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All Journal Majalah Kedokteran Bandung Jurnal Kesehatan Andalas Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Journal of Midwifery Jurnal Respirologi Indonesia Majalah Kedokteran Andalas International Islamic Medical Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia
Aisyah Elliyanti
Nuclear Medicine Division, Faculty Of Medicine, Universitas Andalas
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : International Islamic Medical Journal

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Treatment Problems In Triple Negative Breast Cancer Thira Fasril; Noza Hilbertina; Aisyah Elliyanti
Jurnal Medis Islam Internasional Vol 4 No 2 (2023): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v4i2.3951

Abstract

Background: Breast cancer ranks second on the list of common diseases worldwide. It causes many deaths in the United States and Europe, second only to lung cancer. Triple-negative breast cancer (TNBC) does not express Estrogen Receptor (ER), Progesterone Receptor (PR), and Human Epithelial Receptor (HER2). It represents 24% of new cases of all breast cancer, and its incidence increases yearly. TNBC is a hormone-resistant breast cancer, so no current standard therapy exists. This article aims to explore regimen-resistant and troubleshooting treatment responses in TNBC cases. The method of writing this article is a literature review of studies using the keywords triple-negative breast cancer treatment and regimen, which are limited to only the most recent articles, 2012-2022, using search engines from PubMed, Science Direct, and Google Scholar. Results: There is no definitive therapy for the triple-negative breast cancer subtype, in which the TNBC type has no target receptor. Chemotherapy is the SOC of TNBC for early stage treatment. For late-stage and relapsed TNBC, however, chemotherapy is no longer the first choice. Currently there is no standard chemotherapy regimen that can be given to patients who experience relapse after chemotherapy because they will have a short response and lead to metastases. Some studies have shown that chemotherapy gives a better response, but the prognosis of TNBC remains poor. TNBC has different responses to therapy. TNBC showed a good response to combination chemotherapy along with pembrolizumab, capecitabine, olaparib, and radiotherapy, compared to chemotherapy by itself. Surgical therapy, such as Breast-Conserving Surgery (BCS), does not improve better prognosis in TNBC patients. Conclusions: Combining pembrolizumab, olaparib, capecitabine, and radiotherapy with chemotherapy increased survival rates compared to chemotherapy only.
Co-Authors Afriwardi Afriwardi Andani Eka Putra Arina Widya Murni Arnelis Arnelis Arni Amir Ashal, Taufik Aswiyanti Asri Daan Khambri Dewi Anggraini Dian Pertiwi Dian Pertiwi Dodi Safari Elizabeth Bahar Elmatris Sy Eryati Darwin Eti Yerizel Eti Yerizel Faiz Chalidzar Fika Anggraini Fitri Wahyu Febriwani Hendriati, Hendriati Herlambang Herlambang Husnil Wardiyah Ika Kurnia Febrianti Ilmiati Ilmiati Indra Yovi Iskandar Iskandar Johan S. Masjhur, Johan S. Julizar Julizar Julizar Julizar Katrin Monika Lili Irawati Meidrin Joni Miftah Irrahmah Miftah Irramah Mohamad Reza Noormartany . Nora Harminarti Noza Hilbertina Nur Afrainin Syah Nurhajjah, Sitti Rahmad Syawqi Rahmat Syawqi RAVEINAL RAVEINAL Rina Gustia S Setiyowati Sabar Hutabarat Siti Nurhajjah Sorayya A'dilah Putri Suminta RS, Teresia Syaiful Azmi Tenny Putri Wikayani, Tenny Putri Thira Fasril Tri Hanggono Achmad Vanesya Zahrani Shapira VY Susilo Yose Ramda Ilhami Yose Ramda Ilhsmi Yulia Iriani, Yulia Yulia Kurniawati Yulia Kurniawati Yulistini, Yulistini Zelly Dia Rofinda Zelly Dia Rofinda Zulfa Nur Hanifah