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Journal : Andalas Dental Journal

UJI ANTI INFLAMASI SECARA TOPIKAL EKSTRAK ETANOL UMBI SARANG SEMUT (Myrmecodia tuberosa Jack) PADA MENCIT PUTIH JANTAN Muhammad Islamoyo; Yufri Aldi; Surya Nelis
Andalas Dental Journal Vol 5 No 2 (2017): Andalas Dental Journal
Publisher : Faculty of Dentistry Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (486.866 KB) | DOI: 10.25077/andalas dent. j..v5i2.77

Abstract

Inflammation is a tissue response towards damaging physical or chemical stimulations. One local sign of inflammation is edema (tumor). Usage of natural herbal medicine has become an alternative way to prevent inflammation. The extract of umbi sarang semut (Myrmecodia tuberosa Jack) has anti-inflammation, anti-bacterial and antioxidant properties. This study is to determine the anti-inflammation effect of the topical application of Myrmecodia tuberosa Jack ethanol extract. This study used 28 white male rats previously induced with carragenin 2% b/v 0,5ml and divided into 4 treatment groups. Groups 1,2 dan 3 were given the ethanol extract with a concentration of 0,5 %; 1%; 2% respectively after induction and on 24, 48 and 72 hours after the first application. Group 4 was the untreated control group. Each treatment group were extracted for their inflammation exudate fluid from their backs using a 1 ml syringe. Edema fluid volume was measured. The results showed a decrease of edema fluid volume on all treatment groups. Statistical data analysis showed a significant difference between group 2 and the negative control; also between group 3 and the negative control. In conclusion, the topical ethanol extract of Myrmecodia tuberosa Jack can reduce inflammation reactions. Keywords: Myrmecodia tuberosa Jack, anti-inflammation, topical, edema fluid volume
DAYA HAMBAT JUS APEL MANALAGI (MALUS SYLVESTRIS) TERHADAP PERTUMBUHAN BAKTERI PORPHYROMONAS GINGIVALIS SECARA IN-VITRO Enda Markus Aginta Sembiring; Yufri Aldi; Susi Susi
Andalas Dental Journal Vol 6 No 2 (2018): Andalas Dental Journal
Publisher : Faculty of Dentistry Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (252.13 KB) | DOI: 10.25077/adj.v6i2.122

Abstract

Background: Periodontitis are one of teeth and mouth disease with prevalence is 50% of adult. Periodontitis is an inflammatory condition that cause damage to connective tissue and alveolar bone. Porphyromonas ginggivalis is one of anaerob gram-negative bacteria that cause periodontitis, these bacteria can withstand host’s defenses mechanism by utilizing a virulence factor panel that cause derived innate immune and inflamatory responses. Apple Manalagi or known as apple Malang is one of the herbal plants in Indonesia. Some studies represented inhibitory effect for bacteria from its substance. Objective: The objective of this study were to determine inhibitory effect of apple manalagi (Malus sylvestris) for Porphyromonas ginggivalis. Method: Experimental laboratory. In this study Apple Manalagi will be Juiced, Juice Apple Manalagi will divide by 4 concentrate 25%, 50%, 75% and 100%. This study use diluusion method, juice apple Manalagi will aplicated to 5 samples agar MHA for 5 times. The inhibitory effect will calculated with sliding calipers, and then data will process with one way anova. Result: The result didn’t show any inhibision zone in MHA to Porphyromonas ginggivalis so data analysis cann’t be done. Conclusion: Apple Manalagi doesn’t have inhibitory effect for Porphyromonas ginggivalis.