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All Journal Hemera Zoa Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Farmasains : Jurnal Farmasi dan Ilmu Kesehatan COPING (Community of Publishing in Nursing) Jurnal Akademika Biologi Jurnal Ilmu Komputer dan Agri-Informatika Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Jurnal Online Mahasiswa (JOM) Bidang Ilmu Hukum Indonesian Journal of Pharmaceutical Science and Technology JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Journal of Agromedicine and Medical Sciences I-ECONOMICS: A Research Journal on Islamic Economics AlphaMath: Journal of Mathematics Education JURNAL PENDIDIKAN TEMATIK DIKDAS Al-Mustashfa JNKI (Jurnal Ners dan Kebidanan Indonesia) (Indonesian Journal of Nursing and Midwifery) Argipa (Arsip gizi dan Pangan) BASIS (BAHASA DAN SASTRA INGGRIS) INSPIRAMATIKA Jurnal Penelitian Sosial dan Ekonomi Kehutanan Al-Madrasah: Jurnal Ilmiah Pendidikan Madrasah Ibtidaiyah Jurnal Ilmiah Keperawatan (Scientific Journal of Nursing) PROSIDING SEMINAR NASIONAL PROGRAM PASCASARJANA PARAMUROBI Faletehan Health Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research de Fermat : Jurnal Pendidikan Matematika Abdimas Universal Keberlanjutan : Jurnal Manajemen dan Jurnal Akuntansi Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Jurnal Metaedukasi : Jurnal Ilmiah Pendidikan Journal of Classroom Action Research Tahdzib Al-Akhlaq: Jurnal Pendidikan Islam Indonesian Journal of Sociology, Education and Development (IJSED) Indian Journal of Forensic Medicine & Toxicology Edulead : Journal of Education Management Bioscientia Medicina : Journal of Biomedicine and Translational Research JCA (Jurnal Cendekia Akuntansi) Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Penyuluhan Agama Obstretika Scientia Pontianak Nutrition Journal (PNJ) Journal of Educational Engineering and Environment Jurnal Penelitian Sains dan Kesehatan Avicenna Jurnal Ilmiah Kesehatan Keperawatan
HUSNUL KHOTIMAH
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Journal : Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga.

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EFFECTS OF COWPEA (VIGNA UNGUICULATA) EXTRACT IN VEGF EXPRESSION OF CORNEAL INFLAMMATION RAT MODEL (RATTUS NOVERGICUS STRAIN WISTAR) Yuliono Trika Nur Hasan; Nanda Wahyu Anandita; Husnul Khotimah
Saintika Medika Vol. 10 No. 1 (2014): Juni 2014
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.v10i1.4148

Abstract

Purpose : to evaluate the effects of Methanolic extract of Cowpea (Vigna unguiculata) administration on vascular endothelial growthfactor (VEGF) expression in rats with corneal-alkali induced inflammation.Methods : This was an interventional experimental study. Sixty three rats were randomly selected, 3 rats as control, 60 rats were treatedwith 1 M NaOH (as inflammation model) and administered with 25 ìM,50 ìM and 100 ìM of genistein in Cowpea (Vignaungucuilata) extract four times daily. Alkali burn by 1 M NaOH infiltration using filter paper applicated on the center cornea of righteye for 60 seconds. Aquabidest as positive control and Cowpea (Vigna ungucuilata) extract treatment perfused immediately after alkali burn.VEGF observed at 6, 24, 48, 96 and 168 hours by immunohistochemical method.Results : Each dose of Cowpea (Vigna unguiculata) extract administration significantly decreased the VEGF expression ( p = 0,00). Differences of VEGF expression based on administration time were not significant (p=0,033). Interaction between time of administrationand dose of administration had influenced the VEGF expression (R Square(r2) =24,7 %). The Linear regression between VEGF expression and dose resulted in estimated effective dose (ED) with Y = 16.486–0.079 X( Y = V E G F e x p r e s s i o n , X =d o s e o f a d m i n i s t r a t i o n ) . Considering VEGF expression in normal cornea was 12, wefound the effective dose of methanolic Vigna unguiculata extract was 61.94 ìM.Conclusion :Methanolic extract of Cowpea(Vigna unguiculata) decreased the VEGF expression on alkali burn corneal inflammationin rats but no differences in VEGF expression based on time administration. Dose of 50 ìM genistein in Methanolic extract ofCowpea (Vigna unguiculata) was close to effective dose 61.94 ìM.Keywords : VEGF expression, alkali burn, Cowpea (Vigna unguiculata) extract, cornea.
Co-Authors A. Otong Busthomi Abdul Hamid Wahid Ahmad Kholid Fauzi Amrullah Anak Agung Gede Sugianthara Anas Muhktar Andita Wahyuningtyas Anggaunita Kiranantika Anna Muawanah Aswati Aswati Ayuni Arfina Bagus Supriyadi Bakti Tamba Bambang Firmansyah Bambang Yulianto Dedi Ansori Desi Apriani Dhani Yuniati Duwi Lismawati Dwi Adi Nugroho Eka Yuli Astuti Elisa Nurul Laili Erizka Rivani Ester G Pansserga Evin Andriani Fatmawati Ferawati Ferawati Fitnaningsih Endang Cahyawati Fitriani Fitriani Gatut Rubiono Habibur Rahman Hadiyanto Harianto Budi Rahardjo Hary Soedarto Harjono Hasanuddin " HESTI ATASASIH I Ketut Karya Wisana Iin Sumarto Iis Iis Iis Trisnawati Ima Mulyawati Imas Sukaesih Sitanggang Indah Nur Chomsy Indhra Musthofa Irma Yeny Irman Hermadi Juju Jumena Kadar Kuswandi Khoirus Sachiyah Kholisotin, Kholisotin Kirnantoro Kirnantoro Lubna Maimunah M. Saifur Rohman Mifetika Lukitasari Mirhansyah Ardana Moch Sasmito Djati Mohammad Irwansyah MUHAMMAD AGIL Mukhlis R Nadiyah Khairiyah Aziz Nanda Wahyu Anandita Novida Ariani Nur Amin Nur Samsu Nurul Badriyah Haqiqiyah Nyoman Sridana RACHMAT HIDAYAT Rahayu Sri Waskitoningtyas Rahman, Handono Fatkhur Ratna Yulis Tyaningsih Refi Lindawati Rejeki Siti Ferniah Ririn Maghfirah Risna Agustina Rizky Hafifatul Umam Roziana Roziana Santi Sundary Lintang Shanti Meris Dwi Astuti SITI AISAH Siti Durrotul Mukarromah Siti Nur Jannah Sri Astutik Andayani SRI UTAMI SUBAGIO Suci Yuniarti Sulfiati Ira Wijayanti Susy Katarina Sianturi Sutrisnak Sutrisnak Teguh Wahyono Tingga Sari Novi Prakaswati Tri Hariyati Nur Indah Sari Tuty L Yusuf Widhi Kurniawan Yani Nurhadryani YESSI ALZA Yuliono Trika Nur Hasan Zahrotul Wathoniyah,