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All Journal Majalah Kedokteran Bandung Jurnal Kesehatan Andalas Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Buletin Ilmiah Nagari Membangun Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Science Midwifery Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Ilmu Kesehatan Indonesia (JIKSI) Andalas Dental Journal Asian Journal of Healthcare Analytics Indonesian Journal of Advanced Research (IJAR) Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI)
Ilmiawati, Ilmiawati
Universitas Andalas
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Journal : Majalah Kedokteran Bandung

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Gestational Monosodium Glutamate Exposure Effects on Anogenital Distance of Male Rat Pups Amelya Permata Sari; Cimi Ilmiawati; Mohamad Reza
Majalah Kedokteran Bandung Vol 53, No 2 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n2.2302

Abstract

High-dose Monosodium Glutamate (MSG) expo sure increases the estrogen level in pregnant rats. However, there are limited data available on whether the MSG-related maternal hormonal effects can affect male litters' genitalia phenotype. This study aimed to analyze the impact of MSG on estrogen level in pregnant rats and anogenital distance in male pups. Experiment for this study was performed at the animal facility of Biomedical Laboratory at the Faculty of Medicine, Universitas Andalas, from April 2019 to February 2020. Pregnant Wistar rats were given MSG orally at 2 and 4 mg/g body weight (BW) for 20 days. On day 21, pregnant rats were sacrificed and blood was drawn intracardially. Estradiol serum level was measured by ELISA. Male pups were counted, and the anogenital distance (AGD) was measured. Maternal serum estradiol levels were statistically analyzed by One-Way ANOVA and the AGD of male litters were analyzed by the Kruskal-Wallis test. Results showed that perinatal MSG exposure increased the estradiol level (26.3±4.5 pg/ml; 37.5±6.7 pg/ml; 62.1±8.2 pg/ml in control, 2 mg/g BW, and 4 mg/g BW group, respectively [mean±SD; p=<0.001]) and decreased the AGD (4 mm; 3 mm; 1.5 mm in control, 2 mg/g BW, and 4 mg/gBW group, respectively [median; p=<0.01]) in a dose-dependent manner. Thus, MSG exposure during pregnancy is a risk factor for male rat feminization. 
Co-Authors Ade Asyari Adrial Adrial Afriwardi Afriwardi Al Hafiz Amel Yanis Amelya Permata Sari Amir, Arni Andi Friadi Asa Mutra Ma’isya Athica Oviana Aurelia Agantha Salim Aziz Djamal bambang bambang Delfina Delfina Desmawati Desmawati Dessy Arisanty Dita Viviant Sagith Dwitya Elvira Efrida Efrida Eka Fithra Elfi Eka Nofita Elizabeth Bahar Elliza Nasrul Elly Usman Elmatris Elmatris Elmatris Sy Elwitri Silvia Emilzon Taslim Eni Rahmi Erlina Rustam Fachzi Fitri Farina Angelia Firdawati Firdawati Geo Ghazali Gusman Gestina Aliska Gustia Anugrahwati Haidar Haikal Fasya Hasmiwati Havina Nurul Aizah Hendriati, Hendriati Hirowati Ali Ihsan Otriami Intan Nurwida Hayati Yasrial Julizar Julizar Kiran Nandini Kiran Nandini Laila Isrona Lastri Daniati Lihayati Lihayati Lili Irawati Mahata, Liganda Endo Mefri Yanni Mhd. Al Zaref Mhicya Utami R Mohamad Reza Mohamad Reza Muhammad Ihsan Fadillah Muhammad Rayhandi Naufal Multazam Fahreza Chandra Nadiah Mardhatillah Defani Netti Suharti Nice Rachmawati Masnadi Nova Suryati Nur Afrainin Syah Nur Indrawaty Lipoeto Nurhayati Nurhayati Nuzulia Irawati Pretty Shinta Amalia Rahmat Dwi Putra Perkasa Rahmatini . Rahmi Lestari Rahmi Novira Putri Rani Aulia Dwi Nanda Rani Aulia Dwi Nanda Rawzan Abdul Aziz Rima Semiarty Russilawati, Russilawati Selfi Renita Rusjdi Septriana Putri Siti Nurhajjah Siti Syiehan Muhdalin Suci Rahmawati Annabawi Suhanda Saputra Sukri Rahman Syamel Muhammad Syihabuddin Hasan Kholili Tofrizal Tofrizal Vaulline Basyir Vaulline Basyir Violita Dianatha Puteri Yanti, Roza Sri Yulistini, Yulistini Yuniar Lestari Yusticia Katar