the 10 tested vetiver compounds, there was 1 compound that had the strongest bond in interacting with AKR1C1, namely beta vetispirene compound with an S-score of -15.12 kcal/mol, and stronger than native ligand and aspirin. Based on the research data, it can be concluded that the beta vetispirene compound in vetiver can be a potential co-chemotherapy agent for lung cancer in targeting AKR1C1 selectively. However, further research is needed to prove its activity on lung cancer cells.Keywords: ROS (Reactive Oxygen Species), Lung Cancer, AKR1C1, selectivity, vetiver (Vetiveria zizanioides).
Co-Authors -, Ariyanti -, Sutriyanto Abdul Rohman Abdul Rohman Aditya Wisnusaputra Aditya Wisnusaputra, Aditya Ag. Yuswanto Ag. Yuswanto Akhmad Kharis Nugroho Alfat Fadri Amalia Miranda Amanita K. Hana Andi Nur Aisyah Annisa Novarina Ardian Widyatmoko Argandita Meiftasari Ari Sudarmanto Ari Sudarmanto Arief Nurrochmad Ariyanti - B. S. Ari Sudarmanto Bustomi, Tomy Bustomi, Tomy Devyanto Hadi Triutomo Dirman, Arifin Dwi Hastutik Etty Sulistyowati Hilda Ismail, Hilda I Gede Agus Juniarka I Gede Agus Juniarka, I Gede Agus Ika Puspita Sari Ika Puspita Sari Ika Puspitasari Indah Purwantini Indah Tri Nugraha Irfan Muris Setiawan Khairunissa Irnanda Kurnianto, Rifki Wahyu La Ode Muhammad Andi Zulbayu Laeli Muntafi'ah Lina Primadesa, Lina Lisa Andina Lora Johana Tamba Lucky Octavianus Saputra M, Suwaldi Marwati Marwati Melania Perwitasari, Melania Meti Christiana Mufrod, . Mufrod, . Muhammad Bahi Muhammad Bahi Muhammad Fahrurrozi Mustanir Mustanir Mutia Kusuma Wardani Nanang Fakhrudin, Nanang Noegrohati, Sri Pudjono Pudjono Purwantiningsih Purwantiningsih Purwantiningsih Radilla Mutia Ragil S. Dianingati Rahmawati, Adillah Ratih Kurnia Wardani Ratna Asmah Susidarti Ratna Budhi Pebriana Revita Saputri Rochmadi Rochmadi Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Rumiyati Salsabila Yusfita Fawzy Samsul Hadi Samsul Hadi Sekar Ayu Pawestri Sekar Ayu Pawestri Siti Mufidatul Khasanah Sri Noegrohati Sri Noegrohati Standie Nagadi Subagus Wahyuono Subagus Wahyuono Sudarmanto, B.S. Ari Sudarmanto, Bambang Sulistyo Ari Sudibyo Martono Sugeng Riyanto Sugeng Riyanto Suwaldi M Suwaldi Martodihardjo Suwaldi Martodihardjo Syamsu Nur Syamsu Nur Ulrike Holzgrabe Widyasari Putranti Wirasti, Wirasti Wiwik Supriati