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Journal : Embrio : Jurnal Kebidanan

Pengaruh Extra Virgin Olive Oil (EVOO) terhadap Berat Plasenta dan Berat Badan Janin pada Tikus Wistar Model Preeklampsia Dwi Norma Retnaningrum; Wenny Rahmawati; Alfima Rahasti
EMBRIO Vol 13 No 2 (2021): EMBRIO (NOVEMBER 2021)
Publisher : Program Studi S1 Kebidanan - Fakultas Sains dan Kesehatan Universitas PGRI Adi Buana Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/embrio.v13i2.3699

Abstract

Preeclampsia was defined as new onset hypertension and proteinuria after 20 weeks of gestation in which the mother had no previous history of hypertension. Preeclampsia is a disorder that often occurs in pregnancy with an incidence rate of 2-8% among pregnancies in the world. Preeclampsia ranks 2nd as a cause of maternal death (MMR). In East Java, preeclampsia was ranked 1st as the cause of AKI in 2016. Preeclampsia as one of the main causes of maternal death can be detected and treated properly before the emergence of life-threatening complications such as eclampsia. In severe cases, preeclampsia increases the risk of comorbidities such as Hemolysis, Elevated Liver Enzyme Levels, and Low Platelet Levels (HELLP) syndrome, edema, Disseminated Vascular Coagulation (DIC), and eclampsia/cerebral edema, whereas in fetus preeclampsia is associated with intrauterine growth restriction. (IUGR), prematurity and fetal death. Extra virgin olive oil (EVOO) is obtained from olives in a mechanical way that does not change the composition of the oil. Research on EVOO has been widely studied in a broad spectrum which explores its content as antioxidants and also anti-inflammatory polyphenols and tocopherols that can be used as anti-oxidants and also anti-inflammatory. The purpose of this study was to prove the role of EVOO on placental and fetal weight in preeclampsia model Wistar rats. The design of this study was experimental (quasi experimental) with a posttest only control group design approach. This study consisted of 5 groups, negative group, positive group (preeclampsia model rats), treatment groups 1, 2 and 3, namely preeclampsia rats that were given EVOO in 3 different doses (each 0.5ml/day, 1ml/day, 2 ml/day). After being sacrificed, the placenta and fetus are weighed to determine their weight. The results showed that the administration of EVOO was effective in increasing the weight of the placenta and fetus in preeclampsia model rats with a P value of 0.000 (P<0.05).
Co-Authors , Handoko . Sugiyanta, . A Ali A. S. Suharyono Abdul Harris Burhan Abdullah Abdullah Ade Sumiahadi AHMAD JUNAEDI Ahmad Junaidi Aidi Noor Aji Hermawan Aldi M Alfima Rahasti Anas M. Fauzi Andhini, Martika Ani Kurniawati Anita Ristianingrum Ansyarif Khalid Artha Regina Tambunan Asdi Asdi Asep Nursangaji Asih Sukowati Astuti DA Astuti DA Awang Maharijaya Axel Anderson Ayu Vandira Candra Kusuma Bambang Pramudya Bambang S. Purwoko Bustami Syam Chairannisa, Dyana D.A. Astuti dan Kukuh Murtilaksono DARUSMAN, L.K. Darwis AN Darwis AN Desta Wirnas dewi novita Diah karyawati Dina Harsono Dwi Guntoro Dwiwanti Sulistyowati E. Namaken Sembiring Edi Santosa Edy Yusmin Eka Intan Kumala Putri Eka Wardiana EVA OKTAVIDIATI, EVA Faradesi Ardialisa Faras Gaitsa Bilkis Fibra Nurainy Gerson Hans Maure GHULAMAHDI, M. Gretty Febriola Siahaan h sanusi H. Soedarmadi HAJRIAL ASWIDINNOOR Hartami Dewi Hemawati Hemawati Hendrik Hendrik Herman Wafom Tubur Hesty Juniar Rukmin Hiroshi Ehara Hongarta, Reynaldo Ida H. Somantri Indriani Santoso Iqbal . Irwan Abdullah Iskandar Lubis ISMAIL SALEH Iswari S. Dewi Jalali Iqram Kanny, Putri Irene Karti PDMH Karti PDMH Khairil Anwar Krishna Surya Buana KWANG HO KIM Laila Nur Atika Lalu Muhamad Zarwazi Luki Abdullah M Zardan Araby M. Ghulamahdi Machfud Machfud Maisura Maisura Maria Erna Marmawi R . Maya Melati Mochammad Afifuddin Moeljarno Djojomartono Muftil Badri Muhamad Kurniadi Muhamad Syukur Muhammad Syaifuk Ar Rosyid Munawir, Fathurrahman Aziz MUNIF GHULAMAHDI P.M.D.H Karti, P.M.D.H Pangerang, Utama K. Perwita, Atikah Dyah Purwono Purwono Putri Sakura Raisa Baharuddin RANI FARIDA Ratih Marina Kurniaty Rinaldo, Ruswandi Ritonga, Arya Widura Sahrullah Sahrullah Sangrani Annisa Dewi Selvie D. Anis Selvie Diana Anis Sigit Prabawa Sobir Sobir Soedarmadi Hardjosoewignyo Soekisman Tjitrosemito Sofyan Zaman Sri Mulatsih Sudirman Yahya Sudradjat Sudradjat Sugiyanta Suryana Sutikno Sutikno Suwarto Tanto Pratondo Utomo Tineke Mandang Ulinnuha, Zulfa urai salam Vivid Violin Wenny Rahmawati WIJAYANTO, N. Yasidi, Farid Yudi Febrianto Yudi Febrianto Yuline . Yundari, Yundari Yuniarti , Zulfa Ulinnuha