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All Journal Majalah Kedokteran Bandung Jurnal Kesehatan Andalas Jurnal Kesehatan Manarang Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Journal of Midwifery Jurnal Respirologi Indonesia Majalah Kedokteran Andalas International Islamic Medical Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia (JIKSI)

Aisyah Elliyanti

1) Nuclear Medicine Division Of Radiology Department, Faculty Of Medicine, Universitas Andalas, Padang, Indonesia 2) Dr. M. Djamil Hospital, Padang, Indonesia

Author-ID : 5485068

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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TRACER STUDY FK UNAND 2008 : PERSEPSI ALUMNI TERHADAP PELAKSANAAN PENDIDIKAN KEDOKTERAN DI FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS Yulistini Yulistini; Aisyah Elliyanti; Nora Harminarti; Taufik Ashal; Ilmiati Ilmiati
Majalah Kedokteran Andalas Vol 34, No 2 (2010): Published in August 2010
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakTracer Study adalah penelitian yang menghimpun informasi tentang sebaran para alumni dan berbagai masukan yang dapat membantu pengembangan kurikulum dan proses pembelajaran di Fakultas Kedokteran Universitas Andalas (FK Unand).Penelitian tracer study di FK Unand 2008 menggunakan pendekatan kuantitatif dengan metode deskriptif analitik. Respondennya adalah alumni FK Unand yang dipilih secara purposive random sampling, yaitu berdasarkan keikutsertaan kegia-tan ilmiah dan kegiatan lainnya di FK Unand tahun 2008.Hasil penelitian menunjukkan persentase responden yang puas dan tidak puas terhadap pelayanan akademik sebanyak 55,5% dan 45,5% dari 124 responden. 61,9% responden merasa puas terhadap pendidikan preklinik dan 50,4% merasa puas terhadap pendidikan klinik. Untuk penilaian kompetensi berdasarkan persepsi responden menunjukkan 66,7% merasa kompeten saat menyelesaikan pendidikan. Uji bivariant menunjukkan hubungan bermakna antara kepuasan terhadap pendidikan preklinik dan klinik, tahun masuk dan jenis kelamin terhadap kompetensi (p<0.05).Kesimpulan adalah sebagian besar responden merasa puas terhadap pelayanan akademik dan pendidikan preklinik. Persentase ketidakpuasan terhadap pen-didikan klinik hanya sedikit lebih tinggi dari pada yang puas. Terdapat hubungan yang bermakna antara kepuasan terhadap pendidikan preklinik, klinik, tahun masuk, dan gender terhadap persepsi responden terhadap kompetensi mereka.Kata kunci :tracer study, alumni, tahun masuk, pre klinik, klinik, kompetensiAbstractTracer Study is a research that gather information about the distribution of the alumni and the various inputs that may help the development of curriculum and learning process in the Faculty of medicine Andalas University (FK Unand) Tracer studies FK Unand 2008 using a quantitative approach with a descriptiveARTIKEL PENELITIAN168analytical method. Respondents are FK Unand’s graduates that selected by purposively random sampling, who followed FK Unand’s scientific activities and other during 2008.The results show the percentage of respondents who are satisfied and not satisfied with the academic services as much as 55.5% and 45.5% of 124 respondents. 61.9% of respondents were satisfied with preclinical education and 50.4% were satisfied with educational clinics. For the respondents' perceptions of their competence indicated the majority (66.7%) felt competent at completing education. Bivariant test showed a significant relationship between satisfaction in preclinical and clinical stage, years in and to their competency (p<0.05).The conclusion are most respondents were satisfied with the academic services and preclinical stage. The percentage of dissatisfaction with clinic stage just slightly higher than who satisfied. There is a significant association between satisfaction with preclinical and clinical stage, year in, and gender to respondent's perception of their competence.Key word : tracer study, alumni, year-in, pre-clinical, clinical, competence

PERAN C-FOS SEBAGAI AGEN PROLIFERASI DAN PRO-APOPTOSIS SEBAGAI STRATEGI PENGEMBANGAN PENGOBATAN KANKER Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 39, No 2 (2016): Published in August 2016
Publisher : Faculty of Medicine, Universitas Andalas

Analisis profil molekuler telah memberikan pengertian lebih dalam berkenaan dengan kompleksitas penyakit kanker di tingkat molekuler serta membuka potensi pengunaannya untuk mempelajari jalur onkogenik, hubungan jalur keganasan dengan sensitivitas terhadap terapi yang memberikan potensi yang besar sebagai petunjuk pengunaan terapi target. C-Fos merupakan proto-onkogen, berikatan dengan Jun membentuk komplek faktor transkripsi activating protein 1 (AP-1). Sebagai anggota dari AP-1, c-Fos memainkan peran merespon transduksi sinyal proliferasi dan diferensiasi sel yang menyebabkan pertumbuhan sel yang invasif. Sebaliknya laporan penelitian lainnya membuktikan bahwa c-Fos juga memiliki peran sebagai tumor supresor dengan keterlibatannya pada proses apoptosis. Mekanisme molekuler yang jelas tentang keterlibatan c-Fos baik sebagai tumor modulator proliferasi sel maupun supresor pertumbuhan tumor masih belum jelas. Penelitian lebih lanjut keterlibatan c-Fos di tingkat molekuler sangat penting untuk membuka jalan bagi target baru terapi kanker maupun sebagai marker prognostik penyakit kanker.

Progressive evolution of thyroid adenoma to thyroid carcinoma Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 42, No 3 (2019): Published in September 2019
Publisher : Faculty of Medicine, Universitas Andalas

Nodules (adenomas), enlarged thyroid (goiter) and inflammation of the thyroid (thyroiditis) are the most important risk factors for thyroid cancer. Adenomas have the largest increase in risk. Objectives: to discuss two cases of adenomas goiter that became aggressive during follow-ups. Cases: Two patients, with an average age of 64 years, referred to Nuclear Medicine dr. M. Djamil Hospital in Padang for bone scintigraphy examination. Both patients had thyroid surgery and histopathology results were adenomas. However, after the removal surgery, the patients did not have proper follow-ups. Both patients developed pelvic pain. Bone scintigraphy showed an increase of radiopharmaceutical uptake at pelvic bones and computerized tomography (CT Scan) result showed destruction at the pelvic bone areas. Conclusions: These cases highlight the necessity for adenoma thyroid patients with a risk factor for thyroid cancer to have a complete follow-up program and sufficient length period.

Uptake and effect of radioiodine exposure on SKBR-3 cell lines Miftah Irramah; Yulia Kurniawati; VY Susilo; S Setiyowati; Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 43, No 1 (2020): Published in January 2020
Publisher : Faculty of Medicine, Universitas Andalas

Radioiodine has been known as an adjuvant therapy for thyroid cancer. Beside for thyroid cell, radioiodine is reported to be taken up by breast cell. It may be proposed as an alternative for breast cancer therapy. Objective: The study aim was to analyze an uptake of radioiodine and cell proliferation rate of breast cancer cell after the exposure of radioiodine. Methods: This study used SKBR-3 cell line as representative of Human Epidermal Growth Factor Receptor (HER2+) subtype. The cells were planted in DMEM medium added 10% fetal bovine serum (FBS), panstrep 1% and amphotericin B. The cells were grown until 80% confluent and then stripped. Subsequently the cells were sub-cultured on plates 12 and 6 wells respectively for measured uptake of radioiodine and cell proliferation rate after the exposure. Radioiodine uptake was calculated by sum efflux of 125 Iodine (125I) and the amount of uptake after the addition of 95% ethanol. Cell proliferation rate was measured by calculated by using clonogenic assay after iodine-131 (131I) exposure. Results: The average of iodine uptake was 194±50 cpm/106 cell. The average cell proliferation after radioiodine exposure was 54%±5%; Conclusions: Radioiodine is taken by SKBR-3 cells and it reduced cell proliferation rate. This finding shows an opportunity for radioiodine as an alternative therapy for breast cancer. Another studies are needed to understand of cell death the mechanism.

CORRELATION OF RENOGRAM WITH CYSTATIN-C LEVELS AND CREATININE CLEARANCE IN MEASURING GLOMERULAR FILTRATION RATE Aisyah Elliyanti; Iskandar Iskandar; Syaiful Azmi
Majalah Kedokteran Andalas Vol 38, No 1 (2015): Published in May 2015
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakRenogram 99mTc-DTPA (diethylenetriamine pentacetic acid) memiliki beberapa kelebihan dalam mengukur laju filtrasi glomerulus (LFG). Cystatin-c digunakan sebagai petanda biologik baru untuk memperkirakan LFG. Tujuan penelitian ini adalah untuk menentukan korelasi nilai LFG antara renogram dengan cystatin-c dan kliren kreatinin pada pasien dengan penyakit ginjal kronis (PGK). Subjek penelitian adalah pasien PGK stadium dua berdasarkan hasil estimasi LFG dengan rumus Cockroft-Gault. Pasien yang memenuhi kriteria diperiksa renogram, kadar kreatinin serum, cystatin-c dan klirens kreatinin.Rerata LFG dari 30 orang subjek yang diperiksa dengan renogram, cystatin-c, creatinine clearance, Cockroft-Gault’s formula berturut turut adalah 64.96 ml/min/1.73m2 (SD 28.047), 53.37 ml/min/1.73m2 (SD 21.29), 58.09 ml/min/1.73m2 (SD 35.45), 46.00 ml/min/1.73m2 (SD 12.06). Korelasi antara renogram dengan cystatin-c dengan nilai r = 0.585 dan p = 0.0007, antara renogram dengan klirens kreatinin dengan nilai r = 0.388 dan p = 0.03) dan antara renogram dengan rumus Cockroft-Gault’s dengan nilai r = -0.029 dan p=0.87. Pada penelitian ini didapatkan hasil korelasi yang lebih baik antara renogram dengan cystatin-c dari pada antara renogram dengan klirens kreatinin dan antara renogram dengan rumus Cockroft-Gault’s. Lebih lanjut, cystain-c merupakan alternatif yang lebih baik untuk memperkirakan LFG jika metode pemeriksaan LFG yang mendekati teknik pemeriksaan yang ideal tidak tersedia.AbstractRenogram using 99mTc-DTPA (diethylenetriamine pentacetic acid) has advantages in the measurement of glomerular filtration rate (GFR). Serum cystatin-c was recently projected to be the new marker of estimated GFR. The aim of this study is to establish correlation between GFRs, derived from renogram with cystatin-c levels and creatinine clearances in chronic kidney disease patients.We put to study thirty consecutive stage two of chronic kidney disease patients assigned based on GFR estimation by Cockroft-Gault’s formula, taking into account the serum creatinine. Cystatin-c and creatinine clearance were performed to determine of GFR and renogram was included in this study. A total of thirty subjects, the mean of GFRs were taken from renogram, cystatin-c, creatinine clearance, Cockroft-Gault’s formula were 64.96 ml/min/1.73m2 (SD 28.047), 53.37 ml/min/1.73m2 (SD 21.29), 58.09 ml/min/1.73m2 (SD 35.45), 46.00 ml/min/1.73m2 (SD 12.06) respectively. A correlation between renogram with cystatin-c (r = 0.585 and p = 0.0007) and renogram with creatinine clearance (r = 0.388 and p = 0.03) and renogram with Cockroft-Gault’s formula (r = -0.029 and p=0.87). This study has shown that a better correlation between renogram with cystatin-c than with creatinine clearance or Cockroft-Gault’s formula. Furthermore, cystain-c would be better alternative method incase having problems to obtain a closest ideal methods for GFR.

Hubungan Nilai Treshold dengan KadarAngiotensin Converting Enzyme-2 Sabar Hutabarat; Eti Yerizel; Aisyah Elliyanti; Yulia Iriani
Majalah Kedokteran Andalas Vol 46, No 2 (2023): Online April 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i2.p424-428.2023

Introduction: The coronavirus disease-19 (COVID-19) pandemic has been a major problem in every country worldwide. Cases of COVID-19 in children are usually caused by exposure to infected family members or other adults infected with the disease. Clinical manifestations in children vary widely from symptomatic to asymptomatic. This study aims to determine the relationship between cycle threshold (Ct) value with Angiotensin Converting Enzyme-2 (ACE-2) Method: This study is an observational study with a cross-sectional design. The purpose is to analyze the relationship between Ct value with ACE-2, IL-6, IL-10 level in asymptomatic COVID-19 pediatric patients. Ct value measured using RT-PCR and ACE 2, Il-6 and IL-10 were measured using ELISA examinations. Result: Mean of ACE-2 is 132,66 ± 38,19 pg/mL (21,63 – 171,63 pg/m). Conclusion: The majority of Ct value in asymptomatic pediatric COVID-19 patients were high (85,7%). Statistically, there was no significant correlation between Ct value with ACE-2, IL-6 and IL-10 in COVID-19 asymptomatic children. Keyword: Angiotensin Converting Enzyme-2, Covid-19 Asymptomatic Children

Hubungan HBD-3 Pada Selaput Amnion Ketuban Pecah Dini dengan Persalinan Normal Meidrin Joni; Eryati Darwin; Herlambang Herlambang; Aisyah Elliyanti Elliyanti
Majalah Kedokteran Andalas Vol 46, No 5 (2023): Supplementary July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i5.p801-804.2023

Tujuan: untuk melihat perbedaan kadar protein HBD-3 antara kejadian KPD dengan persalinan normal. Metode: Penelitian ini merupakan penelitian observasional dengan desain case-control untuk menilai rasio HBD-3 pada selaput amnion pada KPD dan persalinan normal. Hasil: Hasil penelitian ini menunjukkan bahwa konsentrasi HBD-3 pada grup KPD (3,10 ng/mL) yang tidak berbeda signifikan (P=0,537) dibandingkan grup kelahiran normal (3,10 ng/mL). Kesimpulan: Tidak terdapat perbedaan kadar protein HBD-3 antara kejadian KPD dan persalinan normal.

Pengaruh pemberian Iodine-131 terhadap viabilitas cell line Triple Negative Breast Cancer (TNBC) Katrin Monika; Aisyah Elliyanti; Yulia Kurniawati
Majalah Kedokteran Andalas Vol 46, No 6 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p912-918.2023

AbstractObjective: To determine the effect of Iodine-131 administration on the viability of triple negative breast cancer cell lines and the IC50 value of Iodine-131. Methods: This study was a true experimental study using the MTT assay method to measure cell line viability after being given Iodine-131 at a dose of 7.8; 15.6; 31.3; 62.5; 125; 250; and 500 µCi for 24 hours. The research sample was the MDA-MB231 cell line which represents the Triple Negative Breast Cancer (TNBC) subtype of breast cancer. The IC50 value of Iodine-131 cell line MDA-MB231 was calculated using the GraphPad Prism-9 software. The results were analyzed using the Kruskal-Wallis and Post-Hoc Kruskal-Wallis tests, if p <0.05 was considered to significantly affect cell viability. Results: Iodine-131 affected cell viability in the MDA-MB231 cell line with a p<0.05. The IC50 value of Iodine-131 on the MDA-MB231 cell line was 255.7 µCi. Conclusion: Administration of Iodine-131 at a dose of 500 µCi for 24 hours significantly reduced the viability of the MDA-MB231 cell line. Iodine-131 dose of 255.7 µCi can inhibit 50% viability of the MDA-MB231 cell line.Keywords: Iodine-131; cell viability; cell line MDA-MB231; TNBC; IC50

The Enhancement of COVID-19 Severity on Coagulation Markers: a Cross-sectional Study in West Sumatra, Indonesia Ika Kurnia Febrianti; Andani Eka Putra; Raveinal Raveinal; Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1712-1723.2024

Objective: This study aimed to determine the description of the coagulation marker and how it implicates COVID-19 patients based on clinical outcomes in the form of enhancement severity and death. Method: The subjects were collected from patients with positive COVID-19 RT-PCR with medical records including demographic data, and laboratory results such as hemoglobin, hematocrit, leukocytes, platelets, coagulation markers (D-dimer, PT, and APTT), and patients outcomes post-treatment. Statistical analysis is performed by using chi-square and Mann-Whitney tests were considered statistically difference level of significant between variables. Result: The COVID-19 patients is classified into mild group with 27 subjects (44.2%) and moderate-severe group 34 subjects (55.8%). Leukocytes, D-dimer, and PT levels significantly differed between mild and moderate-severe groups. All coagulation markers had a symptomatic effect on Covid-19 patients, increased D-dimer and prolonged prothrombin time in adult COVID-19 patients tend to be followed by the enhancement of severe symptoms and death

Co-Authors Afriwardi Afriwardi Andani Eka Putra Arina Widya Murni Arnelis Arnelis Arni Amir Ashal, Taufik Aswiyanti Asri Daan Khambri Dewi Anggraini Dian Pertiwi Dian Pertiwi Dodi Safari Elizabeth Bahar Elmatris Sy Eryati Darwin Eti Yerizel Eti Yerizel Faiz Chalidzar Fika Anggraini Fitri Wahyu Febriwani Hendriati, Hendriati Herlambang Herlambang Husnil Wardiyah Ika Kurnia Febrianti Ilmiati Ilmiati Indra Yovi Iskandar Iskandar Johan S. Masjhur, Johan S. Julizar Julizar Julizar Julizar Katrin Monika Lili Irawati Meidrin Joni Miftah Irrahmah Miftah Irramah Mohamad Reza Noormartany . Nora Harminarti Noza Hilbertina Nur Afrainin Syah Nurhajjah, Sitti Rahmad Syawqi Rahmat Syawqi Raihan Syah Ibrahim RAVEINAL RAVEINAL Rina Gustia S Setiyowati Sabar Hutabarat Siti Nurhajjah Sorayya A'dilah Putri Suminta RS, Teresia Syaiful Azmi Tenny Putri Wikayani, Tenny Putri Thira Fasril Tri Hanggono Achmad Vanesya Zahrani Shapira VY Susilo Yose Ramda Ilhami Yose Ramda Ilhsmi Yulia Iriani, Yulia Yulia Kurniawati Yulia Kurniawati Yulistini, Yulistini Zelly Dia Rofinda Zelly Dia Rofinda Zulfa Nur Hanifah

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