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All Journal Dentika Dental Journal Jurnal Sains dan Teknologi Farmasi Science and Technology Indonesia Jurnal Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Hilirisasi IPTEKS (JHI) Jurnal Farmasi Higea Jurnal Prima Medika Sains (JPMS) JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Andalas Dental Journal Formosa Journal of Sustainable Research (FJSR) Jurnal Farmasi Indonesia
Yufri Aldi
Fakultas Farmasi Universitas Andalas Padang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Science and Technology Indonesia

 1 
Preparation and Characterization of a Eutectic Mixture of Fenofibric Acid and Nicotinic Acid and Evaluatuion of In Vivo Antihyperlipidemic Activity Deni Anggraini; Hulwa Salsabila; Salman Umar; Yufri Aldi; Erizal Zaini
Science and Technology Indonesia Vol. 7 No. 4 (2022): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1086.036 KB) | DOI: 10.26554/sti.2022.7.4.514-521

Abstract

Fenofibric Acid (FA) is classified under Biopharmaceutical Classification System (BCS) class II due to its poorly soluble in water and high permeability. The present study aimed to prepare the eutectic mixture of FA with nicotinic acid (NA) and characterize its solid state properties and in vitro dissolution rate, along with its in vivo antihyperlipidemic activity. Solvent drop grinding was the method chosen to prepare the eutectic mixture of FA and NA. Solid-state properties were evaluated using thermal analysis Differential Scanning Calorimetry (DSC), crystallographic analysis Powder X-Ray Diffraction (PXRD), FT-IR spectroscopic analysis, and Scanning Electron Microscopy (SEM). To examine in vivo antihyperlipidemic activity, 16 male Swiss Webster rats were injected with 1% hyperlipidemia-inducing solution, followed by the oral administration of 9.45 mg/kg FA and NA (equivalent to 9.45 mg/kg FA), after which the decrease in cholesterol levels was measured. Two-way ANOVA was used to evaluate the data, followed by Duncan’s multiple range test (95% confidence interval). The results proved that FA formed the eutectic mixture with NA at a molar ratio of 6:4. The eutectic mixture of FA-NA had a better solubility and in vitro dissolution rate compared to intact FA, which also led to notably improved antihyperlipidemic activity.
Co-Authors . Dachriyanus . Yanwirasti Aditya Alqamal Alianta Adrul Fauzan Afriwardi Afriwardi Agung Aji Wahyudi Akmal Djamaan Aminah Panggabean Amri Bakhtiar Andani Eka Putra Arfiandi Arfiandi Ben, Elfi Sahlan Deni Anggraini Densi Selpia Sopianti Densi Selpia Sopianti Dewi Gulyla Hari Dian Handayani Dian Handayani Diana Laila Ramatillah Diana Laila Ramatillah Dwisari Dillasamola Elda Mayanti Elidahanum Husni Elisma Elisma Ellyza Nasrul Elsa Badriyah Enda Markus Aginta Sembiring Erizal Erizal Erizal Zaini Fatma Sri Wahyuni Fifi Harmely Fildzah Nurul Fajrin, Fildzah Nurul Fransisca Gloria Fransisca Gloria Hansen Nasif Havizur Rahman Herwinda Julia Putri Hulwa Salsabila Ida Paulina Lita Tri Astari M Asmadi Mahyudin Mahyudin Marlina . Michael Michael Michael Michael Muhammad Islamoyo Muhammad Syafrudin Nikita Surya Dharma Nila Kasuma Nindya Prastiwi Nisya Ogiana Nurliyasman Prastiwi, Nindya Purnawan Pontana Putra Rahmi Nofita Rozi Efendi Rury Trisa Utami Rustini Rustini Salman - Salman Salman Salman Umar Salman Umar Sirda Yenni Sri Oktavia Stefanus Lukas Stefanus Lukas Suci Sutma Suhatri Suhatri Surya Nelis Susi Susi Widya Kardela Widya Nengsih Yahdian Rasyadi Yanelita Vipri Yanwirasti Yanwirasti Yaser Arafat Yelly Oktavia Sari Yohannes Alen Zet Rizal