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All Journal Majalah Kedokteran Bandung Jurnal Kesehatan Andalas Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Journal of Midwifery Jurnal Respirologi Indonesia Majalah Kedokteran Andalas International Islamic Medical Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia

Aisyah Elliyanti

Nuclear Medicine Division, Faculty Of Medicine, Universitas Andalas

Author-ID : 5485068

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Progressive evolution of thyroid adenoma to thyroid carcinoma Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 42, No 3 (2019): Published in September 2019
Publisher : Faculty of Medicine, Universitas Andalas

Nodules (adenomas), enlarged thyroid (goiter) and inflammation of the thyroid (thyroiditis) are the most important risk factors for thyroid cancer. Adenomas have the largest increase in risk. Objectives: to discuss two cases of adenomas goiter that became aggressive during follow-ups. Cases: Two patients, with an average age of 64 years, referred to Nuclear Medicine dr. M. Djamil Hospital in Padang for bone scintigraphy examination. Both patients had thyroid surgery and histopathology results were adenomas. However, after the removal surgery, the patients did not have proper follow-ups. Both patients developed pelvic pain. Bone scintigraphy showed an increase of radiopharmaceutical uptake at pelvic bones and computerized tomography (CT Scan) result showed destruction at the pelvic bone areas. Conclusions: These cases highlight the necessity for adenoma thyroid patients with a risk factor for thyroid cancer to have a complete follow-up program and sufficient length period.

Uptake and effect of radioiodine exposure on SKBR-3 cell lines Miftah Irramah; Yulia Kurniawati; VY Susilo; S Setiyowati; Aisyah Elliyanti
Majalah Kedokteran Andalas Vol 43, No 1 (2020): Published in January 2020
Publisher : Faculty of Medicine, Universitas Andalas

Radioiodine has been known as an adjuvant therapy for thyroid cancer. Beside for thyroid cell, radioiodine is reported to be taken up by breast cell. It may be proposed as an alternative for breast cancer therapy. Objective: The study aim was to analyze an uptake of radioiodine and cell proliferation rate of breast cancer cell after the exposure of radioiodine. Methods: This study used SKBR-3 cell line as representative of Human Epidermal Growth Factor Receptor (HER2+) subtype. The cells were planted in DMEM medium added 10% fetal bovine serum (FBS), panstrep 1% and amphotericin B. The cells were grown until 80% confluent and then stripped. Subsequently the cells were sub-cultured on plates 12 and 6 wells respectively for measured uptake of radioiodine and cell proliferation rate after the exposure. Radioiodine uptake was calculated by sum efflux of 125 Iodine (125I) and the amount of uptake after the addition of 95% ethanol. Cell proliferation rate was measured by calculated by using clonogenic assay after iodine-131 (131I) exposure. Results: The average of iodine uptake was 194±50 cpm/106 cell. The average cell proliferation after radioiodine exposure was 54%±5%; Conclusions: Radioiodine is taken by SKBR-3 cells and it reduced cell proliferation rate. This finding shows an opportunity for radioiodine as an alternative therapy for breast cancer. Another studies are needed to understand of cell death the mechanism.

CORRELATION OF RENOGRAM WITH CYSTATIN-C LEVELS AND CREATININE CLEARANCE IN MEASURING GLOMERULAR FILTRATION RATE Aisyah Elliyanti; Iskandar Iskandar; Syaiful Azmi
Majalah Kedokteran Andalas Vol 38, No 1 (2015): Published in May 2015
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakRenogram 99mTc-DTPA (diethylenetriamine pentacetic acid) memiliki beberapa kelebihan dalam mengukur laju filtrasi glomerulus (LFG). Cystatin-c digunakan sebagai petanda biologik baru untuk memperkirakan LFG. Tujuan penelitian ini adalah untuk menentukan korelasi nilai LFG antara renogram dengan cystatin-c dan kliren kreatinin pada pasien dengan penyakit ginjal kronis (PGK). Subjek penelitian adalah pasien PGK stadium dua berdasarkan hasil estimasi LFG dengan rumus Cockroft-Gault. Pasien yang memenuhi kriteria diperiksa renogram, kadar kreatinin serum, cystatin-c dan klirens kreatinin.Rerata LFG dari 30 orang subjek yang diperiksa dengan renogram, cystatin-c, creatinine clearance, Cockroft-Gault’s formula berturut turut adalah 64.96 ml/min/1.73m2 (SD 28.047), 53.37 ml/min/1.73m2 (SD 21.29), 58.09 ml/min/1.73m2 (SD 35.45), 46.00 ml/min/1.73m2 (SD 12.06). Korelasi antara renogram dengan cystatin-c dengan nilai r = 0.585 dan p = 0.0007, antara renogram dengan klirens kreatinin dengan nilai r = 0.388 dan p = 0.03) dan antara renogram dengan rumus Cockroft-Gault’s dengan nilai r = -0.029 dan p=0.87. Pada penelitian ini didapatkan hasil korelasi yang lebih baik antara renogram dengan cystatin-c dari pada antara renogram dengan klirens kreatinin dan antara renogram dengan rumus Cockroft-Gault’s. Lebih lanjut, cystain-c merupakan alternatif yang lebih baik untuk memperkirakan LFG jika metode pemeriksaan LFG yang mendekati teknik pemeriksaan yang ideal tidak tersedia.AbstractRenogram using 99mTc-DTPA (diethylenetriamine pentacetic acid) has advantages in the measurement of glomerular filtration rate (GFR). Serum cystatin-c was recently projected to be the new marker of estimated GFR. The aim of this study is to establish correlation between GFRs, derived from renogram with cystatin-c levels and creatinine clearances in chronic kidney disease patients.We put to study thirty consecutive stage two of chronic kidney disease patients assigned based on GFR estimation by Cockroft-Gault’s formula, taking into account the serum creatinine. Cystatin-c and creatinine clearance were performed to determine of GFR and renogram was included in this study. A total of thirty subjects, the mean of GFRs were taken from renogram, cystatin-c, creatinine clearance, Cockroft-Gault’s formula were 64.96 ml/min/1.73m2 (SD 28.047), 53.37 ml/min/1.73m2 (SD 21.29), 58.09 ml/min/1.73m2 (SD 35.45), 46.00 ml/min/1.73m2 (SD 12.06) respectively. A correlation between renogram with cystatin-c (r = 0.585 and p = 0.0007) and renogram with creatinine clearance (r = 0.388 and p = 0.03) and renogram with Cockroft-Gault’s formula (r = -0.029 and p=0.87). This study has shown that a better correlation between renogram with cystatin-c than with creatinine clearance or Cockroft-Gault’s formula. Furthermore, cystain-c would be better alternative method incase having problems to obtain a closest ideal methods for GFR.

Karakteristik Klinikopatologi Karsinoma Payudara Invasif di RSUP Dr. M. Djamil Padang Periode 2018-2019 Sorayya A'dilah Putri; Aswiyanti Asri; Aisyah Elliyanti; Daan Khambri
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 1 (2022): Maret 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i1.664

Latar Belakang: Kanker payudara menempati urutan kedua di dunia dan menjadi penyebab kematian dari seluruh kasus kanker. Diagnosis berdasarkan karakteristik klinikopatologi karsinoma payudara invasif penting dalam menentukan tatalaksana dan prognosis kanker payudara. Objektif: Penelitian ini bertujuan untuk mengetahui gambaran karakteristik klinikopatologi karsinoma payudara invasif di RSUP Dr. M. Djamil Padang periode 2018-2019. Metode: Penelitian ini adalah penelitian deskriptif retrospektif dengan desain cross-sectional. Penelitian dilaksanakan pada Juni – Juli 2021. Sampel penelitian sebanyak 151 pasien. Data pasien didapatkan dari rekam medis, bagian bedah onkologi, dan bagian Patologi Anatomi di RSUP Dr. M. Djamil Padang. Hasil: Penderita karsinoma payudara invasif terbanyak pada usia >50 tahun (47%), Indeks Massa Tubuh (IMT) terbanyak adalah normal (47,7%). Subtipe histopatologi terbanyak adalah infiltrating duct carcinoma not otherwise specified (NOS) (75,5%) dengan stadium klinis IV (42,2%), tingkat grading pada grade II (71,5%), dan lokasi tumor pada kuadran lateral atas (30,8%). Karakteristik hormonal usia menarche ≥12 tahun (67,5%), usia menopause ≥40 tahun (34,4,%), multipara (61,6%), riwayat Hormonal Replacement Therapy (HRT) (1,3%), riwayat kontrasepsi suntik (19,9%). Karakterisitik non-hormonal didapatkan riwayat penyakit keluarga (16,6%), merokok (41,7%), tidak ada yang mengonsumsi alkohol, diet tinggi lemak (35,1%), dan riwayat radiasi (8,6%). Kesimpulan: Karakteristik klinikopatologi karsinoma payudara invasif paling banyak ditemukan pada usia lebih dari 50 tahun, IMT normal, subtipe infiltrating duct carcinoma NOS, stadium IV, grade II, lokasi tumor di kuadran lateral atas, usia menarche ≥12 tahun, usia menopause ≥40 tahun, multipara, dan riwayat kontrasepsi suntik.

MITIGASI DAN EVAKUASI BENCANA PADA MASA PANDEMI COVID-19 BAGI MASYARAKAT PASIE NAN TIGO KOTO TANGAH KOTA PADANG Aisyah Elliyanti; Julizar Julizar; Lili Irawati; Miftah Irrahmah; Afriwardi Afriwardi; Yose Ramda Ilhami; Fika Anggraini; Rahmad Syawqi
BULETIN ILMIAH NAGARI MEMBANGUN Vol 5 No 4 (2022)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v5i4.333

Disaster events both natural and non-natural factors such as epidemics can occur anytime and anywhere, which can affect communities and individuals. This natural or human-caused event or series of events can result in human casualties and suffering. Losses caused by disasters can be minimized or prevented if people's understanding of the disaster itself is sufficient, especially during the Covid-19 pandemic. Purpose: This activity is to conduct disaster mitigation training in the conditions of the Covid-19 pandemic for teachers at the Kanzul Ulum Islamic Boarding School, Kelurahan, in Pasie Nan Tigo, Koto Tangah District, Padang City. Activity target: the people of Pasie Nan Tigi Koto are able to carry out disaster mitigation and evacuation in the event of an earthquake followed by a tsunami, rising sea levels and waves. Method: activities in the form of lectures and exercises that begin with the distribution of masks to all participants involved in the activity, and filling out questionnaires on Covid-19 prevention and disaster management. After delivering the material, it was followed by a discussion on Covid-19 prevention, as well as drills on disaster mitigation and victim evacuation. The results of the activity were an increase in disaster mitigation and evacuation capabilities as well as an increase in participants' awareness in implementing health protocols for the prevention of Covid-19. Most of the participants' understanding of Covid-19 prevention and disaster management had increased, as evidenced by the increase in the number of correct questionnaire answers during the post-test compared to the pre-test from 50% to 80%. In addition, participants' skills have also increased regarding disaster mitigation, the implementation of evacuation techniques when a disaster occurs and how to evacuate victims when the disaster has subsided. Conclusion: Every individual left behind in a disaster-prone area needs to receive knowledge and training skills in disaster mitigation and evacuation techniques during the Covid-19 pandemic.

Hubungan Nilai Treshold dengan KadarAngiotensin Converting Enzyme-2 Sabar Hutabarat; Eti Yerizel; Aisyah Elliyanti; Yulia Iriani
Majalah Kedokteran Andalas Vol 46, No 2 (2023): Online April 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i2.p424-428.2023

Introduction: The coronavirus disease-19 (COVID-19) pandemic has been a major problem in every country worldwide. Cases of COVID-19 in children are usually caused by exposure to infected family members or other adults infected with the disease. Clinical manifestations in children vary widely from symptomatic to asymptomatic. This study aims to determine the relationship between cycle threshold (Ct) value with Angiotensin Converting Enzyme-2 (ACE-2) Method: This study is an observational study with a cross-sectional design. The purpose is to analyze the relationship between Ct value with ACE-2, IL-6, IL-10 level in asymptomatic COVID-19 pediatric patients. Ct value measured using RT-PCR and ACE 2, Il-6 and IL-10 were measured using ELISA examinations. Result: Mean of ACE-2 is 132,66 ± 38,19 pg/mL (21,63 – 171,63 pg/m). Conclusion: The majority of Ct value in asymptomatic pediatric COVID-19 patients were high (85,7%). Statistically, there was no significant correlation between Ct value with ACE-2, IL-6 and IL-10 in COVID-19 asymptomatic children. Keyword: Angiotensin Converting Enzyme-2, Covid-19 Asymptomatic Children

Hubungan HBD-3 Pada Selaput Amnion Ketuban Pecah Dini dengan Persalinan Normal Meidrin Joni; Eryati Darwin; Herlambang Herlambang; Aisyah Elliyanti Elliyanti
Majalah Kedokteran Andalas Vol 46, No 5 (2023): Supplementary July 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i5.p801-804.2023

Tujuan: untuk melihat perbedaan kadar protein HBD-3 antara kejadian KPD dengan persalinan normal. Metode: Penelitian ini merupakan penelitian observasional dengan desain case-control untuk menilai rasio HBD-3 pada selaput amnion pada KPD dan persalinan normal. Hasil: Hasil penelitian ini menunjukkan bahwa konsentrasi HBD-3 pada grup KPD (3,10 ng/mL) yang tidak berbeda signifikan (P=0,537) dibandingkan grup kelahiran normal (3,10 ng/mL). Kesimpulan: Tidak terdapat perbedaan kadar protein HBD-3 antara kejadian KPD dan persalinan normal.

Treatment Problems In Triple Negative Breast Cancer Thira Fasril; Noza Hilbertina; Aisyah Elliyanti
Jurnal Medis Islam Internasional Vol 4 No 2 (2023): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v4i2.3951

Background: Breast cancer ranks second on the list of common diseases worldwide. It causes many deaths in the United States and Europe, second only to lung cancer. Triple-negative breast cancer (TNBC) does not express Estrogen Receptor (ER), Progesterone Receptor (PR), and Human Epithelial Receptor (HER2). It represents 24% of new cases of all breast cancer, and its incidence increases yearly. TNBC is a hormone-resistant breast cancer, so no current standard therapy exists. This article aims to explore regimen-resistant and troubleshooting treatment responses in TNBC cases. The method of writing this article is a literature review of studies using the keywords triple-negative breast cancer treatment and regimen, which are limited to only the most recent articles, 2012-2022, using search engines from PubMed, Science Direct, and Google Scholar. Results: There is no definitive therapy for the triple-negative breast cancer subtype, in which the TNBC type has no target receptor. Chemotherapy is the SOC of TNBC for early stage treatment. For late-stage and relapsed TNBC, however, chemotherapy is no longer the first choice. Currently there is no standard chemotherapy regimen that can be given to patients who experience relapse after chemotherapy because they will have a short response and lead to metastases. Some studies have shown that chemotherapy gives a better response, but the prognosis of TNBC remains poor. TNBC has different responses to therapy. TNBC showed a good response to combination chemotherapy along with pembrolizumab, capecitabine, olaparib, and radiotherapy, compared to chemotherapy by itself. Surgical therapy, such as Breast-Conserving Surgery (BCS), does not improve better prognosis in TNBC patients. Conclusions: Combining pembrolizumab, olaparib, capecitabine, and radiotherapy with chemotherapy increased survival rates compared to chemotherapy only.

Bacterial Profile and Antimicrobial Resistance Patterns of Pleural Empyema in Pekanbaru Hospitals Indra Yovi; Dodi Safari; Nur Afrainin Syah; Dewi Anggraini; Zulfa Nur Hanifah; Vanesya Zahrani Shapira; Aisyah Elliyanti
Jurnal Respirologi Indonesia Vol 44, No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.590

Background: Empyema is a problem worldwide due to its high incidence, mortality, and morbidity rates. So, administering antibiotics is mandatory to treat the disease. It should be sensitive to the causal microorganisms and avoid resistant ones for treatment efficacy. This research aimed to determine bacterial profile and antimicrobial resistance, which can be fundamental foundations for clinical practices in the treatment of patients, especially in Pekanbaru.Methods: This was a cross-sectional study from medical records at Arifin Achmad and Eka Hospitals from January 1, 2015, to December 31, 2022, including culture and antibiotic resistance test results with samples from pleural fluid and antibiotic susceptibility test using VITEK 2.0.Results: A total of 197 pleural fluid specimens were obtained. Gram-negative bacteria were found to be the most prevalent at 79.7%, namely Klebsiella pneumoniae (18.5%), Escherichia coli (12.0%), and Pseudomonas aeruginosa (11.0%). Gram-positive bacteria were found at 12.2%, the most common being Staphylococcus aureus (6.1%) and Enterococcus faecalis (2.0%). Antibiotic sensitivity tests for Gram-negative bacteria showed that amikacin and tigecycline were the most sensitive, and Gram-positive bacteria showed the most sensitivity to linezolid, tigecycline, and vancomycin. The resistance of Klebsiella pneumoniae and Escherichia coli to cephalosporins was 18.5% and 75.0%, respectively. The resistance of Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa to carbapenems was 8.0%, 13.0%, and 53.0%, respectively.Conclusion: Gram-negative is the most common microorganism found in pleural empyema. The resistance of multiresistant bacteria to antibiotics is high and requires supervision to apply appropriate antibiotic administration based on local antimicrobial patterns and the need to strengthen antimicrobial stewardship programs.

Pengaruh pemberian Iodine-131 terhadap viabilitas cell line Triple Negative Breast Cancer (TNBC) Katrin Monika; Aisyah Elliyanti; Yulia Kurniawati
Majalah Kedokteran Andalas Vol 46, No 6 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p912-918.2023

AbstractObjective: To determine the effect of Iodine-131 administration on the viability of triple negative breast cancer cell lines and the IC50 value of Iodine-131. Methods: This study was a true experimental study using the MTT assay method to measure cell line viability after being given Iodine-131 at a dose of 7.8; 15.6; 31.3; 62.5; 125; 250; and 500 µCi for 24 hours. The research sample was the MDA-MB231 cell line which represents the Triple Negative Breast Cancer (TNBC) subtype of breast cancer. The IC50 value of Iodine-131 cell line MDA-MB231 was calculated using the GraphPad Prism-9 software. The results were analyzed using the Kruskal-Wallis and Post-Hoc Kruskal-Wallis tests, if p <0.05 was considered to significantly affect cell viability. Results: Iodine-131 affected cell viability in the MDA-MB231 cell line with a p<0.05. The IC50 value of Iodine-131 on the MDA-MB231 cell line was 255.7 µCi. Conclusion: Administration of Iodine-131 at a dose of 500 µCi for 24 hours significantly reduced the viability of the MDA-MB231 cell line. Iodine-131 dose of 255.7 µCi can inhibit 50% viability of the MDA-MB231 cell line.Keywords: Iodine-131; cell viability; cell line MDA-MB231; TNBC; IC50

Co-Authors Afriwardi Afriwardi Andani Eka Putra Arina Widya Murni Arnelis Arnelis Arni Amir Ashal, Taufik Aswiyanti Asri Daan Khambri Dewi Anggraini Dian Pertiwi Dian Pertiwi Dodi Safari Elizabeth Bahar Elmatris Sy Eryati Darwin Eti Yerizel Eti Yerizel Faiz Chalidzar Fika Anggraini Fitri Wahyu Febriwani Hendriati, Hendriati Herlambang Herlambang Husnil Wardiyah Ika Kurnia Febrianti Ilmiati Ilmiati Indra Yovi Iskandar Iskandar Johan S. Masjhur, Johan S. Julizar Julizar Julizar Julizar Katrin Monika Lili Irawati Meidrin Joni Miftah Irrahmah Miftah Irramah Mohamad Reza Noormartany . Nora Harminarti Noza Hilbertina Nur Afrainin Syah Nurhajjah, Sitti Rahmad Syawqi Rahmat Syawqi RAVEINAL RAVEINAL Rina Gustia S Setiyowati Sabar Hutabarat Siti Nurhajjah Sorayya A'dilah Putri Suminta RS, Teresia Syaiful Azmi Tenny Putri Wikayani, Tenny Putri Thira Fasril Tri Hanggono Achmad Vanesya Zahrani Shapira VY Susilo Yose Ramda Ilhami Yose Ramda Ilhsmi Yulia Iriani, Yulia Yulia Kurniawati Yulia Kurniawati Yulistini, Yulistini Zelly Dia Rofinda Zelly Dia Rofinda Zulfa Nur Hanifah

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