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Journal : The Indonesian Biomedical Journal

Association of rs10830963 MTNR1B and rs841853 SLC2A1 Polymorphism with Obesity on Type 2 Diabetes Patients: An Overview of Melatonin Receptor and Transporter Yanuarita Tursinawati; Arum Kartikadewi; Ari Yuniastuti; R Susanti
The Indonesian Biomedical Journal Vol 13, No 2 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i2.1488

Abstract

BACKGROUND: One of the hormones that plays a role in glucose metabolism of Type 2 Diabetes Mellitus (T2DM) is melatonin. Its genetic variation is believed to play a significant role in the pathophysiology of obese and non-obese T2DM. The role of MTNR1B (melatonin receptor coding gene) and SLC2A1 (Glucose transporter 1/GLUT 1 transporter coding gene) on the risk of obese and non-obese T2DM patients is controversial. This study aims to analyze the association between the rs10830963 MTNR1B and rs841853 SLC2A1 polymorphism to the risk of Javanese obese T2DM.METHODS: This was a cross-sectional study that involved 107 Javanese T2DM patients from primary heath care in Semarang. Furthermore, obese T2DM was defined by a body mass index (BMI) more than 25 kg/m2. The genetic variations examined were rs10830963 MTNR1B and rs841853 SLC2A1 polymorphism by PCR-RFLP methods. Blood biochemistry parameters were also examined. Allele and genotype frequencies of rs10830963 MTNR1B and rs841853 SLC2A1 polymorphisms were analyzed using the x2 test with p≤0.05 and 95% CI.RESULTS: There was a significant association between rs10830963 MTNR1B polymorphisms in obese and nonobese T2DM (p=0.044) and the CG genotype increased the risk of obese T2DM. Furthermore, the allele and genotype frequency of rs841853 SLC2A1 polymorphism in both group had no significant difference, with a p=0.756 and p=0.802, respectively. There was also no significant difference in the biochemical parameters' in both groups of the two genetic variants studied.CONCLUSION: The rs10830963 MTNR1B polymorphism is associated with the risk of obesity in Javanese T2DM patients but not for the rs841853 SLC2A1 polymorphism.KEYWORDS: polymorphism, MTNR1B, SLC2A1, obese, diabetes mellitus
Co-Authors Abdurrahman Ali, Nur Aini Abudu, Komaria Ode AD Safarina Adevia Maulidya Chikmah, Adevia Maulidya Adhisti Lutfia Hanan Adhisti Lutfia Hanan Adiba, Daniar Arof Adiba, Daniar Arof Aennie Widiastuti, Vinka Afniyati, Nur Afniyati, Nur Agnes Dwi Safarina Agnes Dwi Safarina Aidah, Nur Aisa Nikmah Rahmatih Amalia, Devi Andreas Priyono Budi Prasetyo Arif Kurniadi Ariyanto, Andhika Arum Kartikadewi Arum Kartikadewi Arum Kartikadewi Asih Kuswardinah Asyumdah, Asyumdah Budi Laksono Budi, Dini Wurnaning Budu - Candrawan, Roni Prasetyo Darmayanti, Mey Linda Devi Dwi Jayanti Dewi Mustikaningtyas Dina Nur Anggraini Ningrum Dinda Fuji Islamiyanti Dyah Rini Indriyanti Eko Farida Elissa, Intan Ayu Ell Khaq, Arrina Ely Rudyatmi, Ely Eunike Raffy Rustiana Evi Widowati F. Putut Martin HB Farida, Eko Fathnin, Fildza Huwaina Feri Dwi Agustina Feri Dwi Agustina Fidia Fibriana Fitri Arum Sasi Fitri Arum Sasi, Fitri Arum Halimah, Khori Handayani, Kasmini Hidayah, Arifatul Hidayah, Salis Nur I Wayan Suardana Ibnul Mubarok Ibnul Mubarok Indah Hartati Innayah, Nurul Irawan Yusuf Irawan Yusuf Irwan Irwan Isnaeni, Lili Astuti Isnaeni, Lili Astuti Isti Mulyawati Istianah Istianah Istiqomah Dwi Andari, Istiqomah Dwi Istiqomah, Annisa Aulia Jiwanjaya, Yoga Juwita, Fitra Kamala Nuriyah Kamilatussainah Kamilatussainah Kamisih, Kamisih Karomika, Ati Kasimi, Oktia Woro Khikmatul Maula, Lia Kirana Rannoe Tirta Kirana Rannoe Tirta Krispinus Kedati Pukan lathifah, Ummu Lindasari, Pamela Lisdiana Lisdiana Lucita, Fifty K. Lyndasari, Pamela Mahalul Azam Martien Herna Susanti Mayang Siwi Dewayanti, Mayang Siwi Merzistya, Aufiena Nur Ayu Mohamad Endy Y Yulianto Muchamad Dafip Muchamad Dafip Muh Nasrum Massi Muh. Nasrum Massi Nabila Azzahra Luthfiah Nabila Azzahra Luthfiah Nadhifah, Shiliya Lana Nadhifah, Shiliya Lana Nbaia, Sara M Mohamed Negarani, Eryca Nur Bela Negarani, Eryca Nur Bela Niken Subekti Ning Setiati Ning Setiati Nirmala Al Fatiah Nirmala Al Fatiah Noor Aini Habibah Noor Hidayah Nugrahanigsih WH Nugrahaningsih Nugrahaningsih Nugrahaningsih Nugrahaningsih Nugrahaningsih Nugrahaningsih Nugrahaningsih W H Nugrahaningsih W H Nugrahaningsih WH Nugrahaningsih WH Nugrahaningsih WH, Nugrahaningsih Nur Kusuma Dewi Nur Rahayu Utami NURUL HIDAYAH Oktia Woro Oktia Woro Kasmini H Oktia Woro Kasmini Handayani Pramesti Dewi Pramusinta, Linda Prasetyowati, Tri Ari Priyantini Widiyaningrum R Susanti R Susanti R Susanti R Susanti R Susanti R Susanti R Susanti R Susanti R. Susanti Rahayu, Rr. Sri Ratna Rahmatih, Aisa Nikmah Rahmatika Saputri R Ratna Rahayu, Sri Ratna Rahayu, Sri Resti Fitriati Retno Sri Iswari Retno Sri Iswari Rofika, Ana Rohmah, Amalia Nor Rr. Sri Ratna Rahayu Sa’adah, Siti Rofiatus Saiful Ridlo Satriani Satriani Sekar Arum, Vriska Roro Setyoko Setyoko Sholikah, Anik Sholikah Shovrotul Khoiriyah, Ely Siti Alimah Siti Alimah Siti Baitul Mukarromah Siti Isnaeni SITI MAHMUDAH Sri Mulyani Endang Susilowati, Sri Mulyani Endang Sri Ratna Rahayu, Rr Sugianto Sulasfiana Alfi Raida, Sulasfiana Alfi Sulistiani, Duwi Sulistyawati, Anita Syarifah, Aidah Nur Talitha Widiatningrum Totok Sumaryanto Florentinus, Totok Sumaryanto Tyas Agung Pribadi Umam, Syaiful Ishlahul Utami, Hanna Dewi Utami, Hanna Dewi Vilda Ana Veria Setyawati Vilda Ana Veria Setyawati Virtanti, Uji Wahyuningtyas, Arini Tri Widya Hary Cahyati Wiwi Isnaeni Woro K H, Oktia Yanti, Erny Yuni Yanuarita Tursinawati Yanuarita Tursinawati Yanuarita Tursinawati Yanuarita Tursinawati Yuni Wijayanti yuniarti, christina ary Yusdike Adystia Zunikhah Zunikhah Zunikhah Zunikhah