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All Journal HAYATI Journal of Biosciences JURNAL KIMIA SAINS DAN APLIKASI Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Folia Medica Indonesiana Jurnal Kebidanan Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Universa Medicina Jurnal Fitofarmaka Indonesia Jurnal Kedokteran dan Kesehatan Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Molekul: Jurnal Ilmiah Kimia Majalah Kedokteran Andalas YARSI Medical Journal Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Teknik Kimia Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Conferences of Medical Sciences Dies Natalis
Subandrate
Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran Universitas Sriwijaya, Palembang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : Universa Medicina

 1 
Smoking tends to decrease glutathione and increase malondialdehyde levels in medical students Safyudin, Safyudin; Subandrate, Subandrate
Universa Medicina Vol 35, No 2 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.89-95

Abstract

BackgroundSmoking is the act of introducing toxic substances into the body. Cigarette smoke contains chemicals that may cause several disorders, including cardiovascular disease, cancer, and chronic obstructive pulmonary disease. Toxic substances in cigarette smoke have the potential to increase free radicals, malondialdehyde (MDA) levels and to decrease endogenous antioxidant (glutathione/GSH) levels. This study aims to determine the relationship of smoking with plasma GSH and MDA levels in medical students.MethodsThis study was analytical observational with cross-sectional approach. The study was conducted from April to December 2015. The subjects in this study were medical students, consisting of 20 smokers and 20 nonsmokers. Plasma GSH and MDA levels were determined biochemically using Sigma GSH Assay Kit and Sigma MDA Assay Kit. Data was analyzed using the independent t test. ResultsThe results showed that there was no significant difference between mean GSH in smokers (1.74 ± 0.91 mmol/L) and nonsmokers (2.42 ± 1.19 µmol/L) (p=0.441). Mean smokers MDA level of 2.06 ± 1.39 nmol/mL was not significantly different compared with mean nonsmokers MDA level (1.32 ± 0.90 nmol/mL) (p=0.092).ConclusionsSmoking tends to decrease plasma GSH levels and increase plasma MDA levels in medical students. Smoking history could be evidence of oxidative stress and an impaired oxidant defense system. In particular, young smokers should quit promptly before health problems arise, so as to have the optimal benefits of cessation.
Malondialdehyde levels are higher and glutathione levels are lower in preeclampsia than in normal pregnancies Subandrate, Subandrate; Faisal, Mia Esta Poetri Afdal; Anggraini, Nurul Windi; Sinulingga, Sadakata
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.179-186

Abstract

BackgroundMaternal mortality rate is still a health problem in Indonesia. One major contributor to maternal mortality rate in Indonesia is preeclampsia. One widely accepted theory is that preeclampsia is caused by oxidative stress. Placental hypoxia or ischemia among preeclampsia patients is thought to be the cause of the formation of free radicals such as malondialdehyde (MDA), which decreases endogenous antioxidants such as glutathione (GSH). This study aims to ascertain the difference in plasma malondialdehyde and glutathione levels between healthy and preeclamptic pregnant women.MethodsThis was an observational analytic study of cross sectional design. Research subjects were 30  normal (healthy) pregnant women (NP), and 30 pre-eclamptic pregnant (PE) women. The measurement of plasma MDA and GSH levels was done at the Biochemistry and Molecular Biology laboratories, Faculty of Medicine, Sriwijaya University using Sigma-Aldrich MDA and GSH assay kits. Mann Whitney test was used to analyze the data. ResultsSubjects aged >35 years, with age of gestation >35 weeks and multipara was significantly higher in the PE group compared to the NP group (p=0.016; p=0.01 and p=0.36; respectively). MDA level was significantly higher in the PE group than in the NP group (p=0.002). In contrast, GSH level was significantly lower in the PE group than in the NP group (p=0.003).ConclusionMDA and GSH may reflect vascular complications of PE, and the ensuing increases in lipid peroxidation may play important pathogenic roles.
Co-Authors Adiyatma Putra Mahardika Alexander Theo Yuda Salean Anggraini Tiara Septiyana Gunawan Aninditia, Fahira Aninditia, Fahira Annes C. Adma Aprilia Putri Arifin, Mutmainah Aulia Firdha Tariza Az Zahra, Fatihah Bebbi Arisya Kesumaputri Danang Bagus Untoro Dazakiah Dazakiah Dwi Indira Setyorini Dwi Indira Setyorini Dwirini Retno Gunarti Dzakiyah, Dzakiyah Dzakiyah, Dzakiyah Eka Febri Zulissetiana Ella Amalia Ella Amalia, Ella Ellla Amalia Erial Bahar Eva Syahriana Evlin Kohar Ezra Hans Soputra Fadel Fikri Suharto Fahira Aninditia Fahira Aninditia Faisal, Mia EPA Fatihah Az Zahra Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fifa Argentina Galuh Anggraini Hariyadi, Kusumo Hayati, Lusiya Hayati, Lusiya Hermansyah Hestiningsih, Tyas Iche Andriyani Liberty, Iche Andriyani Intan Rahma Dewi Irfannuddin Irfannuddin Irfannudin Irfannudin Irsan Saleh Kohar, Evlin Kohar, Evlin Kusumo Hariyadi Kusumo Hariyadi Kusumo Hariyadi Lathifah Nudhar Liniyanti D. Oswari Lusia Hayati M Fakhri Altiyan M Fitra Romadhon M. Dias A. Monanda M. Hafizh Arrafi M. Hafizh Arrafi M. Nadhif Prasetyo M. Nadhif Prasetyo Mariana Mariana Masayu Farah Diba Masayu Farah Diba Mediarty Mediarty Mediarty Medina Athiah Medina Athiah Medina Athiah Medina Athiah Melina Indah Sari Mgs Irsan Saleh Mgs. Irsan Saleh Mia EPA Faisal Mia Esta Poetri Afdal Faisal, Mia Esta Poetri Afdal Mohamad Sadikin MOHAMAD SADIKIN Muhammad Irsan Saleh Muniaty Sulam Ng Muthmainnah Arifin Mutia Muthmainnah Firdaus Mutiara Budi Azhar Naomi W Tioline Nur Azizah Nurul Windi Anggraini Nurul Windi Anggraini, Nurul Windi Oktalisa, Wenni Oswari, Liniyanti D Permono, Trijoso Putriana Fuji Safitri Raafqi Ranasasmita Rasyid, Riana Sari Puspita Ray Suga Aulia Rini Yana Rini Yana Rini Yana Rizki Andini Nawawi Sadakata Sinulingga Sadakata Sinulingga Sadakata Sinulingga Safyudin Safyudin Safyudin Safyudin Safyudin Salni Salni Salni Salni Salni Salni Setyorini, Dwi Indira Soputra, Ezra Hans Soputra, Ezra Hans Sri Hartini Harianja Sri Nita Sri Nita Sri Nita, Sri Sri Wahyuni Suly Auline Rusminan Susilawati Susilawati Susilawati Susilawati Tri Suciati Trijoso Permono Trijoso Permono Triwani Triwani Untoro, Danang Bagus Untoro, Danang Bagus Zen Hafy