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Polymorphism of Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Genes among Pregnant Women with Falciparum Malaria in Banjar District, South Kalimantan Province, Indonesia Fitriah Fitriah; Sriwijayanti Sulistyawati; Sugeng Riyanto; Budiono Budiono; Sukmawati Basuki; Yoes P Dachlan; Haruki Uemura
Journal of Tropical Life Science Vol. 2 No. 3 (2012)
Publisher : Journal of Tropical Life Science

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Abstract

Pregnant women are highly vulnerable to malaria infection in its endemic areas, particularly infection by Plasmodium falciparum that can cause premature, low birth weight, severe anemia in pregnant women, and death. Sulfadoxine-pyrimethamine (SP) for Intermittent Preventive Treatment for pregnant (IPTp) is used for malaria control in pregnancy recommended by the World Health Organization that has already been implemented in Africa. The P. falciparum resistance to SP has been reported in several malarial endemic areas, and mutations in the genes of Plasmodium falciparum Dihydrofolate Reductase (Pfdhfr) and Dihydropteroate Synthase (Pfdhps) are shown to be associated with parasite resistance to SP treatment. Genetic analysis of Pfdhfr and Pfdhps genes in pregnant women infected with P. falciparum has not yet been examined in Indonesia. The cross-sectional study was conducted at two subdistricts, Sungai Pinang and Peramasan, in Banjar district of South Kalimantan Province, where 127 pregnant women were recruited from 2008 to April 2010. Two important mutations in Pfdhfr gene (amino acid positions at N51 and S108) and three in Pfdhps gene (A437, K540 and A581) were analyzed by nested PCR-RFLP method. All of the seven pregnant women samples infected with P. falciparum presented PfDHFR 108N and PfDHPS 437G mutations. One of the samples had the additional mutation at PfDHPS 540, in which Lys is substituted by Glu. These results suggested that P. falciparum might present only some resistance to SP at Sungai Pinang and Peramasan subdistricts, Banjar District, South Kalimantan province, Indonesia. Although there were limited number of samples, this study showed only few mutations of Pfdhfr and Pfdhps genes in P. falciparum at Banjar district, South Kalimantan Province, that suggests SP might be effective for IPTp in this area. Thus, further analysis of the other mutation sites in Pfdhfr and Pfdhps genes and in vivo efficacy study of SP with more sufficient sample numbers will be necessary to confirm this preliminarily result.Keywords: PfDHFR and PfDHPS genes, Pregnant women, Falciparum malaria
MENYIKAPI PERGESERAN MINAT PENDIDIKAN ISLAM TINGKAT DASAR DENGAN MODERASI BERAGAMA Budiono Budiono
PARADIGMA : Jurnal Kajian Pendidikan Vol 15 No 01 (2023): April
Publisher : LP3M STAI MA'ARIF MAGETAN

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Abstract

The shift in the paradigm of society to send their children to public elementary schools is caused by the implementation of religious education which is considered lacking by the community. Meanwhile, the community really needs a larger portion of religious education for their children. Along with this need, MIN/SDI is present in the community by offering more and more balanced hours of religious education. This then gives more interest to the community to send their children to MIN/SDI. So that their need for a balanced education between general science and religion can be fulfilled with religious education institutions added religious moderation as a perspective in the millennial century.
Analisis Pengaruh Current Ratio dan Net Profit Margin terhadap Harga Saham Pada Perusahaan Jasa Sub Sektor Perdagangan Besar (Grosir) Dimasa Pandemi Covid-19 Periode 2020-2021 (Studi Kasus pada Bursa Efek Indonesia) Aprilia Wulan; Budiono Budiono; Dwi Puji Rahayu Rahayu; Indrian Supheni; Wina Aprilia Purnamasari
Jurnal Literasi Akuntansi Vol 3 No 2 (2023): Juni 2023
Publisher : Yayasan Literasi Ilmiah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55587/jla.v3i2.65

Abstract

This study aims to determine the effect of the current ratio and net profit margin on stock pricescarried out by large (wholesale) sub-sector trading service companies listed on the Indonesia StockExchange. The population of this study is a large trading sub-sector (wholesale) service companylisted on the IDX in 2020-2021. The sample was determined based on the purposive sampling method,as many as 110 companies.The method used in this study is a quantitative method. This method is used to predict the influencebetween one variable and another, in this study, the variables X1 (Current Ratio) and X2 (Net ProfitMargin) are the dependent variable (free) and the Y variable (Stock Price) is the independent variable(bound). ), the instrument used is secondary data and simple regression analysis is used to analyzethe data.The results in this study are the variable Current Ratio (CR) has a negative and significant effect onstock prices, Net Profit Margin (NPM) has a positive and significant effect on stock prices. CurrentRatio (CR) and Net Profit Margin (NPM) together have a significant effect on stock prices. The studyshows that the current ratio has a negative and significant effect on stock prices, net profit marginshave a positive effect on stock prices.
EFFECT OF CUCUMBER (CUCUMIS SATIVUS) JUICE ON LOWERING BLOOD PRESSURE IN ELDERLY Pertami, Sumirah Budi; Rahayu, Dian Yuniar Syanti; Budiono, Budiono
Public Health of Indonesia Vol. 3 No. 1 (2017): January - March
Publisher : YCAB Publisher & IAKMI SULTRA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.82 KB) | DOI: 10.36685/phi.v3i1.93

Abstract

Background: Hypertension is one of the diseases that cause high morbidity. The use of modern hypertension medical treatment may cause a side effect, so cucumber as one of traditional medicines may become a choice.Objective: This study aims to see the effect of cucumber (Cucumis sativus) juice on lowering blood pressure in elderly at working area of Puskesmas (public health center) of Abeli, Kendari, 2015.Methods: This was a pre-experiment study with one group pretest-posttest design. Twenty elderly > 60 years old were selected by simple random sampling.Results: The result showed that there was a significant effect of cucumber juice on lowering blood pressure in elderly people at working area of Puskesmas of Abele, with t test for systolic blood pressure showed that t count > t table (7.095>2.093) or P-value is 0.000 < 0.05; and t test for diastolic blood pressure showed that t count > t table (6.190>2,093) or P-value is 0.000 < 0.05.Conclusion: The significant effect of cucumber (Cucumis sativus) juice on lowering blood pressure in elderly suggested that health professional might need to have the cucumber to deal with hypertension. However, further study is needed to examine the effect.
THE EFFECT OF PURSED LIPS BREATHING IN INCREASING OXYGEN SATURATION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN INTERNAL WARD 2 OF THE GENERAL HOSPITAL OF DR. R. SOEDARSONO PASURUAN Budiono, Budiono; Mustayah, Mustayah; Aindrianingsih, Aindrianingsih
Public Health of Indonesia Vol. 3 No. 3 (2017): July - September
Publisher : YCAB Publisher & IAKMI SULTRA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.089 KB) | DOI: 10.36685/phi.v3i3.132

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Background: Chronic obstructive pulmonary disease is a leading cause of death and disability. Thus, the effort to reduce the symptoms, such as dyspnea is necessity. Pursed lip breathing is assumed increasing oxygen saturation.Objective: This study aims to determine the effect of pursed lips breathing in increasing oxygen saturation in patients with COPD in internal ward 2 of the General Hospital of Dr. R. Soedarsono Pasuruan on May 16 - June 30, 2017.Methods: This was a pre-experimental design with pre-posttest design. There were 24 patients with COPD selected using simple random sampling technique. Pulse oximetry (oximeter pulse fingertip) was used to measure oxygen saturation. Data were analyzed using Wilcoxon Sign Rank Test.Results: Findings showed p-value 0.000 (<0.05), which indicated that there was a statistically significant difference in oxygen saturation before and after pursed lips breathing.Conclusion: There was a significant effect of pursed lips breathing on oxygen saturation in patients with COPD in the internal ward 2 of the general hospital of Dr. R. Soedarsono Pasuruan. Thus, pursed lips breathing could be applied as a nursing intervention in patients with COPD.
Penyegaran Kompetensi Guru dalam Perancangan Media Pembelajaran Interaktif Menggunakan Aplikasi Articulate Storyline 3 Rose Fitria Lutfiana; Budiono Budiono; Candra Rahma Wijaya Putra
GERVASI: Jurnal Pengabdian kepada Masyarakat Vol. 7 No. 2 (2023): GERVASI: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM IKIP PGRI Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31571/gervasi.v7i2.5464

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Kegiatan Pengabdian kepada Masyarakat (PkM) dilakukan di MA Muhammadiyah Malang yang didasari masih terbatasnya guru dalam memperoleh pengetahuan dan pelatihan terkait dengan media pembelajaran. Tujuan dari kegiatan PkM ini adalah meningkatkan kompetensi pedagogi guru untuk merancang dan mengimplementasikan media pembelajaran yang menarik dan interaktif sehingga diharapkan tercipta kegiatan pembelajaran yang efektif dan efisien. Peserta dalam kegiatan ini adalah guru-guru di MA Muhammadiyah 1 Malang yang berjumlah 10 orang. Metode pengabdian yang digunakan berupa focus group discussion, pelatihan dan pendampingan serta monitoring dan evaluasi. Untuk mengukur kemampuan guru dalam merancang media pembelajaran yang kreatif dan inovatif dilakukan dengan menggunakan angket. Hasil pre-test diperoleh rata-rata 74,8% sedangkan hasil posttest diperoleh rata-rata 90,2%, sehingga terjadi peningkatan sebesar 15% dengan tingkat ketercapaian sebesar 100%. Selain itu guru juga bisa membuat media articulate storyline 3 dengan sangat baik.
PENGARUH TERAPI TOTOK PUNGGUNG TERHADAP TEKANAN DARAH, NYERI KEPALA, KUALITAS TIDUR, KADAR GLUKOSA DARAH DAN KOLESTEROL PADA LANSIA PENDERITA HIPERTENSI Budiono Budiono; Sumirah Budi Pertami
Jurnal Keperawatan Terapan Vol 8 No 2 (2022): Jurnal Keperawatan Terapan (E-Journal)
Publisher : Poltekkes Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/joan.v8i2.3636

Abstract

Hypertension in the elderly is often caused by a degenerative process in the arteries, the blood vessels become stiff so that peripheral resistance increases as a result of increased blood pressure/hypertension causing various problems in the elderly. Full-blooded back is one type of complementary therapy that is useful for blood circulation and provides a relaxing effect, by stimulating the release of endorphins, cortisol, this hormone can provide a calm/relaxing effect and vasodilation occurs in blood vessels resulting in a decrease in blood pressure. blood pressure, headaches, sleep quality, blood glucose and cholesterol levels in the elderly with hypertension. This research method is pre-experimental with one group pre-post test design. The sampling technique used accidental sampling with a sample size of 30. The results of the statistical analysis of the Wilcoxon sign rank test, obtained a p-value of 0.001 for blood pressure, headache, sleep quality and cholesterol levels (LDL), while for glucose levels p-value: 0.018 then H0 is rejected, meaning that there is an effect of full-blooded therapy on blood pressure, headaches, sleep quality, blood glucose and cholesterol (LDL) levels in elderly people with hypertension.
PENGARUH KOMBINASI DIAPHRAGMATIC BREATHING EXERCISE DAN GUIDED IMAGERY TERHADAP PERUBAHAN TEKANAN DARAH PADA PASIEN HIPERTENSI DI RUANG INTERNA I RSUD DR. R. SOEDARSONO KOTA PASURUAN Sita Hendrakusuma Samsu; budiono budiono; mustayah mustayah
Jurnal Keperawatan Terapan Vol 5 No 2 (2019): Jurnal Keperawatan Terapan (e-journal)
Publisher : Poltekkes Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/jkt.v5i2.1015

Abstract

Hypertension is a disease of the cardiovascular system characterized by abnormal blood pressure above 140-90 mmHg. Efforts to reduce blood pressure can be done with non-pharmacological and pharmacological therapy. One of non-pharmacological therapy is a combination of diaphragmatic breathing exercise and guided imagery. The aim of this research was to study a combination of diaphragmatic breathing exercise and guided imagery of changes in blood pressure in hypertensive patients. The research design used is Quasy Experimental with the type of Pre-Post test Control Group Design. The large sample taken was 28 respondents with purposive sampling technique. This study uses the Shapiro-Wilk normality test which shows p-value less than 0.05 so that data distribution is not normal. Furthermore, the analysis of differences using Wilcoxon showed a decrease in blood pressure in the experiment and control group. Although the Mann-Whitney test did not show differences between the experiment and control group, clinically there was a combination of diaphragmatic breathing exercise and guided imagery to decrease blood pressure, as evidenced by the p-value of systolic 0.001 less than p-value diastolic which is 0.007. The combination of diaphragmatic breathing exercise and guided imagery is expected to be an alternative therapy for lowering blood pressure in hypertension. Keywords: Diaphragmatic Breathing Exercise and Guided Imagery, Hypertension
Analisis Kemiskinan Multidimensi dan Ketahanan Pangan Provinsi Kalimantan Utara Ainistikmalia, Nurin; Kharisma, Bayu; Budiono, Budiono
Jurnal Ekonomi dan Pembangunan Indonesia Vol. 22, No. 1
Publisher : UI Scholars Hub

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Abstract

Poverty is multidimensional and has a close relationship with food insecurity. By using the Alkire-Foster MPI with four dimensions (monetary, health, education, basic infrastructure), it was found that the monetary dimension has a role and contributes to multidimensional poverty although it’s not the main factor. The causes of poverty are obtained from other dominant dimensions. Meanwhile, the portrait of household food security in North Kalimantan Province in aggregate has been classified into food security category. It is concluded that poverty affects food security. This study proves that multidimensional poor households are very likely to become food insecurity households.
Co-Authors Abd. Syakur Agus Frianto Agus Tinus Aindrianingsih, Aindrianingsih Ainistikmalia, Nurin Alif Tiwi Estriyanti Alpha Fardah Athiyyah Amalia, Firdha Anang Kistyanto Andre Dwijanto Witjaksono Anisya Fitri Aprilia Wulan Asri Wijayanti AYU WULANDARI Badu’l Mat Saleh Baksono Winardi Bayu Kharisma Brahmana Askandar Tjokroprawiro Candra Rahma Wijaya Putra Dachlan, Yoes P Dewi Ayu Lestari Dewi, Gita Kusuma Diyah Fatmasari Diyah Putri Permata Djoko Sutikno Dominicus Husada Dwi Puji Rahayu Rahayu Endang Susilaningsih ERI PERDANA USHAN Faizah Yunianti Fitriah Fitriah Fitriah Fitriah Hafid Kholidi Hadi Haruki Uemura I Gusti Made Reza Gunadi Ranu I Gusti Made Reza Gunadi Ranuh Ika Rahmania Indrian Supheni Islamiyah, Wardah Rahmatul IWayan Sarjana Januardi, Dicky Jayanti, Lira Wiet Jun Surjanti Khoirunnisa, Nabila Farah Liesnaningsih Liesnaningsih M Y. Probohoesodo Muhammad Faizi Mustayah ., Mustayah Mustayah Mustayah Ngestreini, Rahmadani Nadya Nikie Astorina Yunita Dewanti Octavia, Dini Hariani Pertami, Sumirah Budi Pertami, Sumirah Budi Rachman Iswanto Raden Bagus Yanuar Renaldy Rahayu, Dian Yuniar Syanti Ratna Feti Wulandari Risky Dwiprabowo Ristya Sylva Imannia Rohmat Taufiq Rose Fitria Lutfiana ROSSYANTI, LYNDA Shalima, Irsyadi Sidarti Soehita Siswanto Darmadi Sita Hendrakusuma Samsu Siti Fatimah Soenaryo Siti Wahyu Wulandari Slamet Wahyudi Soraya Salle Pasulu Sriwijayanti Sulistyawati Sugeng Riyanto Sugeng Riyanto Sugeng Sutiarso Sukmawati Basuki Sulistyawati, Sriwijayanti Suwarsono Suwarsono Syarifuddin Dahlan Tony Seno Aji Uemura, Haruki Umu Nur Latifah Vide Bahtera Dinastiti Vinzy Yulina Widiana, Putri Wina Aprilia Purnamasari Wolayan, Grahana Ade Candra Yoes P Dachlan Yuyun Isbanah Zahra, Farah Az Zukhaila Salma