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Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran Universitas Sriwijaya, Palembang, Indonesia
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Journal : Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

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EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN BENALU KERSEN (Dendrophthoe pentandra (L.) Miq) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN Adiyatma Putra Mahardika; Sadakata Sinulingga; Medina Athiah; Subandrate Subandrate
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.522 KB) | DOI: 10.36387/jiis.v6i2.659

Abstract

This study aims to determine the effect of lowering blood glucose. The study was conducted in an experimental laboratory in vivo with one group randomized prepost-test design. The extract was made through the gradual maceration process of Benalu Kersen leaf simplicia with ethanol solvent. The extract was divided into three groups with doses of 65 mg / kg, 130 mg / kg, and 260 mg / kg of body weight. The sample used was 9 male white rats (Rattus norvegicus) which were randomly divided into three groups. Blood glucose levels were measured before induction, after induction, after 7 days, and after 14 days of giving the extract. Data analysis was performed in the form of homogeneity test, normality test, paired t-test using Excel and SPSS programs. There was significant decrease in blood glucose levels on day 0 to day 7 in dose II group. The largest percentage reduction in blood glucose levels was shown in dose II group, namely 32.6%, followed by dose I group at 18.89%. The ethanol extract of Benalu kersen leaves did have an effect of lowering blood glucose levels on alloxan-induced male white rats.
Co-Authors Adiyatma Putra Mahardika Alexander Theo Yuda Salean Anggraini Tiara Septiyana Gunawan Aninditia, Fahira Aninditia, Fahira Annes C. Adma Aprilia Putri Arifin, Mutmainah Aulia Firdha Tariza Az Zahra, Fatihah Bebbi Arisya Kesumaputri Danang Bagus Untoro Dazakiah Dazakiah Dwi Indira Setyorini Dwi Indira Setyorini Dwirini Retno Gunarti Dzakiyah, Dzakiyah Dzakiyah, Dzakiyah Eka Febri Zulissetiana Ella Amalia Ella Amalia, Ella Ellla Amalia Erial Bahar Eva Syahriana Evlin Kohar Ezra Hans Soputra Fadel Fikri Suharto Fahira Aninditia Fahira Aninditia Faisal, Mia EPA Fatihah Az Zahra Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fifa Argentina Galuh Anggraini Hariyadi, Kusumo Hayati, Lusiya Hayati, Lusiya Hermansyah Hestiningsih, Tyas Iche Andriyani Liberty, Iche Andriyani Intan Rahma Dewi Irfannuddin Irfannuddin Irfannudin Irfannudin Irsan Saleh Kohar, Evlin Kohar, Evlin Kusumo Hariyadi Kusumo Hariyadi Kusumo Hariyadi Lathifah Nudhar Liniyanti D. Oswari Lusia Hayati M Fakhri Altiyan M Fitra Romadhon M. Dias A. Monanda M. Hafizh Arrafi M. Hafizh Arrafi M. Nadhif Prasetyo M. Nadhif Prasetyo Mariana Mariana Masayu Farah Diba Masayu Farah Diba Mediarty Mediarty Mediarty Medina Athiah Medina Athiah Medina Athiah Medina Athiah Melina Indah Sari Mgs Irsan Saleh Mgs. Irsan Saleh Mia EPA Faisal Mia Esta Poetri Afdal Faisal, Mia Esta Poetri Afdal Mohamad Sadikin MOHAMAD SADIKIN Muhammad Irsan Saleh Muniaty Sulam Ng Muthmainnah Arifin Mutia Muthmainnah Firdaus Mutiara Budi Azhar Naomi W Tioline Nur Azizah Nurul Windi Anggraini Nurul Windi Anggraini, Nurul Windi Oktalisa, Wenni Oswari, Liniyanti D Permono, Trijoso Putriana Fuji Safitri Raafqi Ranasasmita Rasyid, Riana Sari Puspita Ray Suga Aulia Rini Yana Rini Yana Rini Yana Rizki Andini Nawawi Sadakata Sinulingga Sadakata Sinulingga Sadakata Sinulingga Safyudin Safyudin Safyudin Safyudin Safyudin Salni Salni Salni Salni Salni Salni Setyorini, Dwi Indira Soputra, Ezra Hans Soputra, Ezra Hans Sri Hartini Harianja Sri Nita Sri Nita Sri Nita, Sri Sri Wahyuni Suly Auline Rusminan Susilawati Susilawati Susilawati Susilawati Tri Suciati Trijoso Permono Trijoso Permono Triwani Triwani Untoro, Danang Bagus Untoro, Danang Bagus Zen Hafy