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HUSNUL KHOTIMAH
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Journal : Indian Journal of Forensic Medicine

 1 
Cardiac Fibrosis Attenuation by Chlorogenic Acid and Epigallocatechin-Gallate Mediated by Suppression of Galectin-3 Gene Expression and Collagen Deposition in Rat Metabolic Syndrome Model Indah Nur Chomsy; M. Saifur Rohman; Mifetika Lukitasari; Dwi Adi Nugroho; Husnul Khotimah
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14759

Abstract

Objective: Metabolic syndrome (MetS) is a set cluster of risk factors for metabolic abnormalities thatcan develop cardiovascular disease (CVD), one of that is remodeling or cardiac fibrosis. Cardiac fibrosisidentified from the high levels of the profibrotic molecule; one of them is galectin-3. Aim: This studyintended to determine the effect of combination therapy of green coffee (CGA) and green tea (EGCG) oncardiac fibrosis by raise of the galectin-3 gene expression and collagen deposition in rat cardiac tissue inthe rat metabolic syndrome model. Methods: Twenty-four male MetS rats (Sprague-Dawley) divided intotwo control groups and three groups therapy (n=5) administration of the CGA 200mg/kgbw (body weightin kilograms) and EGCG 300mg/kgbw orally. After eight weeks of treatment, rats euthanized, then mRNAexpression of galectin-3 was measured. Furthermore, collagen deposition of cardiac tissue carried out inhistology slides. Results: Research reveals that the expression of galectin-3 decreased in the metabolicsyndrome model group, which given combination therapy compared with metabolic syndrome model micethat did not receive any therapy (P=0.000). Collagen deposition in cardiac tissue also found less than inthe therapy group compared with the group not treated with both compounds (P=0.000). The correlationbetween the two parameters shows a positive association with low strength. Conclusion: This study showsthat the combination therapy of CGA and EGCG is an engaging therapeutic candidate. It expected to reducethe progression of cardiac fibrosis in metabolic syndrome
Co-Authors A. Otong Busthomi Abdul Hamid Wahid Ahmad Kholid Fauzi Amrullah Anak Agung Gede Sugianthara Anas Muhktar Andita Wahyuningtyas Anggaunita Kiranantika Anna Muawanah Aswati Aswati Ayuni Arfina Bagus Supriyadi Bakti Tamba Bambang Firmansyah Bambang Yulianto Dedi Ansori Desi Apriani Dhani Yuniati Duwi Lismawati Dwi Adi Nugroho Eka Yuli Astuti Elisa Nurul Laili Erizka Rivani Ester G Pansserga Evin Andriani Fatmawati Ferawati Ferawati Fitnaningsih Endang Cahyawati Fitriani Fitriani Gatut Rubiono Habibur Rahman Hadiyanto Harianto Budi Rahardjo Hary Soedarto Harjono Hasanuddin " HESTI ATASASIH I Ketut Karya Wisana Iin Sumarto Iis Iis Iis Trisnawati Ima Mulyawati Imas Sukaesih Sitanggang Indah Nur Chomsy Indhra Musthofa Irma Yeny Irman Hermadi Juju Jumena Kadar Kuswandi Khoirus Sachiyah Kholisotin, Kholisotin Kirnantoro Kirnantoro Lubna Maimunah M. Saifur Rohman Mifetika Lukitasari Mirhansyah Ardana Moch Sasmito Djati MUHAMMAD AGIL Mukhlis R Nadiyah Khairiyah Aziz Nanda Wahyu Anandita Novida Ariani Nur Amin Nur Samsu Nurul Badriyah Haqiqiyah Nyoman Sridana RACHMAT HIDAYAT Rahayu Sri Waskitoningtyas Rahman, Handono Fatkhur Ratna Yulis Tyaningsih Refi Lindawati Rejeki Siti Ferniah Ririn Maghfirah Risna Agustina Rizky Hafifatul Umam Roziana Roziana Santi Sundary Lintang Shanti Meris Dwi Astuti SITI AISAH Siti Durrotul Mukarromah Siti Nur Jannah Sri Astutik Andayani SRI UTAMI SUBAGIO Suci Yuniarti Sulfiati Ira Wijayanti Susy Katarina Sianturi Sutrisnak Sutrisnak Teguh Wahyono Tingga Sari Novi Prakaswati Tri Hariyati Nur Indah Sari Tuty L Yusuf Widhi Kurniawan Yani Nurhadryani YESSI ALZA Yuliono Trika Nur Hasan Zahrotul Wathoniyah,