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NURUL HIDAYAH
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Journal : Pharmaciana: Jurnal Kefarmasian

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P53 expression in ischemic rat models after the administration of ketamine and ketamine-xylazine Ety Sari Handayani; Zainuri Sabta Nugraha; Kuswati Kuswati; Muhammad Yusuf Hisyam; Untung Widodo; Nurul Hidayah; Sahdella Sahdella; Wimpy Wimpy
Pharmaciana Vol 10, No 1 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.017 KB) | DOI: 10.12928/pharmaciana.v10i1.13451

Abstract

Ketamine and ketamine-xylazine are often used as anesthetic drugs in animal models of ischemia. However, their neuroprotective and neurotoxic effects in ischemic animal models that have undergone tBCCAO are still under debate. The protein p53 is a pro-apoptotic factor involved in the cellular mechanism of ischemia. The interaction between death-associated protein kinase 1 (DAPK 1) and p53 is fundamental in determining whether cells experience necrosis or apoptosis in an ischemic stroke. This study was purposed to identify the presence or absence of differences between the p53 expressions in the brains of tBCCAO-induced ischemic rat models after the administration of ketamine and ketamine-xylazine. It employed a post-test control group design with four groups of adult male Wistar rats as the subject: (1) sham group operated with ketamine, (2) sham group operated with ketamine-xylazine, (3) models of tBCCAO-induced ischemia with ketamine, and (4) models of tBCCAO-induced ischemia with ketamine-xylazine. Ketamine was administered at the dose of 75mg/kg BW, while xylazine was at 8 mg/kg BW. The expression of p53 in rat brains was assessed by semi-quantification, specifically IHC staining with anti-p53 antibodies. P53 expression appeared as brownish stains in the cytoplasm of forebrain pyramidal neurons, and in this study, it was measured using the Allred score. The ANOVA test yielded a p-value of >0.05, implying the absence of difference between the p53 expressions in the brains of tBCCAO-induced ischemic rat models receiving ketamine and ketamine-xylazine.
Co-Authors Afi Rachmat Slamet Agus Setyo Utomo Agus Slamet Haryanto Ahmad Humam Hamid Aji Hermawan Ali Daud Hasibuan Almira Rahmatika Amriani Sapra Amy Nindia Carabelly, Amy Nindia Anak Agung Ketut Sudharmawan Andar Luki Faryanto Andhika Hayyu Pratama Andika Bagus Nur Rahma Putra, Andika Bagus Nur Rahma Angga Irawan Anis Nur Widayati Anisa Mulyani Anita agustina Anita Dwi Rahmawati Annasari Mustofa Apriani Ardyan Firdausi Mustoffa Arief Noviarakhman Zagladi Asti Kusuma Wardani Baiq Mira Aulia Salsabila Barra Gusma Fadillah Casminto Casminto Choiril Hana Mustofa Danang Aria Nugroho Darini Kurniawati Devi Safitri Didik Indarwanta Diki Cahyo Ramadhan Dinda Ariyantika Dindin Wahyudin Dini Yuniarti Diniyah Kholidah Djajadi Djajadi Dona Santika Doni Teguh Wibowo Dwi Indah Dwin Seprian Edy Yusuf Agung Gunanto Ega Asnatasia Maharani ELLY SUSANTI Emily Nur Saidy Nur Saidy Eti Herawati Ety Sari Handayani F, Feliatra Fabelyn Gandryal Mistipa Fahruddin Kurdi Fajar Yousriatin Fitri Oviyanti Florensa Florensa Fransisca Tassia Fuadah Fakhruddina Hamidah Hamidah Hans Julio Pratama Harapan Parlindungan Ringoringo Hasni Yaturramadhan Harahap Hayani Anastasia Hindarto Huldani Huldani Ibrahim Ibrahim Ika Ratna Indra Astutik Indro Herry Mulyanto Intan Nur ‘Ain Intan Tolistiawaty Ira Rahmawati Irwandani Irwandani Isniyatun Niswah Muflikhatuz Kamaliah - Karkono Karkono Kartika Chrysti Suryandari Khairani Khairani Kholis, Anja Hesnia Kuswati, Kuswati Laksono Trisnantoro Lalu Ali Wardana Lingling Marinda Palupi Lintang Sari Listi Oktaviani Ludfi Muyassaroh M. Ainul Rizki Setiawan Made Agus Nurjana Maharagita Audimy Tammalea mahmud Junianto Mari Okatini Mariaty Ibrahim Masmuri Masmuri Maya Fitriasari Meti Maspupah Mohammad Suryawinata Muh. Nazri Muhammad Fakhri Ardyansyah Muhammad Hatta Subakti Muhammad Hufron Muhammad Junaidi Muhammad Yusuf Hisyam Murniati Murni Nadia Rahmawati Nadia Rizky Amalia Ni Nyoman Veridiana Nisma Nissa Tarnoto Nurhalifah Nuri Fadhilah Nurmiati, Nurmiati Nurul Annisa Nur’azizah Octaviani Mesatoding Panghiyangani, Roselina Puput Haryani Putri Amanda Radhia Riski Rahmayanti Hasibuan Rahmiati Rahmiati Reksa Rohmadona Renaldi Sutomo Renie Kumala Dewi Riris Wahyu Satyaningtyas Riza Arifin Robby Hudiansyah Romlah Romlah Rudi Hamarno Poltekkes Sahdella Sahdella Sapta Raharja Prayoga Suryadarma dan T. Ikhsan Azmi Ani Suryani Selasih Selasih Selvi Damayanti Septina Laylatu Zahro Shofia Rahmi Shofia Rahmi Shofiyah Al Idrus Siti Arfah Siti Rahma Yanti Siti Rifani Siti Suleman Sitti Chadijah Sugeng Heri Suseno Sujono - Suryo Nugroho Syarifah Syarifah Tika Fitriyah Tri Cahyo Sepdianto Triantoro Safaria Umi Kulsum Qomariah Untung Widodo Wahyudi Wahyudi Wahyuni Inggit Pratiwi Wakhidian Solehatur Rohmah Widiani, Esti Wimpy Wimpy Winda Yunita Miftahul Jannah Wulida Litaqia Yofita Sandra, S.Pd., M.Pd., Zico Farlin, Dr. Budiwirman, M.Pd., Yuli Priyana YUYUN SRIKANDI Yuzarion, Yuzarion Zainuri Sabta Nugraha Zaitul Ummi